In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging

	In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging
	Hu, Zhenhua1,2 ; Qu, Yawei 3; Wang, Kun1,2 ; Zhang, Xiaojun 4; Zha, Jiali 3; Song, Tianming 1; Bao, Chengpeng 1; Liu, Haixiao1 ; Wang, Zhongliang 5; Wang, Jing 6; Liu, Zhongyu 7; Liu, Haifeng 3; Tian, Jie 1,2,8
发表期刊	NATURE COMMUNICATIONS
	2015-06-01
卷号	6 期号:-页码:-
文章类型	Article
摘要	Cerenkov luminescence imaging utilizes visible photons emitted from radiopharmaceuticals to achieve in vivo optical molecular-derived signals. Since Cerenkov radiation is weak, non-optimum for tissue penetration and continuous regardless of biological interactions, it is challenging to detect this signal with a diagnostic dose. Therefore, it is challenging to achieve useful activated optical imaging for the acquisition of direct molecular information. Here we introduce a novel imaging strategy, which converts g and Cerenkov radiation from radioisotopes into fluorescence through europium oxide nanoparticles. After a series of imaging studies, we demonstrate that this approach provides strong optical signals with high signal-to-background ratios, an ideal tissue penetration spectrum and activatable imaging ability. In comparison with present imaging techniques, it detects tumour lesions with low radioactive tracer uptake or small tumour lesions more effectively. We believe it will facilitate the development of nuclear and optical molecular imaging for new, highly sensitive imaging applications.
关键词	-
WOS标题词	Science & Technology
关键词[WOS]	CERENKOV LUMINESCENCE TOMOGRAPHY ; F-18-FDG PET ; NANOPHOSPHORS ; RADIOTRACERS ; FEASIBILITY ; GENERATION ; PROBES ; MODEL
收录类别	SCI
语种	英语
WOS研究方向	Science & Technology - Other Topics
WOS类目	Multidisciplinary Sciences
WOS记录号	WOS:000357180700001
引用统计	被引频次：112[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/7911
专题	中国科学院分子影像重点实验室
通讯作者	Liu, Haifeng
作者单位	1.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 2.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Gen Hosp Chinese Peoples Armed Police Forces, Dept Gastroenterol, Beijing, Peoples R China 4.Chinese Peoples Liberat Army Gen Hosp, Dept Nucl Med, Beijing 100853, Peoples R China 5.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China 6.Fourth Mil Med Univ, Xijing Hosp, Dept Nucl Med, Xian 710032, Peoples R China 7.150 Cent Hosp PLA, Anal Colorectal Surg Inst, Luoyang 471031, Peoples R China 8.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China
第一作者单位	中国科学院自动化研究所; 中国科学院分子影像重点实验室
推荐引用方式 GB/T 7714	Hu, Zhenhua,Qu, Yawei,Wang, Kun,et al. In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging[J]. NATURE COMMUNICATIONS,2015,6(-):-.
APA	Hu, Zhenhua.,Qu, Yawei.,Wang, Kun.,Zhang, Xiaojun.,Zha, Jiali.,...&Tian, Jie.(2015).In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging.NATURE COMMUNICATIONS,6(-),-.
MLA	Hu, Zhenhua,et al."In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging".NATURE COMMUNICATIONS 6.-(2015):-.

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