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Decreased functional connectivity between the mediodorsal thalamus and default mode network in patients with disorders of consciousness
He, J. H.1; Cui, Y.2,3; Song, M.2,3; Yang, Y.1; Dang, Y. Y.1; Jiang, T. Z.2,3,4,5; Xu, R. X.1
2015-03-01
发表期刊ACTA NEUROLOGICA SCANDINAVICA
卷号131期号:3页码:145-151
文章类型Article
摘要Background - Interactions between the thalamus and the cortex play an important role in consciousness. The thalamus as a homogenous structure is less strongly connected with the default mode network (DMN) in patients with disorders of consciousness (DOC), but the roles of specific thalamic nuclei are not clear. The purpose of this study was to investigate the functional connectivity between individual thalamic nuclei and the DMN in DOC patients. Methods - Nine DOC patients and nine age-matched healthy controls were scanned with functional magnetic resonance imaging (fMRI) at resting state. Data-driven independent component analysis and hypothesis-driven region of interest-based correlation analysis were performed. Results - In comparison with healthy controls, DOC patients had significantly decreased functional connectivity between the mediodorsal thalamus and brain areas within the DMN, including the medial prefrontal cortex and posterior cingulate cortex/precuneus. Patients and controls did not show significant differences in functional connectivity in other thalamic nuclei. Conclusion - Our results suggest that functional connections between the mediodorsal thalamus and the DMN may play important roles in the pathogenesis of DOC.
关键词Disorders Of Consciousness Thalamus Default Mode Network Functional Connectivity Functional Magnetic Resonance Imaging
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]MONKEY RETROSPLENIAL CORTEX ; PREFRONTAL CORTEX ; BRAIN ; ORGANIZATION ; DISEASE ; LEVEL ; STATE
收录类别SCI
语种英语
WOS研究方向Neurosciences & Neurology
WOS类目Clinical Neurology
WOS记录号WOS:000351164300001
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/8088
专题脑网络组研究中心
作者单位1.Beijing Army Gen Hosp, Dept Neurosurg, Beijing 100700, Peoples R China
2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
4.Univ Elect Sci & Technol China, Minist Educ, Sch Life Sci & Technol, Key Lab NeuroInformat, Chengdu 610054, Peoples R China
5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
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GB/T 7714
He, J. H.,Cui, Y.,Song, M.,et al. Decreased functional connectivity between the mediodorsal thalamus and default mode network in patients with disorders of consciousness[J]. ACTA NEUROLOGICA SCANDINAVICA,2015,131(3):145-151.
APA He, J. H..,Cui, Y..,Song, M..,Yang, Y..,Dang, Y. Y..,...&Xu, R. X..(2015).Decreased functional connectivity between the mediodorsal thalamus and default mode network in patients with disorders of consciousness.ACTA NEUROLOGICA SCANDINAVICA,131(3),145-151.
MLA He, J. H.,et al."Decreased functional connectivity between the mediodorsal thalamus and default mode network in patients with disorders of consciousness".ACTA NEUROLOGICA SCANDINAVICA 131.3(2015):145-151.
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