CASIA OpenIR  > 中国科学院分子影像重点实验室
A Novel Region Reconstruction Method for Fluorescence Molecular Tomography
An, Yu1; Liu, Jie2; Zhang, Guanglei1; Ye, Jinzuo3; Du, Yang3; Mao, Yamin3; Chi, Chongwei4; Tian, Jie4
Source PublicationIEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
2015-07-01
Volume62Issue:7Pages:1818-1826
SubtypeArticle
AbstractFluorescence molecular tomography (FMT) could exploit the distribution of fluorescent biomarkers that target tumors accurately and effectively, which enables noninvasive real-time 3-D visualization as well as quantitative analysis of small tumors in small animal studies in vivo. Due to the difficulties of reconstruction, continuous efforts are being made to find more practical and efficient approaches to accurately obtain the characteristics of fluorescent regions inside biological tissues. In this paper, we propose a region reconstruction method for FMT, which is defined as an L1-norm regularization piecewise constant level set approach. The proposed approach adopts a priori information including the sparsity of the fluorescent sources and the fluorescent contrast between the target and background. When the contrast of different fluorescent sources is low to a certain degree, our approach can simultaneously solve the detection and characterization problems for the reconstruction of FMT. To evaluate the performance of the region reconstruction method, numerical phantom experiments and in vivo bead-implanted mouse experiments were performed. The results suggested that the proposed region reconstruction method was able to reconstruct the features of the fluorescent regions accurately and effectively, and the proposed method was able to be feasibly adopted in in vivo application.
KeywordFluorescence Molecular Tomography Piecewise Constant Level Set 3-d Reconstruction
WOS HeadingsScience & Technology ; Technology
WOS KeywordDIFFUSE OPTICAL TOMOGRAPHY ; ELEMENT BASED TOMOGRAPHY ; RAY COMPUTED-TOMOGRAPHY ; LEVEL-SET APPROACH ; IMAGE-RECONSTRUCTION ; L1 REGULARIZATION ; IN-VIVO ; BIOLUMINESCENCE TOMOGRAPHY ; CONJUGATE-GRADIENT ; SPARSITY
Indexed BySCI
Language英语
WOS Research AreaEngineering
WOS SubjectEngineering, Biomedical
WOS IDWOS:000356310700015
Citation statistics
Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/7913
Collection中国科学院分子影像重点实验室
Affiliation1.Beijing Jiaotong Univ, Beijing 100044, Peoples R China
2.Beijing Jiaotong Univ, Sch Comp & Informat Technol, Dept Biomed Engn, Beijing 100044, Peoples R China
3.Chinese Acad Sci, Beijing 100864, Peoples R China
4.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
An, Yu,Liu, Jie,Zhang, Guanglei,et al. A Novel Region Reconstruction Method for Fluorescence Molecular Tomography[J]. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING,2015,62(7):1818-1826.
APA An, Yu.,Liu, Jie.,Zhang, Guanglei.,Ye, Jinzuo.,Du, Yang.,...&Tian, Jie.(2015).A Novel Region Reconstruction Method for Fluorescence Molecular Tomography.IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING,62(7),1818-1826.
MLA An, Yu,et al."A Novel Region Reconstruction Method for Fluorescence Molecular Tomography".IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING 62.7(2015):1818-1826.
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