CASIA OpenIR  > 中国科学院分子影像重点实验室
Intensity Enhanced Cerenkov Luminescence Imaging Using Terbium-Doped Gd2O2S Microparticles
Cao, Xin1,2; Chen, Xueli1,2; Kang, Fei3; Zhan, Yonghua1,2; Cao, Xu1,2; Wang, Jing3; Liang, Jimin1,2; Tian, Jie1,2,4
Source PublicationACS APPLIED MATERIALS & INTERFACES
2015-06-10
Volume7Issue:22Pages:11775-11782
SubtypeArticle
AbstractWeak intensity and poor penetration depth are two big obstacles toward clinical use of Cerenkov luminescence imaging (CLI). In this proof-of-concept study, we overcame these limitations by using lanthanides-based radioluminescent microparticles (RLMPs), called terbium doped Gd2O2S. The characterization experiment showed that the emission excited by Cerenkov luminescence can be neglected whereas the spectrum experiment demonstrated that the RLMPs can actually be excited by gamma-rays. A series of in vitro experiments demonstrated that RLMPs significantly improve the intensity and the penetration capacity of CLI, which has been extended to as deep as 15 mm. In vivo pseudotumor study further prove the huge potential of this enhancement strategy for Cerenkov luminescence imaging in living animal studies.
KeywordBiophotonics Imaging Cerenkov Luminescence Radioluminescence Biomaterials
WOS HeadingsScience & Technology ; Technology
WOS KeywordSTATE LIGHTING APPLICATIONS ; WHITE EMISSION ; NANOPHOSPHORS ; PROBES ; TOMOGRAPHY ; CONVERSION ; RADIATION ; PET ; FEASIBILITY ; F-18-FDG
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000356316700010
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/7910
Collection中国科学院分子影像重点实验室
Affiliation1.Xidian Univ, Minist Educ, Engn Res Ctr Mol & Neuro Imaging, Xian 710071, Shaanxi, Peoples R China
2.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
3.Fourth Mil Med Univ, Xijing Hosp, Dept Nucl Med, Xian 710032, Shaanxi, Peoples R China
4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Cao, Xin,Chen, Xueli,Kang, Fei,et al. Intensity Enhanced Cerenkov Luminescence Imaging Using Terbium-Doped Gd2O2S Microparticles[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(22):11775-11782.
APA Cao, Xin.,Chen, Xueli.,Kang, Fei.,Zhan, Yonghua.,Cao, Xu.,...&Tian, Jie.(2015).Intensity Enhanced Cerenkov Luminescence Imaging Using Terbium-Doped Gd2O2S Microparticles.ACS APPLIED MATERIALS & INTERFACES,7(22),11775-11782.
MLA Cao, Xin,et al."Intensity Enhanced Cerenkov Luminescence Imaging Using Terbium-Doped Gd2O2S Microparticles".ACS APPLIED MATERIALS & INTERFACES 7.22(2015):11775-11782.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Cao, Xin]'s Articles
[Chen, Xueli]'s Articles
[Kang, Fei]'s Articles
Baidu academic
Similar articles in Baidu academic
[Cao, Xin]'s Articles
[Chen, Xueli]'s Articles
[Kang, Fei]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Cao, Xin]'s Articles
[Chen, Xueli]'s Articles
[Kang, Fei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.