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Compromised small-world efficiency of structural brain networks in schizophrenic patients and their unaffected parents
Yan, Hao1,2,3; Tian, Lin1,2,3; Wang, Qifeng4; Zhao, Qiang5; Yue, Weihua1,2,3; Yan, Jun1,2,3; Liu, Bing4; Zhang, Dai1,2,3,6,7
Source PublicationNEUROSCIENCE BULLETIN
2015-06-01
Volume31Issue:3Pages:275-287
SubtypeArticle
AbstractSeveral lines of evidence suggest that efficient information integration between brain regions is disrupted in schizophrenia. Abnormalities in white matter tracts that interconnect brain regions may be directly relevant to this pathophysiological process. As a complex mental disorder with high heritability, mapping abnormalities in patients and their first-degree relatives may help to disentangle the risk factors for schizophrenia. We established a weighted network model of white matter connections using diffusion tensor imaging in 25 nuclear families with schizophrenic probands (19 patients and 41 unaffected parents) and two unrelated groups of normal controls (24 controls matched with patients and 26 controls matched with relatives). The patient group showed lower global efficiency and local efficiency. The decreased regional efficiency was localized in hubs such as the bilateral frontal cortices, bilateral anterior cingulate cortices, and left precuneus. The global efficiency was negatively correlated with cognition scores derived from a 5-factor model of schizophrenic psychopathology. We also found that unaffected parents displayed decreased regional efficiency in the right temporal cortices, left supplementary motor area, left superior temporal pole, and left thalamus. The global efficiency tended to be lower in unaffected parents. Our data suggest that (1) the global efficiency loss in neuroanatomical networks may be associated with the cognitive disturbances in schizophrenia; and (2) genetic vulnerability to schizophrenia may influence the anatomical organization of an individual's brain networks.
KeywordNetwork Analysis Diffusion Tensor Imaging Tractography White Matter Small-world Architecture
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordGRAPH-THEORETICAL ANALYSIS ; HUMAN CEREBRAL-CORTEX ; WHITE-MATTER ; FUNCTIONAL NETWORKS ; CORTICAL NETWORKS ; FIBER INTEGRITY ; GENETIC RISK ; CONNECTIVITY ; RELATIVES ; SIBLINGS
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000355619700001
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/7933
Collection脑网络组研究中心
Affiliation1.Peking Univ, Hosp 6, Beijing 100191, Peoples R China
2.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, LIAMA Ctr Computat Med, Beijing 100190, Peoples R China
5.Peking Univ, Hosp 3, Dept Radiol, Beijing 100191, Peoples R China
6.Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
7.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Yan, Hao,Tian, Lin,Wang, Qifeng,et al. Compromised small-world efficiency of structural brain networks in schizophrenic patients and their unaffected parents[J]. NEUROSCIENCE BULLETIN,2015,31(3):275-287.
APA Yan, Hao.,Tian, Lin.,Wang, Qifeng.,Zhao, Qiang.,Yue, Weihua.,...&Zhang, Dai.(2015).Compromised small-world efficiency of structural brain networks in schizophrenic patients and their unaffected parents.NEUROSCIENCE BULLETIN,31(3),275-287.
MLA Yan, Hao,et al."Compromised small-world efficiency of structural brain networks in schizophrenic patients and their unaffected parents".NEUROSCIENCE BULLETIN 31.3(2015):275-287.
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