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Intensity Enhanced Cerenkov Luminescence Imaging Using Terbium-Doped Gd2O2S Microparticles
Cao, Xin1,2; Chen, Xueli1,2; Kang, Fei3; Zhan, Yonghua1,2; Cao, Xu1,2; Wang, Jing3; Liang, Jimin1,2; Tian, Jie1,2,4
2015-06-10
发表期刊ACS APPLIED MATERIALS & INTERFACES
卷号7期号:22页码:11775-11782
文章类型Article
摘要Weak intensity and poor penetration depth are two big obstacles toward clinical use of Cerenkov luminescence imaging (CLI). In this proof-of-concept study, we overcame these limitations by using lanthanides-based radioluminescent microparticles (RLMPs), called terbium doped Gd2O2S. The characterization experiment showed that the emission excited by Cerenkov luminescence can be neglected whereas the spectrum experiment demonstrated that the RLMPs can actually be excited by gamma-rays. A series of in vitro experiments demonstrated that RLMPs significantly improve the intensity and the penetration capacity of CLI, which has been extended to as deep as 15 mm. In vivo pseudotumor study further prove the huge potential of this enhancement strategy for Cerenkov luminescence imaging in living animal studies.
关键词Biophotonics Imaging Cerenkov Luminescence Radioluminescence Biomaterials
WOS标题词Science & Technology ; Technology
关键词[WOS]STATE LIGHTING APPLICATIONS ; WHITE EMISSION ; NANOPHOSPHORS ; PROBES ; TOMOGRAPHY ; CONVERSION ; RADIATION ; PET ; FEASIBILITY ; F-18-FDG
收录类别SCI
语种英语
WOS研究方向Science & Technology - Other Topics ; Materials Science
WOS类目Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号WOS:000356316700010
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/7910
专题中国科学院分子影像重点实验室
作者单位1.Xidian Univ, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710071, Shaanxi, Peoples R China
2.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
3.Fourth Mil Med Univ, Xijing Hosp, Dept Nucl Med, Xian 710032, Shaanxi, Peoples R China
4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
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Cao, Xin,Chen, Xueli,Kang, Fei,et al. Intensity Enhanced Cerenkov Luminescence Imaging Using Terbium-Doped Gd2O2S Microparticles[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(22):11775-11782.
APA Cao, Xin.,Chen, Xueli.,Kang, Fei.,Zhan, Yonghua.,Cao, Xu.,...&Tian, Jie.(2015).Intensity Enhanced Cerenkov Luminescence Imaging Using Terbium-Doped Gd2O2S Microparticles.ACS APPLIED MATERIALS & INTERFACES,7(22),11775-11782.
MLA Cao, Xin,et al."Intensity Enhanced Cerenkov Luminescence Imaging Using Terbium-Doped Gd2O2S Microparticles".ACS APPLIED MATERIALS & INTERFACES 7.22(2015):11775-11782.
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