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Efficacy of a Chinese herbal formula in patients with stable angina pectoris based on doctor and patient reported outcomes
Li, Xiao-ke1,2; Jing, Lu3; Lu, Peng4; He, Qing-yong1; Xiong, Xing-jiang1; Yao, Kui-wu1; Guo, Li-li1; Wang, Jie1; Chen, Jian-xin2
2012-06-01
发表期刊AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY
卷号6期号:24页码:1799-1804
文章类型Article
摘要This research aimed at evaluating the clinical curative effect of Blood Mansion Stasis-Expelling Decoction and its refining prescription on stable angina pectoris through double-blind randomized controlled trial based on doctor and patient reported outcomes. Patients (92) were randomly grouped into Groups A, B, and C, and were separately given Blood Mansion Stasis-Expelling Decoction, refined Blood Mansion Stasis-Expelling Decoction and placebo, and they were evaluated before and after treatment, though, doctor and patient reported outcomes. The results showed that in doctor reported outcomes (DRO) aspect Blood Mansion Stasis-Expelling Decoction and its refining prescription had significant curative effect on angina (P < 0.05) when compared with placebo and reduced the patients' nitroglycerin consumption (P < 0.01), blood viscosity, platelet adhesion rate (PAR), and serum IL-6 level (P < 0.05 or P < 0.01), and raised their NO level (P < 0.05), while Blood Mansion Stasis-Expelling Decoction could raise the patients' erythrocyte deformation rate (EDR) and tissue plasminogen activator (t-PA) level (P < 0.05). In patient reported outcomes (PRO) aspect, Blood Mansion Stasis-Expelling Decoction and its refining prescription could improve angina stability of the stable angina pectoris patients, angina frequency and the satisfaction about the whole treatment (P<0.01 or P<0.05), and especially, work better on the patients' angina frequency than placebo (P < 0.05). The result showed that Blood Mansion Stasis-Expelling Decoction and its refining prescription have significant curative effect on stable angina pectoris through reducing inflammatory mediators and improving hemorheology condition and vascular endothelial function. Double-blind randomized controlled trial based on doctor and patient reported outcomes is an effective method to evaluate the curative effect of Chinese herbal formulae.
关键词Blood Mansion Stasis-expelling Decoction Patient Reported Outcomes Doctor Reported Outcomes Stable Angina Pectoris Seattle Angina Questionnaire (Saq) Traditional Chinese Medicine Double-blind Randomized Controlled Trial
WOS标题词Science & Technology ; Life Sciences & Biomedicine
收录类别SCI
语种英语
WOS研究方向Pharmacology & Pharmacy
WOS类目Pharmacology & Pharmacy
WOS记录号WOS:000307967000013
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/8002
专题综合信息系统研究中心
作者单位1.China Acad Chinese Med Sci, Guanganmen Hosp, Beijing 100053, Peoples R China
2.Beijing Univ Chinese Med, Beijing 100029, Peoples R China
3.China Acad Chinese Med Sci, Xiyuan Hosp, Beijing 100091, Peoples R China
4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
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Li, Xiao-ke,Jing, Lu,Lu, Peng,et al. Efficacy of a Chinese herbal formula in patients with stable angina pectoris based on doctor and patient reported outcomes[J]. AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY,2012,6(24):1799-1804.
APA Li, Xiao-ke.,Jing, Lu.,Lu, Peng.,He, Qing-yong.,Xiong, Xing-jiang.,...&Chen, Jian-xin.(2012).Efficacy of a Chinese herbal formula in patients with stable angina pectoris based on doctor and patient reported outcomes.AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY,6(24),1799-1804.
MLA Li, Xiao-ke,et al."Efficacy of a Chinese herbal formula in patients with stable angina pectoris based on doctor and patient reported outcomes".AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY 6.24(2012):1799-1804.
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