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The cortical surface area of the insula mediates the effect of DBH rs7040170 on novelty seeking
Li, Jin1,2; Cui, Yue1,2; Wu, Karen3; Liu, Bing1,2; Zhang, Yun4; Wang, Chao4; Jiang, Tianzi1,2,4,5
2015-08-15
发表期刊NEUROIMAGE
卷号117页码:184-190
文章类型Article
摘要Novelty seeking (NS) is a personality trait important for adaptive functioning, but an excessive level of NS has been linked to psychiatric disorders such as ADHD and substance abuse. Previous research has investigated separately the neural and genetic bases of the NS trait, but results were mixed and neural and genetic bases have yet to be examined within the same study. In this study, we examined the interrelationships among the dopamine beta-hydroxylase (DBH) gene, brain structure, and the NS trait in 359 healthy Han Chinese subjects. We focused on the DBH gene because it encodes a key enzyme for dopamine metabolism, NS is believed to be related to the dopaminergic system and has been reported associated with DBH variation. Results showed a significant positive association between the cortical surface area of the left insula and NS score. Furthermore, the DBH genetic polymorphism at the SNP rs7040170 was strongly associated with both the surface area of the left insula and NS score, with G carriers having a larger left insula surface area and a higher NS score than AA homozygotes. Subsequent path analysis suggested that the insula partially mediated the association between the DBH gene and the NS trait. Our data provided the first evidence for the involvement of the insula in the dopamine-NS relationship. Future studies of molecular mechanisms underlying the NS personality trait and related psychiatric disorders should consider the mediation effect of the neural structure. (C) 2015 Elsevier Inc. All rights reserved.
关键词Novelty Seeking Surface Area Cortical Thickness Insula Dbh
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]DOPAMINE-BETA-HYDROXYLASE ; HUMAN CEREBRAL-CORTEX ; OBSESSIVE-COMPULSIVE DISORDER ; VOXEL-BASED MORPHOMETRY ; PERSONALITY-TRAITS ; INDIVIDUAL-DIFFERENCES ; TYROSINE-HYDROXYLASE ; PARKINSONS-DISEASE ; CIGARETTE-SMOKING ; HARM AVOIDANCE
收录类别SCI
语种英语
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000358045100017
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/8869
专题脑网络组研究中心
作者单位1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Univ Calif Irvine, Dept Psychol & Social Behav, Irvine, CA 92697 USA
4.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab NeuroInformat, Chengdu 610054, Peoples R China
5.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia
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GB/T 7714
Li, Jin,Cui, Yue,Wu, Karen,et al. The cortical surface area of the insula mediates the effect of DBH rs7040170 on novelty seeking[J]. NEUROIMAGE,2015,117:184-190.
APA Li, Jin.,Cui, Yue.,Wu, Karen.,Liu, Bing.,Zhang, Yun.,...&Jiang, Tianzi.(2015).The cortical surface area of the insula mediates the effect of DBH rs7040170 on novelty seeking.NEUROIMAGE,117,184-190.
MLA Li, Jin,et al."The cortical surface area of the insula mediates the effect of DBH rs7040170 on novelty seeking".NEUROIMAGE 117(2015):184-190.
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