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Functional Connectivity Density in Congenitally and Late Blind Subjects
Qin, Wen1,2; Xuan, Yun3; Liu, Yong4,5; Jiang, Tianzi4,5; Yu, Chunshui1,2
2015-09-01
发表期刊CEREBRAL CORTEX
卷号25期号:9页码:2507-2516
文章类型Article
摘要Visual deprivation during different developmental periods leads to different structural and functional alterations in the brain; however, the effects of visual deprivation on the spontaneous functional organization of the brain remain largely unknown. In this study, we used voxel-based functional connectivity density (FCD) analyses to investigate the effects of visual deprivation during different developmental periods on the spontaneous functional organization of the brain. Compared with the sighted controls (SC), both the congenitally blind (CB) and the late blind (LB) exhibited decreased short-and long-range FCDs in the primary visual cortex (V1) and decreased long-range FCDs in the primary somatosensory and auditory cortices. Although both the CB and LB exhibited increased short-range FCD in the dorsal visual stream, the CB exhibited greater increases in the short-and long-range FCDs in the ventral visual stream and hippocampal complex compared with the LB. Moreover, the short-range FCD of the left V1 exhibited a significant positive correlation with the duration of blindness in the LB. Our findings suggest that visual deprivation before the developmental sensitive period can induce more extensive brain functional reorganization than does visual deprivation after the sensitive period, which may underlie an enhanced capacity for processing nonvisual information in the CB.
关键词Functional Connectivity Density Functional Magnetic Resonance Imaging Occipital Cortex Sensitive Period Visual Deprivation
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1093/cercor/bhu051
关键词[WOS]PRIMARY VISUAL-CORTEX ; DIFFUSION TENSOR TRACTOGRAPHY ; OCCIPITAL CORTEX ; WHITE-MATTER ; HUMAN BRAIN ; SIGHTED INDIVIDUALS ; CORTICAL ACTIVITY ; SENSITIVE PERIOD ; PARIETAL CORTEX ; HEAD MOTION
收录类别SCI
语种英语
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000361464000015
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/9008
专题脑网络组研究中心
作者单位1.Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin 300052, Peoples R China
2.Tianjin Med Univ Gen Hosp, Tianjin Key Lab Funct Imaging, Tianjin 300052, Peoples R China
3.Tianjin Med Univ Gen Hosp, Sch Basic Med Sci, Dept Anat, Tianjin 300052, Peoples R China
4.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China
5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
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GB/T 7714
Qin, Wen,Xuan, Yun,Liu, Yong,et al. Functional Connectivity Density in Congenitally and Late Blind Subjects[J]. CEREBRAL CORTEX,2015,25(9):2507-2516.
APA Qin, Wen,Xuan, Yun,Liu, Yong,Jiang, Tianzi,&Yu, Chunshui.(2015).Functional Connectivity Density in Congenitally and Late Blind Subjects.CEREBRAL CORTEX,25(9),2507-2516.
MLA Qin, Wen,et al."Functional Connectivity Density in Congenitally and Late Blind Subjects".CEREBRAL CORTEX 25.9(2015):2507-2516.
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