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Prefrontal cortex and the dysconnectivity hypothesis of schizophrenia
Zhou, Yuan1,2; Fan, Lingzhong3,4; Qiu, Chenxiang3,4; Jiang, Tianzi3,4,5,6
2015-04-01
发表期刊NEUROSCIENCE BULLETIN
卷号31期号:2页码:207-219
文章类型Review
摘要Schizophrenia is hypothesized to arise from disrupted brain connectivity. This "dysconnectivity hypothesis" has generated interest in discovering whether there is anatomical and functional dysconnectivity between the prefrontal cortex (PFC) and other brain regions, and how this dysconnectivity is linked to the impaired cognitive functions and aberrant behaviors of schizophrenia. Critical advances in neuroimaging technologies, including diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI), make it possible to explore these issues. DTI affords the possibility to explore anatomical connectivity in the human brain in vivo and fMRI can be used to make inferences about functional connections between brain regions. In this review, we present major advances in the understanding of PFC anatomical and functional dysconnectivity and their implications in schizophrenia. We then briefly discuss future prospects that need to be explored in order to move beyond simple mapping of connectivity changes to elucidate the neuronal mechanisms underlying schizophrenia.
关键词Prefrontal Cortex Schizophrenia Anatomical Connectivity Functional Connectivity
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]TRANSCRANIAL MAGNETIC STIMULATION ; CONNECTIVITY-BASED PARCELLATION ; AUDITORY VERBAL HALLUCINATIONS ; STATE FUNCTIONAL CONNECTIVITY ; WHITE-MATTER ABNORMALITIES ; 1ST EPISODE SCHIZOPHRENIA ; SMALL-WORLD NETWORKS ; DIFFUSION TENSOR ; STRUCTURAL CONNECTIVITY ; FRONTAL-CORTEX
收录类别SCI
语种英语
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000352152800007
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/8131
专题脑网络组研究中心
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Behav Sci, Beijing 100101, Peoples R China
2.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, Beijing 100101, Peoples R China
3.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
6.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China
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Zhou, Yuan,Fan, Lingzhong,Qiu, Chenxiang,et al. Prefrontal cortex and the dysconnectivity hypothesis of schizophrenia[J]. NEUROSCIENCE BULLETIN,2015,31(2):207-219.
APA Zhou, Yuan,Fan, Lingzhong,Qiu, Chenxiang,&Jiang, Tianzi.(2015).Prefrontal cortex and the dysconnectivity hypothesis of schizophrenia.NEUROSCIENCE BULLETIN,31(2),207-219.
MLA Zhou, Yuan,et al."Prefrontal cortex and the dysconnectivity hypothesis of schizophrenia".NEUROSCIENCE BULLETIN 31.2(2015):207-219.
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