Impacts of PICALM and CLU variants associated with Alzheimer's disease on the functional connectivity of the hippocampus in healthy young adults

	Impacts of PICALM and CLU variants associated with Alzheimer's disease on the functional connectivity of the hippocampus in healthy young adults
	Zhang, Peng 1,2; Qin, Wen 1,2; Wang, Dawei 1,2; Liu, Bing3,4 ; Zhang, Yunting 1,2; Jiang, Tianzi3,4 ; Yu, Chunshui 1,2
发表期刊	Brain Structure & Function
	2015-05-01
卷号	220 期号:3 页码:1463-1475
文章类型	Article
摘要	PICALM rs3851179 and CLU rs11136000 have been recently associated with Alzheimer's disease (AD). Investigating the effects of these genetic variants on the resting-state functional connectivity (rsFC) of the hippocampus may provide new insight into AD pathogenesis. We investigated the main effects and interactions of these two genetic variants on hippocampal rsFC in 283 healthy young adults. The hippocampus showed positive rsFC with the default mode network and negative rsFC with the fronto-parietal network. Risk PICALM G-allele carriers showed weaker negative rsFC compared with AA carriers, whereas risk CLU-CC carriers exhibited stronger positive and negative rsFC than T-allele carriers. There existed complex interactions between PICALM and CLU on the negative rsFC of the hippocampus. Moreover, we found an allele-dependent effect of CLU on hippocampal connectivity when an additive genetic model was applied to CLU. Most of these effects remained significant even after controlling for individual ApoE status. Our results suggest that PICALM and CLU risk genotypes exert differential impacts on the hippocampal rsFC in healthy young subjects. The complex interactions between PICALM and CLU should be considered when investigating the impact of these two genetic variants on the brain.
关键词	Picalm Clu Hippocampus Functional Connectivity Fmri Snp
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	CLATHRIN-MEDIATED ENDOCYTOSIS ; RESTING-STATE FMRI ; GENOME-WIDE ASSOCIATION ; DEFAULT-MODE NETWORK ; EPISODIC MEMORY ; RISK VARIANT ; IDENTIFIES VARIANTS ; GENETIC-CONTROL ; IN-VIVO ; BRAIN
收录类别	SCI
语种	英语
WOS研究方向	Anatomy & Morphology ; Neurosciences & Neurology
WOS类目	Anatomy & Morphology ; Neurosciences
WOS记录号	WOS:000353515200016
引用统计	被引频次：26[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/8110
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Tianjin Med Univ, Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China 2.Tianjin Med Univ, Gen Hosp, Tianjin Key Lab Funct Imaging, Tianjin 300052, Peoples R China 3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Peng,Qin, Wen,Wang, Dawei,et al. Impacts of PICALM and CLU variants associated with Alzheimer's disease on the functional connectivity of the hippocampus in healthy young adults[J]. Brain Structure & Function,2015,220(3):1463-1475.
APA	Zhang, Peng.,Qin, Wen.,Wang, Dawei.,Liu, Bing.,Zhang, Yunting.,...&Yu, Chunshui.(2015).Impacts of PICALM and CLU variants associated with Alzheimer's disease on the functional connectivity of the hippocampus in healthy young adults.Brain Structure & Function,220(3),1463-1475.
MLA	Zhang, Peng,et al."Impacts of PICALM and CLU variants associated with Alzheimer's disease on the functional connectivity of the hippocampus in healthy young adults".Brain Structure & Function 220.3(2015):1463-1475.