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Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy
Liu, Renfa1; Jing, Lijia1,3; Peng, Dong2; Li, Yong3; Tian, Jie2; Dai, Zhifei1
Source PublicationTHERANOSTICS
2015
Volume5Issue:10Pages:1144-1153
SubtypeArticle
AbstractThe integration of diagnostic and therapeutic functionalities into one nanoplatform shows great promise in cancer therapy. In this research, manganese (II) chelate functionalized copper sulfide nanoparticles were successfully prepared using a facile hydrothermal method. The obtained ultrasmall nanoparticles exhibit excellent photothermal effect and photoaoustic activity. Besides, the high loading content of Mn(II) chelates makes the nanoparticles attractive T1 contrast agent in magnetic resonance imaging (MRI). In vivo photoacoustic imaging (PAI) results showed that the nanoparticles could be efficiently accumulated in tumor site in 24 h after systematic administration, which was further validated by MRI tests. The subsequent photothermal therapy of cancer in vivo was achieved without inducing any observed side effects. Therefore, the copper sulfide nanoparticles functionalized with Mn(II) chelate hold great promise as a theranostic nanomedicine for MR/PA dual-modal imaging guided photothermal therapy of cancer.
KeywordCopper Sulfide Nanoparticles Nanotheranostic Agent Photoacoustic Imaging Magnatic Resonance Imaging Photothermal Therapy
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.7150/thno.11754
WOS KeywordMRI CONTRAST AGENTS ; IN-VIVO ; SYNERGISTIC THERAPY ; THERANOSTIC AGENT ; CANCER-CELLS ; ABLATION ; PLATFORM ; PROBE
Indexed BySCI
Language英语
WOS Research AreaResearch & Experimental Medicine
WOS SubjectMedicine, Research & Experimental
WOS IDWOS:000359472700008
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Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/8914
Collection中国科学院分子影像重点实验室
Corresponding AuthorDai, Zhifei
Affiliation1.Peking Univ, Dept Biomed Engn, Coll Engn, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
3.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China
Recommended Citation
GB/T 7714
Liu, Renfa,Jing, Lijia,Peng, Dong,et al. Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy[J]. THERANOSTICS,2015,5(10):1144-1153.
APA Liu, Renfa,Jing, Lijia,Peng, Dong,Li, Yong,Tian, Jie,&Dai, Zhifei.(2015).Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy.THERANOSTICS,5(10),1144-1153.
MLA Liu, Renfa,et al."Manganese (II) Chelate Functionalized Copper Sulfide Nanoparticles for Efficient Magnetic Resonance/Photoacoustic Dual-Modal Imaging Guided Photothermal Therapy".THERANOSTICS 5.10(2015):1144-1153.
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