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In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging
Hu, Zhenhua1,2; Qu, Yawei3; Wang, Kun1,2; Zhang, Xiaojun4; Zha, Jiali3; Song, Tianming1; Bao, Chengpeng1; Liu, Haixiao1; Wang, Zhongliang5; Wang, Jing6; Liu, Zhongyu7; Liu, Haifeng3; Tian, Jie1,2,8
2015-06-01
发表期刊NATURE COMMUNICATIONS
卷号6期号:-页码:-
文章类型Article
摘要Cerenkov luminescence imaging utilizes visible photons emitted from radiopharmaceuticals to achieve in vivo optical molecular-derived signals. Since Cerenkov radiation is weak, non-optimum for tissue penetration and continuous regardless of biological interactions, it is challenging to detect this signal with a diagnostic dose. Therefore, it is challenging to achieve useful activated optical imaging for the acquisition of direct molecular information. Here we introduce a novel imaging strategy, which converts g and Cerenkov radiation from radioisotopes into fluorescence through europium oxide nanoparticles. After a series of imaging studies, we demonstrate that this approach provides strong optical signals with high signal-to-background ratios, an ideal tissue penetration spectrum and activatable imaging ability. In comparison with present imaging techniques, it detects tumour lesions with low radioactive tracer uptake or small tumour lesions more effectively. We believe it will facilitate the development of nuclear and optical molecular imaging for new, highly sensitive imaging applications.
关键词-
WOS标题词Science & Technology
关键词[WOS]CERENKOV LUMINESCENCE TOMOGRAPHY ; F-18-FDG PET ; NANOPHOSPHORS ; RADIOTRACERS ; FEASIBILITY ; GENERATION ; PROBES ; MODEL
收录类别SCI
语种英语
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000357180700001
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/7911
专题中国科学院分子影像重点实验室
通讯作者Liu, Haifeng
作者单位1.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
2.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Gen Hosp Chinese Peoples Armed Police Forces, Dept Gastroenterol, Beijing, Peoples R China
4.Chinese Peoples Liberat Army Gen Hosp, Dept Nucl Med, Beijing 100853, Peoples R China
5.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China
6.Fourth Mil Med Univ, Xijing Hosp, Dept Nucl Med, Xian 710032, Peoples R China
7.150 Cent Hosp PLA, Anal Colorectal Surg Inst, Luoyang 471031, Peoples R China
8.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China
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GB/T 7714
Hu, Zhenhua,Qu, Yawei,Wang, Kun,et al. In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging[J]. NATURE COMMUNICATIONS,2015,6(-):-.
APA Hu, Zhenhua.,Qu, Yawei.,Wang, Kun.,Zhang, Xiaojun.,Zha, Jiali.,...&Tian, Jie.(2015).In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging.NATURE COMMUNICATIONS,6(-),-.
MLA Hu, Zhenhua,et al."In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging".NATURE COMMUNICATIONS 6.-(2015):-.
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