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Discriminative analysis of brain function at resting-state for attention-deficit/hyperactivity disorder
Zhu, CZ; Zang, YF; Liang, M; Tian, LX; He, Y; Li, XB; Sui, MQ; Wang, YF; Jiang, TZ; Duncan, JS; Gerig, G
2005
发表期刊MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2005, PT 2
卷号3750页码:468-475
文章类型Article
摘要In this work, a discriminative model of attention deficit hyperactivity disorder (ADHD) is presented on the basis of multivariate pattern classification and functional magnetic resonance imaging (fMRI). This model consists of two parts, a classifier and an intuitive representation of discriminative pattern of brain function between patients and normal controls. Regional homogeneity (ReHo), a measure of brain function at resting-state, is used here as a feature of classification. Fisher discriminative analysis (FDA) is performed on the features of training samples and a linear classifier is generated. Our initial experimental results show a successful classification rate of 85%, using leave-one-out cross validation. The classifier is also compared with linear support vector machine (SVM) and Batch Perceptron. Our classifier outperforms the alternatives significantly. Fisher brain, the optimal projective-direction vector in FDA, is used to represent the discriminative pattern. Some abnormal brain regions identified by Fisher brain, like prefrontal cortex and anterior cingulate cortex, are well consistent with that reported in neuroimaging studies on ADHD. Moreover, some less reported but highly discriminative regions are also identified. We conclude that the discriminative model has potential ability to improve current diagnosis and treatment evaluation of ADHD.
WOS标题词Science & Technology ; Technology ; Life Sciences & Biomedicine
关键词[WOS]DEFICIT HYPERACTIVITY DISORDER ; ALZHEIMERS-DISEASE ; MAGNETIC-RESONANCE ; CLASSIFICATION ; CONNECTIVITY ; MRI ; FLUCTUATIONS ; CEREBELLUM ; IMAGES ; CORTEX
收录类别ISTP ; SCI
语种英语
WOS研究方向Computer Science ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Computer Science, Information Systems ; Computer Science, Theory & Methods ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000233356900058
引用统计
被引频次:54[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/9069
专题09年以前成果
作者单位1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100864, Peoples R China
2.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhu, CZ,Zang, YF,Liang, M,et al. Discriminative analysis of brain function at resting-state for attention-deficit/hyperactivity disorder[J]. MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2005, PT 2,2005,3750:468-475.
APA Zhu, CZ.,Zang, YF.,Liang, M.,Tian, LX.,He, Y.,...&Gerig, G.(2005).Discriminative analysis of brain function at resting-state for attention-deficit/hyperactivity disorder.MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2005, PT 2,3750,468-475.
MLA Zhu, CZ,et al."Discriminative analysis of brain function at resting-state for attention-deficit/hyperactivity disorder".MEDICAL IMAGE COMPUTING AND COMPUTER-ASSISTED INTERVENTION - MICCAI 2005, PT 2 3750(2005):468-475.
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