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Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy
Liu, Renfa1; Jing, Lijia1,3; Peng, Dong2; Li, Yong3; Tian, Jie2; Dai, Zhifei1
2015
发表期刊THERANOSTICS
卷号5期号:10页码:1144-1153
文章类型Article
摘要The integration of diagnostic and therapeutic functionalities into one nanoplatform shows great promise in cancer therapy. In this research, manganese (II) chelate functionalized copper sulfide nanoparticles were successfully prepared using a facile hydrothermal method. The obtained ultrasmall nanoparticles exhibit excellent photothermal effect and photoaoustic activity. Besides, the high loading content of Mn(II) chelates makes the nanoparticles attractive T1 contrast agent in magnetic resonance imaging (MRI). In vivo photoacoustic imaging (PAI) results showed that the nanoparticles could be efficiently accumulated in tumor site in 24 h after systematic administration, which was further validated by MRI tests. The subsequent photothermal therapy of cancer in vivo was achieved without inducing any observed side effects. Therefore, the copper sulfide nanoparticles functionalized with Mn(II) chelate hold great promise as a theranostic nanomedicine for MR/PA dual-modal imaging guided photothermal therapy of cancer.
关键词Copper Sulfide Nanoparticles Nanotheranostic Agent Photoacoustic Imaging Magnatic Resonance Imaging Photothermal Therapy
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.7150/thno.11754
关键词[WOS]MRI CONTRAST AGENTS ; IN-VIVO ; SYNERGISTIC THERAPY ; THERANOSTIC AGENT ; CANCER-CELLS ; ABLATION ; PLATFORM ; PROBE
收录类别SCI
语种英语
WOS研究方向Research & Experimental Medicine
WOS类目Medicine, Research & Experimental
WOS记录号WOS:000359472700008
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/8914
专题中国科学院分子影像重点实验室
通讯作者Dai, Zhifei
作者单位1.Peking Univ, Dept Biomed Engn, Coll Engn, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
3.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China
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Liu, Renfa,Jing, Lijia,Peng, Dong,et al. Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy[J]. THERANOSTICS,2015,5(10):1144-1153.
APA Liu, Renfa,Jing, Lijia,Peng, Dong,Li, Yong,Tian, Jie,&Dai, Zhifei.(2015).Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy.THERANOSTICS,5(10),1144-1153.
MLA Liu, Renfa,et al."Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy".THERANOSTICS 5.10(2015):1144-1153.
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