CASIA OpenIR  > 脑网络组研究中心
Impacts of PICALM and CLU variants associated with Alzheimer's disease on the functional connectivity of the hippocampus in healthy young adults
Zhang, Peng1,2; Qin, Wen1,2; Wang, Dawei1,2; Liu, Bing3,4; Zhang, Yunting1,2; Jiang, Tianzi3,4; Yu, Chunshui1,2
2015-05-01
发表期刊Brain Structure & Function
卷号220期号:3页码:1463-1475
文章类型Article
摘要PICALM rs3851179 and CLU rs11136000 have been recently associated with Alzheimer's disease (AD). Investigating the effects of these genetic variants on the resting-state functional connectivity (rsFC) of the hippocampus may provide new insight into AD pathogenesis. We investigated the main effects and interactions of these two genetic variants on hippocampal rsFC in 283 healthy young adults. The hippocampus showed positive rsFC with the default mode network and negative rsFC with the fronto-parietal network. Risk PICALM G-allele carriers showed weaker negative rsFC compared with AA carriers, whereas risk CLU-CC carriers exhibited stronger positive and negative rsFC than T-allele carriers. There existed complex interactions between PICALM and CLU on the negative rsFC of the hippocampus. Moreover, we found an allele-dependent effect of CLU on hippocampal connectivity when an additive genetic model was applied to CLU. Most of these effects remained significant even after controlling for individual ApoE status. Our results suggest that PICALM and CLU risk genotypes exert differential impacts on the hippocampal rsFC in healthy young subjects. The complex interactions between PICALM and CLU should be considered when investigating the impact of these two genetic variants on the brain.
关键词Picalm Clu Hippocampus Functional Connectivity Fmri Snp
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]CLATHRIN-MEDIATED ENDOCYTOSIS ; RESTING-STATE FMRI ; GENOME-WIDE ASSOCIATION ; DEFAULT-MODE NETWORK ; EPISODIC MEMORY ; RISK VARIANT ; IDENTIFIES VARIANTS ; GENETIC-CONTROL ; IN-VIVO ; BRAIN
收录类别SCI
语种英语
WOS研究方向Anatomy & Morphology ; Neurosciences & Neurology
WOS类目Anatomy & Morphology ; Neurosciences
WOS记录号WOS:000353515200016
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/8110
专题脑网络组研究中心
作者单位1.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China
2.Tianjin Med Univ, Gen Hosp, Tianjin Key Lab Funct Imaging, Tianjin 300052, Peoples R China
3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Peng,Qin, Wen,Wang, Dawei,et al. Impacts of PICALM and CLU variants associated with Alzheimer's disease on the functional connectivity of the hippocampus in healthy young adults[J]. Brain Structure & Function,2015,220(3):1463-1475.
APA Zhang, Peng.,Qin, Wen.,Wang, Dawei.,Liu, Bing.,Zhang, Yunting.,...&Yu, Chunshui.(2015).Impacts of PICALM and CLU variants associated with Alzheimer's disease on the functional connectivity of the hippocampus in healthy young adults.Brain Structure & Function,220(3),1463-1475.
MLA Zhang, Peng,et al."Impacts of PICALM and CLU variants associated with Alzheimer's disease on the functional connectivity of the hippocampus in healthy young adults".Brain Structure & Function 220.3(2015):1463-1475.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhang, Peng]的文章
[Qin, Wen]的文章
[Wang, Dawei]的文章
百度学术
百度学术中相似的文章
[Zhang, Peng]的文章
[Qin, Wen]的文章
[Wang, Dawei]的文章
必应学术
必应学术中相似的文章
[Zhang, Peng]的文章
[Qin, Wen]的文章
[Wang, Dawei]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。