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Combination of dynamic C-11-PIB PET and structural MRI improves diagnosis of Alzheimer's disease
Liu, Linwen1,2; Fu, Liping3; Zhang, Xi4; Zhang, Jinming3; Zhang, Xiaojun3; Xu, Baixuan3; Tian, Jiahe3; Fan, Yong1,2
Source PublicationPSYCHIATRY RESEARCH-NEUROIMAGING
2015-08-30
Volume233Issue:2Pages:131-140
SubtypeArticle
AbstractStructural magnetic resonance imaging (sMRI) is an established technique for measuring brain atrophy, and dynamic positron emission tomography with C-11-Pittsburgh compound B (C-11-PIB PET) has the potential to provide both perfusion and amyloid deposition information, It remains unclear, however, how to better combine perfusion, amyloid deposition and morphological information extracted from dynamic C-11-PIB PET and sMRI with the goal of improving the diagnosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI). We adopted a linear sparse support vector machine to build classifiers for distinguishing AD and MCI subjects from cognitively normal (CN) subjects based on different combinations of regional measures extracted from imaging data, including perfusion and amyloid deposition information extracted from early and late frames of C-11-PIB separately, and gray matter volumetric information extracted from sMRI data. The experimental results demonstrated that the classifier built upon the combination of imaging measures extracted from early and late frames of C-11-PIB as well as sMRI achieved the highest classification accuracy in both classification studies of AD (100%) and MCI (85%), indicating that multimodality information could aid in the diagnosis of AD and MCI. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
KeywordPet Imaging Structural Mri Perfusion Amy Loid Alzheimer's Disease
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordMILD COGNITIVE IMPAIRMENT ; PITTSBURGH COMPOUND-B ; DIMENSIONAL PATTERN-CLASSIFICATION ; AMYLOID-BETA ; PIB-PET ; IN-VIVO ; FDG-PET ; ASSOCIATION WORKGROUPS ; NATIONAL INSTITUTE ; CEREBRAL PERFUSION
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology ; Psychiatry
WOS SubjectClinical Neurology ; Neuroimaging ; Psychiatry
WOS IDWOS:000359313300009
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/8895
Collection脑网络组研究中心
Affiliation1.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Dept Nucl Med, Beijing 100853, Peoples R China
4.Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Neurol, Beijing 100853, Peoples R China
First Author AffilicationInstitute of Automation, Chinese Academy of Sciences;  Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Liu, Linwen,Fu, Liping,Zhang, Xi,et al. Combination of dynamic C-11-PIB PET and structural MRI improves diagnosis of Alzheimer's disease[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2015,233(2):131-140.
APA Liu, Linwen.,Fu, Liping.,Zhang, Xi.,Zhang, Jinming.,Zhang, Xiaojun.,...&Fan, Yong.(2015).Combination of dynamic C-11-PIB PET and structural MRI improves diagnosis of Alzheimer's disease.PSYCHIATRY RESEARCH-NEUROIMAGING,233(2),131-140.
MLA Liu, Linwen,et al."Combination of dynamic C-11-PIB PET and structural MRI improves diagnosis of Alzheimer's disease".PSYCHIATRY RESEARCH-NEUROIMAGING 233.2(2015):131-140.
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