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Determination of the Posterior Boundary of Wernicke's Area Based on Multimodal Connectivity Profiles
Wang, Jiaojian1; Fan, Lingzhong2,3; Wang, Yinyan4; Xu, Wenting1; Jiang, Tao4; Fox, Peter T.5; Eickhoff, Simon B.6,7; Yu, Chunshui8; Jiang, Tianzi1,2,3,9
2015-05-01
发表期刊HUMAN BRAIN MAPPING
卷号36期号:5页码:1908-1924
文章类型Article
摘要Wernicke's area is one of the most important language regions and has been widely studied in both basic research and clinical neurology. However, its exact anatomy has been controversial. In this study, we proposed to address the anatomy of Wernicke's area by investigating different connectivity profiles. First, the posterior superior temporal gyrus (STG), traditionally called Wernicke's area, was parcellated into three component subregions with diffusion MRI. Then, whole-brain anatomical connectivity, resting-state functional connectivity (RSFC) and meta-analytic connectivity modeling (MACM) analyses were used to establish the anatomical, resting-state and task-related coactivation network of each subregion to identify which subregions participated in the language network. In addition, behavioral domain analysis, meta-analyses of semantics, execution speech, and phonology and intraoperative electrical stimulation were used to determine which subregions were involved in language processing. Anatomical connectivity, RSFC and MACM analyses consistently identified that the two anterior subregions in the posterior STG primarily participated in the language network, whereas the most posterior subregion in the temporoparietal junction area primarily participated in the default mode network. Moreover, the behavioral domain analyses, meta-analyses of semantics, execution speech and phonology and intraoperative electrical stimulation mapping also confirmed that only the two anterior subregions were involved in language processing, whereas the most posterior subregion primarily participated in social cognition. Our findings revealed a convergent posterior anatomical border for Wernicke's area and indicated that the brain's functional subregions can be identified on the basis of its specific structural and functional connectivity patterns. Hum Brain Mapp 36:1908-1924, 2015. (c) 2015 Wiley Periodicals, Inc.
关键词Parcellation Anatomical Connectivity Resting-state Meta-analytic Connectivity Modeling Behavioral Domain Analysis Intraoperative Electrical Stimulation
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]SPEECH-PERCEPTION ; FUNCTIONAL CONNECTIVITY ; FRONTAL-CORTEX ; HUMAN BRAIN ; PARIETAL LOBULE ; HUMAN AMYGDALA ; ANGULAR GYRUS ; MOTOR CORTEX ; DEFAULT MODE ; IN-VIVO
收录类别SCI
语种英语
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000353068300020
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/8112
专题脑网络组研究中心
作者单位1.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China
2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
4.Capital Med Univ, Beijing Neurosurg Inst, Beijing, Peoples R China
5.Univ Texas Hlth Sci Ctr San Antonio, Res Imaging Inst, San Antonio, TX 78229 USA
6.Forschungszentrum Julich, Inst Neurosci & Med INM 1, D-52425 Julich, Germany
7.Univ Dusseldorf, Inst Clin Neurosci & Med Psychol, Dusseldorf, Germany
8.Tianjin Med Univ, Dept Radiol, Gen Hosp, Tianjin, Peoples R China
9.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
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Wang, Jiaojian,Fan, Lingzhong,Wang, Yinyan,et al. Determination of the Posterior Boundary of Wernicke's Area Based on Multimodal Connectivity Profiles[J]. HUMAN BRAIN MAPPING,2015,36(5):1908-1924.
APA Wang, Jiaojian.,Fan, Lingzhong.,Wang, Yinyan.,Xu, Wenting.,Jiang, Tao.,...&Jiang, Tianzi.(2015).Determination of the Posterior Boundary of Wernicke's Area Based on Multimodal Connectivity Profiles.HUMAN BRAIN MAPPING,36(5),1908-1924.
MLA Wang, Jiaojian,et al."Determination of the Posterior Boundary of Wernicke's Area Based on Multimodal Connectivity Profiles".HUMAN BRAIN MAPPING 36.5(2015):1908-1924.
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