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小动物多模成像系统中的软硬件模块开发与图像去噪方法研究
其他题名Research on Software and Hardware Modules Development of Multimodality Imaging System for Small Animals and Image Denoising
施亮亮
学位类型工学硕士
导师戴汝为
2015-05-25
学位授予单位中国科学院大学
学位授予地点中国科学院自动化研究所
学位专业模式识别与智能系统
关键词医学影像 多模态成像 软硬件开发 图像去噪 Medical Imaging Multimodality Imaging Hardware And Software Development Image Denoising
摘要生物医学基础研究的应用需求拉动了医学影像的快速发展:从成像模态上看,单模态成像越来越向多模态融合成像发展;从成像对象的尺度上看,最初由宏观尺度的成像转向微观尺度的成像和连接微观和宏观的介观成像。由于单一模态的成像系统不能提供生物体全面的生理病理信息,融合不同成像模态的多模态成像系统是一项具有重大现实意义的重大课题。同时,为了加快生物医学基础研究,需要对不同成像尺度的生物样本进行三维成像。光学投影断层成像是一种介于宏观尺度和微观尺度的高分辨率介观尺度成像技术,但其影像质量受到系统噪声的影响,亟需深入展开对噪声的去除研究。 本文针对小动物多模成像系统的软硬件模块开发和图像去噪方法展开研究,涵盖了硬件、软件系统的设计和实现以及光学图像去噪算法,实现了多模态影像数据的单机采集并提高了光学投影断层成像的图像质量。本文的主要研究内容包括以下几点: 1、设计了基于滑环的转盘式小动物多模成像系统的机械结构,划分了整个硬件系统的硬件组成,详细介绍了系统的关键器件。机械结构分为支架台、旋转电机及多模态旋转平台、水平可移动鼠床等三部分。硬件系统组成划分为:激发源/射线源系统、探测系统、数据采集系统、机械旋转和水平移动系统、控制系统、计算机系统以及图像存储于显示设备等。 2、设计了小动物多模成像系统控制软件的架构并实现了具体功能。通过分层设计的方式将系统控制软件分为抽象层和应用层,抽象层对系统特定硬件控制接口进行了封装,应用层根据抽象层的统一接口实现软件的功能设计。分层设计降低了系统软硬件的耦合度和复杂度。根据系统成像任务设计了软件的主界面,设计并实现了系统具体功能,包括系统位置调整模块、CT数据采集模块以及光学数据采集模块。 3、开展了光学投影断层成像去噪方法研究。通过对光学投影断层成像技术中的固有噪声及其影响的分析,对固有噪声建立了含有先验信息的统计模型,并在此模型上进行去噪。利用经过了透明化处理的小鼠心脏实验验证了本文方法的有效性。
其他摘要The applications of biomedical fundamental research have been driving the rapid development of medical imaging. From the point of imaging modality, the medical imaging analysis gradually turns from a single modality imaging to multimodality imaging. From the point of imaging scale, the medical imaging turns from the traditional macro-scale imaging to microscopic and mesoscopic imaging. Because the single modality imaging system cannot provide comprehensive physiological and pathological information for the organisms, the multimodality imaging system is a major issue of great practical significance. Meanwhile, in order to accelerate the biomedical fundamental research, it’s necessary to get the three-dimensional imaging for biological samples of different scales. Optical projection tomography is a high resolution and mesoscopic imaging technology, which is cross between the macro-scale and micro-scale. However, its image quality is highly affected by the system’s noise and it is urgent to develop effective denoising algorithm. This thesis mainly does research on the software and hardware modules development of multimodality imaging system for small animals and image denoising, which implements a multimodality imaging system for small animals and improves the image quality of optical projection tomography. The main contributions of this thesis are listed as follows: (1) We have designed the mechanical structure of the multimodality imaging system, divided the system’s composition of hardware and described the details of the system’s key components. The mechanical structure is divided into three parts: the holder, the rotary multimodality platform and the mouse bed which can move horizontally. The hardware system is made up of an excitation source (or X-ray source) module, a detection module, a data acquisition module, a mechanical rotation an horizontal movement module, a control module, a computer and a storage and display device. (2) We have designed the imaging system’s software architecture and implementation the software. The software is divided into abstraction layer and application layer. The abstraction layer provides the package interface of the system’s hardware, the application layer use the abstraction layer’s interface to implement the system’s functions. This hierarchical design reduces the complexity of the system. The software’s main GUI is designed according to the system’s tasks, and the software functions mainly incl...
其他标识符201228014628051
语种中文
文献类型学位论文
条目标识符http://ir.ia.ac.cn/handle/173211/7743
专题毕业生_硕士学位论文
推荐引用方式
GB/T 7714
施亮亮. 小动物多模成像系统中的软硬件模块开发与图像去噪方法研究[D]. 中国科学院自动化研究所. 中国科学院大学,2015.
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