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Performance investigation of SP3 and diffusion approximation for three-dimensional whole-body optical imaging of small animals
Yang, Defu1; Chen, Xueli1; Cao, Xu1; Wang, Jing2; Liang, Jimin1; Tian, Jie1,3
2015-09-01
发表期刊MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
卷号53期号:9页码:805-814
文章类型Article
摘要The third-order simplified harmonic spherical approximation (SP3) and diffusion approximation (DA) equations have been widely used in the three-dimensional (3D) whole-body optical imaging of small animals. With different types of tissues, which were classified by the ratio of A mu (s)'/A mu (E), the two equations have their own application scopes. However, the classification criterion was blurring and unreasonable, and the scope has not been systematically investigated until now. In this study, a new criterion for classifying tissues was established based on the absolute value of absorption and reduced scattering coefficients. Using the newly defined classification criterion, the performance and applicability of the SP3 and DA equations were evaluated with a series of investigation experiments. Extensive investigation results showed that the SP3 equation exhibited a better performance and wider applicability than the DA one in most of the observed cases, especially in tissues of low-scattering-low-absorption and low-scattering-high-absorption range. For the case of tissues with the high-scattering-low-absorption properties, a similar performance was observed for both the SP3 and the DA equations, in which case the DA was the preferred option for 3D whole-body optical imaging. Results of this study would provide significant reference for the study of hybrid light transport models.
关键词Tissue Classification Criterion Performance Investigation Third-order Simplified Harmonic Spherical Approximation Diffusion Approximation Three-dimensional Optical Imaging
WOS标题词Science & Technology ; Technology ; Life Sciences & Biomedicine
DOI10.1007/s11517-015-1293-8
关键词[WOS]SIMPLIFIED SPHERICAL-HARMONICS ; LOW-SCATTERING ; BIOLUMINESCENCE TOMOGRAPHY ; PHOTON MIGRATION ; LIGHT TRANSPORT ; TURBID MEDIA ; REGIONS ; TISSUE ; RECONSTRUCTION ; PROPAGATION
收录类别SCI
语种英语
WOS研究方向Computer Science ; Engineering ; Mathematical & Computational Biology ; Medical Informatics
WOS类目Computer Science, Interdisciplinary Applications ; Engineering, Biomedical ; Mathematical & Computational Biology ; Medical Informatics
WOS记录号WOS:000361491900004
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/9015
专题中国科学院分子影像重点实验室
通讯作者Chen, Xueli
作者单位1.Xidian Univ, Sch Life Sci & Technol, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Xian 710071, Shaanxi, Peoples R China
2.Fourth Mil Med Univ, Xijing Hosp, Dept Nucl Med, Xian 710032, Shaanxi, Peoples R China
3.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
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Yang, Defu,Chen, Xueli,Cao, Xu,et al. Performance investigation of SP3 and diffusion approximation for three-dimensional whole-body optical imaging of small animals[J]. MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING,2015,53(9):805-814.
APA Yang, Defu,Chen, Xueli,Cao, Xu,Wang, Jing,Liang, Jimin,&Tian, Jie.(2015).Performance investigation of SP3 and diffusion approximation for three-dimensional whole-body optical imaging of small animals.MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING,53(9),805-814.
MLA Yang, Defu,et al."Performance investigation of SP3 and diffusion approximation for three-dimensional whole-body optical imaging of small animals".MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING 53.9(2015):805-814.
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