A Novel Region Reconstruction Method for Fluorescence Molecular Tomography

	A Novel Region Reconstruction Method for Fluorescence Molecular Tomography
	An, Yu 1; Liu, Jie 2; Zhang, Guanglei 1; Ye, Jinzuo3 ; Du, Yang3 ; Mao, Yamin3 ; Chi, Chongwei4 ; Tian, Jie 4
发表期刊	IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
	2015-07-01
卷号	62 期号:7 页码:1818-1826
文章类型	Article
摘要	Fluorescence molecular tomography (FMT) could exploit the distribution of fluorescent biomarkers that target tumors accurately and effectively, which enables noninvasive real-time 3-D visualization as well as quantitative analysis of small tumors in small animal studies in vivo. Due to the difficulties of reconstruction, continuous efforts are being made to find more practical and efficient approaches to accurately obtain the characteristics of fluorescent regions inside biological tissues. In this paper, we propose a region reconstruction method for FMT, which is defined as an L1-norm regularization piecewise constant level set approach. The proposed approach adopts a priori information including the sparsity of the fluorescent sources and the fluorescent contrast between the target and background. When the contrast of different fluorescent sources is low to a certain degree, our approach can simultaneously solve the detection and characterization problems for the reconstruction of FMT. To evaluate the performance of the region reconstruction method, numerical phantom experiments and in vivo bead-implanted mouse experiments were performed. The results suggested that the proposed region reconstruction method was able to reconstruct the features of the fluorescent regions accurately and effectively, and the proposed method was able to be feasibly adopted in in vivo application.
关键词	Fluorescence Molecular Tomography Piecewise Constant Level Set 3-d Reconstruction
WOS标题词	Science & Technology ; Technology
关键词[WOS]	DIFFUSE OPTICAL TOMOGRAPHY ; ELEMENT BASED TOMOGRAPHY ; RAY COMPUTED-TOMOGRAPHY ; LEVEL-SET APPROACH ; IMAGE-RECONSTRUCTION ; L1 REGULARIZATION ; IN-VIVO ; BIOLUMINESCENCE TOMOGRAPHY ; CONJUGATE-GRADIENT ; SPARSITY
收录类别	SCI
语种	英语
WOS研究方向	Engineering
WOS类目	Engineering, Biomedical
WOS记录号	WOS:000356310700015
引用统计	被引频次：51[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/7913
专题	中国科学院分子影像重点实验室
作者单位	1.Beijing Jiaotong Univ, Beijing 100044, Peoples R China 2.Beijing Jiaotong Univ, Sch Comp & Informat Technol, Dept Biomed Engn, Beijing 100044, Peoples R China 3.Chinese Acad Sci, Beijing 100864, Peoples R China 4.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	An, Yu,Liu, Jie,Zhang, Guanglei,et al. A Novel Region Reconstruction Method for Fluorescence Molecular Tomography[J]. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING,2015,62(7):1818-1826.
APA	An, Yu.,Liu, Jie.,Zhang, Guanglei.,Ye, Jinzuo.,Du, Yang.,...&Tian, Jie.(2015).A Novel Region Reconstruction Method for Fluorescence Molecular Tomography.IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING,62(7),1818-1826.
MLA	An, Yu,et al."A Novel Region Reconstruction Method for Fluorescence Molecular Tomography".IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING 62.7(2015):1818-1826.

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