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The enhanced chemotherapeutic effects of doxorubicin loaded PEG coated TiO2 nanocarriers in an orthotopic breast tumor bearing mouse model
Du, Yang1; Ren, Wenzhi2,3; Li, Yaqian1,4; Zhang, Qian1; Zeng, Leyong2,3; Chi, Chongwei1; Wu, Aiguo2,3; Tian, Jie1
2015
发表期刊JOURNAL OF MATERIALS CHEMISTRY B
卷号3期号:8页码:1518-1528
文章类型Article
摘要Many chemotherapeutics used for cancer treatments encounter issues during delivery to tumors in vivo and have high levels of systemic toxicity. One of the most prominent progresses in improving drug delivery efficiency is through exploring various types of nanoparticles (NPs) as drug carriers. Recent studies have demonstrated that titanium dioxide (TiO2) nanocarriers have potential for drug delivery and therapy even in multidrug resistant cancers in vitro. Moreover, it was proved that the anticancer activity of doxorubicin (DOX) was enhanced by loading onto TiO2 nanoparticles in breast cancer cells in vitro. However, there is no evidence from the animal model in vivo, which is a critical step for their further clinical applications. The aim of this study was to explore novel TiO2-PEG-DOX nanoparticles, the DOX loaded polyethylene glycol (PEG) coated TiO2 nanocarriers, and investigate their potential application in enabling controlled drug release and enhancing the chemotherapeutic efficacy of DOX in the orthotopic breast tumor bearing mice. The tumor growth and drug treatment efficacy were dynamically monitored by bioluminescence imaging (BLI), and the safety of NPs for in vivo usage was also evaluated. It was found that TiO2-PEG-DOX nanoparticles possessed improved antitumor efficacy without observable side effects compared to the free DOX treatment. Our study suggested that the PEG coated TiO2 nanocarrier is a safe and potential platform for the efficient drug delivery and minimizing the systemic toxicity of chemotherapeutic agents. It has been proved for the first time that TiO2-based nanocarriers enhance the chemotherapeutic effects of doxorubicin in vivo.
WOS标题词Science & Technology ; Technology
关键词[WOS]RESPONSIVE DRUG-DELIVERY ; IN-VITRO ; MULTIDRUG-RESISTANCE ; TITANIUM-DIOXIDE ; CANCER CELLS ; NANOPARTICLES ; THERAPY ; DESIGN ; SIRNA
收录类别SCI
语种英语
WOS研究方向Materials Science
WOS类目Materials Science, Biomaterials
WOS记录号WOS:000349755500007
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/8046
专题中国科学院分子影像重点实验室
作者单位1.Chinese Acad Sci, Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Inst Automat, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Lab Magnet Mat & Devices, Ningbo Inst Mat Technol & Engn, Ningbo 315201, Zhejiang, Peoples R China
3.Chinese Acad Sci, Div Funct Mat & Nanodevices, Ningbo Inst Mat Technol & Engn, Ningbo 315201, Zhejiang, Peoples R China
4.Harbin Univ Sci & Technol, Harbin, Peoples R China
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Du, Yang,Ren, Wenzhi,Li, Yaqian,et al. The enhanced chemotherapeutic effects of doxorubicin loaded PEG coated TiO2 nanocarriers in an orthotopic breast tumor bearing mouse model[J]. JOURNAL OF MATERIALS CHEMISTRY B,2015,3(8):1518-1528.
APA Du, Yang.,Ren, Wenzhi.,Li, Yaqian.,Zhang, Qian.,Zeng, Leyong.,...&Tian, Jie.(2015).The enhanced chemotherapeutic effects of doxorubicin loaded PEG coated TiO2 nanocarriers in an orthotopic breast tumor bearing mouse model.JOURNAL OF MATERIALS CHEMISTRY B,3(8),1518-1528.
MLA Du, Yang,et al."The enhanced chemotherapeutic effects of doxorubicin loaded PEG coated TiO2 nanocarriers in an orthotopic breast tumor bearing mouse model".JOURNAL OF MATERIALS CHEMISTRY B 3.8(2015):1518-1528.
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