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GX1-conjugated poly(lactic acid) nanoparticles encapsulating Endostar for improved in vivo anticolorectal cancer treatment
Du, Yang1; Zhang, Qian1; Jing, Lijia2; Liang, Xiaolong2; Chi, Chongwei1; Li, Yaqian1; Yang, Xin1; Dai, Zhifei2; Tian, Jie1
Source PublicationINTERNATIONAL JOURNAL OF NANOMEDICINE
2015
Volume10Pages:3791-3802
SubtypeArticle
AbstractTumor angiogenesis plays a key role in tumor growth and metastasis; thus, targeting tumor-associated angiogenesis is an important goal in cancer therapy. However, the efficient delivery of drugs to tumors remains a key issue in antiangiogenesis therapy. GX1, a peptide identified by phage-display technology, is a novel tumor vasculature endothelium-specific ligand and possesses great potential as a targeted vector and antiangiogenic agent in the diagnosis and treatment of human cancers. Endostar, a novel recombinant human endostatin, has been shown to inhibit tumor angiogenesis. In this study, we developed a theranostic agent composed of GX1-conjugated poly(lactic acid) nanoparticles encapsulating Endostar (GPENs) and labeled with the near-infrared dye IRDye 800CW to improve colorectal tumor targeting and treatment efficacy in vivo. The in vivo fluorescence molecular imaging data showed that GPENs (IRDye 800CW) more specifically targeted tumors than free IRDye 800CW in colorectal tumor-bearing mice. Moreover, the antitumor efficacy was evaluated by bioluminescence imaging and immunohistology, revealing that GPENs possessed improved antitumor efficacy on subcutaneous colorectal xenografts compared to other treatment groups. Thus, our study showed that GPENs, a novel GX1 peptide guided form of nanoscale Endostar, can be used as a theranostic agent to facilitate more efficient targeted therapy and enable real-time monitoring of therapeutic efficacy in vivo.
KeywordGx1 Peptide Endostar Colorectal Cancer Angiogenesis Irdye 800cw Molecular Imaging
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordRECOMBINANT HUMAN ENDOSTATIN ; GASTRIC-CANCER ; INTEGRIN ALPHA(V)BETA(3) ; ANTIANGIOGENIC THERAPY ; TUMOR ANGIOGENESIS ; TARGETED THERAPY ; DRUG-DELIVERY ; VASCULATURE ; ACTIVATION ; RESISTANCE
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics ; Pharmacology & Pharmacy
WOS SubjectNanoscience & Nanotechnology ; Pharmacology & Pharmacy
WOS IDWOS:000355177500001
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Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/7927
Collection中国科学院分子影像重点实验室
Affiliation1.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex, Key Lab Mol Imaging, Beijing 100190, Peoples R China
2.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Du, Yang,Zhang, Qian,Jing, Lijia,et al. GX1-conjugated poly(lactic acid) nanoparticles encapsulating Endostar for improved in vivo anticolorectal cancer treatment[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2015,10:3791-3802.
APA Du, Yang.,Zhang, Qian.,Jing, Lijia.,Liang, Xiaolong.,Chi, Chongwei.,...&Tian, Jie.(2015).GX1-conjugated poly(lactic acid) nanoparticles encapsulating Endostar for improved in vivo anticolorectal cancer treatment.INTERNATIONAL JOURNAL OF NANOMEDICINE,10,3791-3802.
MLA Du, Yang,et al."GX1-conjugated poly(lactic acid) nanoparticles encapsulating Endostar for improved in vivo anticolorectal cancer treatment".INTERNATIONAL JOURNAL OF NANOMEDICINE 10(2015):3791-3802.
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