CASIA OpenIR  > 中国科学院分子影像重点实验室
In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging
Hu, Zhenhua1,2; Qu, Yawei3; Wang, Kun1,2; Zhang, Xiaojun4; Zha, Jiali3; Song, Tianming1; Bao, Chengpeng1; Liu, Haixiao1; Wang, Zhongliang5; Wang, Jing6; Liu, Zhongyu7; Liu, Haifeng3; Tian, Jie1,2,8
Source PublicationNATURE COMMUNICATIONS
2015-06-01
Volume6Issue:-Pages:-
SubtypeArticle
AbstractCerenkov luminescence imaging utilizes visible photons emitted from radiopharmaceuticals to achieve in vivo optical molecular-derived signals. Since Cerenkov radiation is weak, non-optimum for tissue penetration and continuous regardless of biological interactions, it is challenging to detect this signal with a diagnostic dose. Therefore, it is challenging to achieve useful activated optical imaging for the acquisition of direct molecular information. Here we introduce a novel imaging strategy, which converts g and Cerenkov radiation from radioisotopes into fluorescence through europium oxide nanoparticles. After a series of imaging studies, we demonstrate that this approach provides strong optical signals with high signal-to-background ratios, an ideal tissue penetration spectrum and activatable imaging ability. In comparison with present imaging techniques, it detects tumour lesions with low radioactive tracer uptake or small tumour lesions more effectively. We believe it will facilitate the development of nuclear and optical molecular imaging for new, highly sensitive imaging applications.
Keyword-
WOS HeadingsScience & Technology
WOS KeywordCERENKOV LUMINESCENCE TOMOGRAPHY ; F-18-FDG PET ; NANOPHOSPHORS ; RADIOTRACERS ; FEASIBILITY ; GENERATION ; PROBES ; MODEL
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000357180700001
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Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/7911
Collection中国科学院分子影像重点实验室
Corresponding AuthorLiu, Haifeng
Affiliation1.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
2.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Gen Hosp Chinese Peoples Armed Police Forces, Dept Gastroenterol, Beijing, Peoples R China
4.Chinese Peoples Liberat Army Gen Hosp, Dept Nucl Med, Beijing 100853, Peoples R China
5.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Peoples R China
6.Fourth Mil Med Univ, Xijing Hosp, Dept Nucl Med, Xian 710032, Peoples R China
7.150 Cent Hosp PLA, Anal Colorectal Surg Inst, Luoyang 471031, Peoples R China
8.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences;  Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Hu, Zhenhua,Qu, Yawei,Wang, Kun,et al. In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging[J]. NATURE COMMUNICATIONS,2015,6(-):-.
APA Hu, Zhenhua.,Qu, Yawei.,Wang, Kun.,Zhang, Xiaojun.,Zha, Jiali.,...&Tian, Jie.(2015).In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging.NATURE COMMUNICATIONS,6(-),-.
MLA Hu, Zhenhua,et al."In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging".NATURE COMMUNICATIONS 6.-(2015):-.
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