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The neurobiological drive for overeating implicated in Prader-Willi syndrome
Zhang, Yi1,2,3; Wang, Jing1; Zhang, Guansheng1; Zhu, Qiang1; Cai, Weiwei1; Tian, Jie1,4; Zhang, Yi Edi2,3,5; Miller, Jennifer L.6; Wen, Xiaotong7; Ding, Mingzhou9; Gold, Mark S.2,3; Liu, Yijun2,3,8
Source PublicationBRAIN RESEARCH
AbstractPrader-Willi syndrome (PWS) is a genetic imprinting disorder characterized mainly by hyperphagia and early childhood obesity. Previous fMRI studies examined the activation of eating-related neural circuits in PWS patients with or without exposures to food cues and found an excessive eating motivation and a reduced inhibitory control of cognitive processing of food. However, the effective connectivity between various brain areas or neural circuitry critically implicated in both the biological and behavioral control of overeating in PWS is largely unexplored. The current study combined resting-state fMRI and Granger causality analysis (GCA) techniques to investigate interactive causal influences among key neural pathways underlying overeating in PWS. We first defined the regions of interest (ROIs) that demonstrated significant alterations of the baseline brain activity levels in children with PWS (n=21) as compared to that of their normal siblings controls (n=18), and then carried out GCA to characterize the region-to-region interactions among these ROIs. Our data revealed significantly enhanced causal influences from the amygdala to the hypothalamus and from both the medial prefrontal cortex and anterior cingulate cortex to the amygdala in patients with PWS (P<0.001). These alterations offer new explanations for hypothalamic regulation of homeostatic energy intake and impairment in inhibitory control circuit. The deficits in these dual aspects may jointly contribute to the extreme hyperphagia in PWS. This study provides both a new methodological and a neurobiological perspective to aid in a better understanding of neural mechanisms underlying obesity in the general public. This article is part of a Special Issue entitled 1618. (C) 2015 Elsevier B.V. All rights reserved.
KeywordPws Overeating Obesity Granger Causality Resting-state Fmri
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
Indexed BySCI
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000361162800006
Citation statistics
Cited Times:12[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorZhang, Yi
Affiliation1.Xidian Univ, Sch Life Sci & Technol, Xian 710071, Shaanxi, Peoples R China
2.Univ Florida, Dept Psychiat, Gainesville, FL 32610 USA
3.Univ Florida, McKnight Brain Inst, Gainesville, FL 32610 USA
4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
5.Malcom Randall Vet Affairs Med Ctr, Gainesville, FL 32608 USA
6.Univ Florida, Dept Pediat, Gainesville, FL 32610 USA
7.Remin Univ China, Dept Psychol, Beijing 100872, Peoples R China
8.Southwest Univ, Dept Psychol, Chongqing 400715, Peoples R China
9.Univ Florida, Dept Biomed Engn, Gainesville, FL 32610 USA
Recommended Citation
GB/T 7714
Zhang, Yi,Wang, Jing,Zhang, Guansheng,et al. The neurobiological drive for overeating implicated in Prader-Willi syndrome[J]. BRAIN RESEARCH,2015,1620(2015):72-80.
APA Zhang, Yi.,Wang, Jing.,Zhang, Guansheng.,Zhu, Qiang.,Cai, Weiwei.,...&Liu, Yijun.(2015).The neurobiological drive for overeating implicated in Prader-Willi syndrome.BRAIN RESEARCH,1620(2015),72-80.
MLA Zhang, Yi,et al."The neurobiological drive for overeating implicated in Prader-Willi syndrome".BRAIN RESEARCH 1620.2015(2015):72-80.
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