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Bridging Integrator 1 (BIN1) Genotype Effects on Working Memory, Hippocampal Volume, and Functional Connectivity in Young Healthy Individuals
Zhang, Xiaolong1,2; Yu, Jin-Tai3,4; Li, Jin1,2; Wang, Chao5; Tan, Lan3; Liu, Bing1,2; Jiang, Tianzi1,2,5,6
2015-06-01
发表期刊NEUROPSYCHOPHARMACOLOGY
卷号40期号:7页码:1794-1803
文章类型Article
摘要Alzheimer's disease (AD) is the most common form of dementia and exhibits a considerable level of heritability. The bridging integrator 1 (BIN1) gene has recently been identified in several large genome-wide association studies (GWAS) as the second most important risk locus for AD following apolipoprotein E (APOE). However, how and when the established genetic risk locus BIN1 rs744373 confers risk to late-onset AD has yet to be determined. Here using an imaging genetic strategy in large-sample Chinese subjects, we show that healthy homozygous carriers of the rs744373 risk allele exhibit worse high-load working memory (WM) performance, larger hippocampal volume and lower functional connectivity between the bilateral hippocampus and the right dorsolateral prefrontal cortex (DLPFC), mirroring clinical evidence of disturbed memory and connectivity in patients. Our findings demonstrate that rs744373 itself or a variation in linkage disequilibrium may provide a neurogenetic mechanism for BIN1 while further validating the possibility of combining genetic and neuroimaging strategies to monitor individuals at risk for AD.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]MILD COGNITIVE IMPAIRMENT ; VOXEL-BASED MORPHOMETRY ; MEDIAL TEMPORAL-LOBE ; ALZHEIMERS-DISEASE ; PREFRONTAL CORTEX ; EPSILON-4 ALLELE ; BRAIN ACTIVATION ; APOLIPOPROTEIN-E ; COMMON VARIANTS ; RISK VARIANT
收录类别SCI
语种英语
WOS研究方向Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
WOS类目Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
WOS记录号WOS:000354321600025
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/8075
专题脑网络组研究中心
作者单位1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Qingdao Univ, Qingdao Municipal Hosp, Sch Med, Dept Neurol, Qingdao 266071, Peoples R China
4.Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, San Francisco, CA USA
5.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China
6.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
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Zhang, Xiaolong,Yu, Jin-Tai,Li, Jin,et al. Bridging Integrator 1 (BIN1) Genotype Effects on Working Memory, Hippocampal Volume, and Functional Connectivity in Young Healthy Individuals[J]. NEUROPSYCHOPHARMACOLOGY,2015,40(7):1794-1803.
APA Zhang, Xiaolong.,Yu, Jin-Tai.,Li, Jin.,Wang, Chao.,Tan, Lan.,...&Jiang, Tianzi.(2015).Bridging Integrator 1 (BIN1) Genotype Effects on Working Memory, Hippocampal Volume, and Functional Connectivity in Young Healthy Individuals.NEUROPSYCHOPHARMACOLOGY,40(7),1794-1803.
MLA Zhang, Xiaolong,et al."Bridging Integrator 1 (BIN1) Genotype Effects on Working Memory, Hippocampal Volume, and Functional Connectivity in Young Healthy Individuals".NEUROPSYCHOPHARMACOLOGY 40.7(2015):1794-1803.
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