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Impacts of PICALM and CLU variants associated with Alzheimer's disease on the functional connectivity of the hippocampus in healthy young adults
Zhang, Peng1,2; Qin, Wen1,2; Wang, Dawei1,2; Liu, Bing3,4; Zhang, Yunting1,2; Jiang, Tianzi3,4; Yu, Chunshui1,2
Source PublicationBrain Structure & Function
2015-05-01
Volume220Issue:3Pages:1463-1475
SubtypeArticle
AbstractPICALM rs3851179 and CLU rs11136000 have been recently associated with Alzheimer's disease (AD). Investigating the effects of these genetic variants on the resting-state functional connectivity (rsFC) of the hippocampus may provide new insight into AD pathogenesis. We investigated the main effects and interactions of these two genetic variants on hippocampal rsFC in 283 healthy young adults. The hippocampus showed positive rsFC with the default mode network and negative rsFC with the fronto-parietal network. Risk PICALM G-allele carriers showed weaker negative rsFC compared with AA carriers, whereas risk CLU-CC carriers exhibited stronger positive and negative rsFC than T-allele carriers. There existed complex interactions between PICALM and CLU on the negative rsFC of the hippocampus. Moreover, we found an allele-dependent effect of CLU on hippocampal connectivity when an additive genetic model was applied to CLU. Most of these effects remained significant even after controlling for individual ApoE status. Our results suggest that PICALM and CLU risk genotypes exert differential impacts on the hippocampal rsFC in healthy young subjects. The complex interactions between PICALM and CLU should be considered when investigating the impact of these two genetic variants on the brain.
KeywordPicalm Clu Hippocampus Functional Connectivity Fmri Snp
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordCLATHRIN-MEDIATED ENDOCYTOSIS ; RESTING-STATE FMRI ; GENOME-WIDE ASSOCIATION ; DEFAULT-MODE NETWORK ; EPISODIC MEMORY ; RISK VARIANT ; IDENTIFIES VARIANTS ; GENETIC-CONTROL ; IN-VIVO ; BRAIN
Indexed BySCI
Language英语
WOS Research AreaAnatomy & Morphology ; Neurosciences & Neurology
WOS SubjectAnatomy & Morphology ; Neurosciences
WOS IDWOS:000353515200016
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/8110
Collection脑网络组研究中心
Affiliation1.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China
2.Tianjin Med Univ, Gen Hosp, Tianjin Key Lab Funct Imaging, Tianjin 300052, Peoples R China
3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Peng,Qin, Wen,Wang, Dawei,et al. Impacts of PICALM and CLU variants associated with Alzheimer's disease on the functional connectivity of the hippocampus in healthy young adults[J]. Brain Structure & Function,2015,220(3):1463-1475.
APA Zhang, Peng.,Qin, Wen.,Wang, Dawei.,Liu, Bing.,Zhang, Yunting.,...&Yu, Chunshui.(2015).Impacts of PICALM and CLU variants associated with Alzheimer's disease on the functional connectivity of the hippocampus in healthy young adults.Brain Structure & Function,220(3),1463-1475.
MLA Zhang, Peng,et al."Impacts of PICALM and CLU variants associated with Alzheimer's disease on the functional connectivity of the hippocampus in healthy young adults".Brain Structure & Function 220.3(2015):1463-1475.
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