| The catechol-o-methyltransferase Val(158)Met polymorphism modulates the intrinsic functional network centrality of the parahippocampal cortex in healthy subjects | |
Zhang, Xiaolong1; Li, Jin1,2 ; Qin, Wen3; Yu, Chunshui3; Liu, Bing1,2; Jiang, Tianzi1,2,4,5
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| 发表期刊 | SCIENTIFIC REPORTS
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| 2015-06-09 | |
| 卷号 | 5 |
| 文章类型 | Article |
| 摘要 | The influence of catechol-o-methyltransferase (COMT) Val(158)Met on brain activation and functional connectivity has been widely reported. However, voxel-wise effects of this genotype on resting-state brain networks remain unclear. Here, we used resting-state fMRI and eigenvector centrality to examine the effects of COMT Val(158)Met genotypes on the connection patterns of the brain network and working memory (WM) in healthy, young Val/Val and Met carrier subjects. There were significant differences in the performance level on the 2-back WM task between the different COMT genotypes: Val/Val individuals exhibited a higher correct rate compared to the Met carriers. A two-sample t test was used to examine the differences in the eigenvector centrality maps, using age and gender as covariates of no interest, between the Val/Val and Met carriers. We found that the Val/Val individuals exhibited significantly higher eigenvector centrality compared to the Met carriers in the left parahippocampal cortex. Furthermore, a significantly positive correlation between the mean eigenvector centrality of the significant cluster and the correct rate of the 2-back WM task was observed. By using a voxel-wise data-driven method, our findings may provide plausible implications regarding individual differences in the genetic contribution of COMT Val(158)Met to the brain network and cognition. |
| WOS标题词 | Science & Technology |
| 关键词[WOS] | WORKING-MEMORY PERFORMANCE ; VAL(108/158) MET GENOTYPE ; RESTING-STATE FMRI ; ALZHEIMERS-DISEASE ; BRAIN-FUNCTION ; YOUNG ADULTS ; COMT ; CONNECTIVITY ; SCHIZOPHRENIA ; SUBREGIONS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| WOS记录号 | WOS:000356080400001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.ia.ac.cn/handle/173211/7935 |
| 专题 | 脑图谱与类脑智能实验室_脑网络组研究 |
| 作者单位 | 1.Chinese Acad Sci, Brainnetome Ctr, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China 3.Tianjin Med Univ, Dept Radiol, Gen Hosp, Tianjin 300052, Peoples R China 4.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia 5.Univ Elect Sci & Technol China, Minist Educ, Sch Life Sci & Technol, Key Lab NeuroInformat, Chengdu 610054, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xiaolong,Li, Jin,Qin, Wen,et al. The catechol-o-methyltransferase Val(158)Met polymorphism modulates the intrinsic functional network centrality of the parahippocampal cortex in healthy subjects[J]. SCIENTIFIC REPORTS,2015,5. |
| APA | Zhang, Xiaolong,Li, Jin,Qin, Wen,Yu, Chunshui,Liu, Bing,&Jiang, Tianzi.(2015).The catechol-o-methyltransferase Val(158)Met polymorphism modulates the intrinsic functional network centrality of the parahippocampal cortex in healthy subjects.SCIENTIFIC REPORTS,5. |
| MLA | Zhang, Xiaolong,et al."The catechol-o-methyltransferase Val(158)Met polymorphism modulates the intrinsic functional network centrality of the parahippocampal cortex in healthy subjects".SCIENTIFIC REPORTS 5(2015). |
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