The applications of biomedical fundamental research have been driving the rapid development of medical imaging. From the point of imaging modality, the medical imaging analysis gradually turns from a single modality imaging to multimodality imaging. From the point of imaging scale, the medical imaging turns from the traditional macro-scale imaging to microscopic and mesoscopic imaging. Because the single modality imaging system cannot provide comprehensive physiological and pathological information for the organisms, the multimodality imaging system is a major issue of great practical significance. Meanwhile, in order to accelerate the biomedical fundamental research, it’s necessary to get the three-dimensional imaging for biological samples of different scales. Optical projection tomography is a high resolution and mesoscopic imaging technology, which is cross between the macro-scale and micro-scale. However, its image quality is highly affected by the system’s noise and it is urgent to develop effective denoising algorithm. This thesis mainly does research on the software and hardware modules development of multimodality imaging system for small animals and image denoising, which implements a multimodality imaging system for small animals and improves the image quality of optical projection tomography. The main contributions of this thesis are listed as follows: (1) We have designed the mechanical structure of the multimodality imaging system, divided the system’s composition of hardware and described the details of the system’s key components. The mechanical structure is divided into three parts: the holder, the rotary multimodality platform and the mouse bed which can move horizontally. The hardware system is made up of an excitation source (or X-ray source) module, a detection module, a data acquisition module, a mechanical rotation an horizontal movement module, a control module, a computer and a storage and display device. (2) We have designed the imaging system’s software architecture and implementation the software. The software is divided into abstraction layer and application layer. The abstraction layer provides the package interface of the system’s hardware, the application layer use the abstraction layer’s interface to implement the system’s functions. This hierarchical design reduces the complexity of the system. The software’s main GUI is designed according to the system’s tasks, and the software functions mainly incl...
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