Classification of real and pseudo microRNA precursors using local structure-sequence features and support vector machine

CASIA OpenIR > 09年以前成果

	Classification of real and pseudo microRNA precursors using local structure-sequence features and support vector machine
	Xue, CH ; Li, F ; He, T ; Liu, GP ; Li, YD; Zhang, XG
发表期刊	BMC BIOINFORMATICS
	2005-12-29
卷号	6
文章类型	Article
摘要	Background: MicroRNAs (miRNAs) are a group of short (similar to 22 nt) non-coding RNAs that play important regulatory roles. MiRNA precursors (pre-miRNAs) are characterized by their hairpin structures. However, a large amount of similar hairpins can be folded in many genomes. Almost all current methods for computational prediction of miRNAs use comparative genomic approaches to identify putative pre-miRNAs from candidate hairpins. Ab initio method for distinguishing pre-miRNAs from sequence segments with pre-miRNA-like hairpin structures is lacking. Being able to classify real vs. pseudo pre-miRNAs is important both for understanding of the nature of miRNAs and for developing ab initio prediction methods that can discovery new miRNAs without known homology.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	COMPUTATIONAL IDENTIFICATION ; PLANT MICRORNAS ; NUCLEAR EXPORT ; RNASE-III ; GENES ; ALIGNMENT ; KERNELS
收录类别	SCI
语种	英语
WOS研究方向	Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Mathematical & Computational Biology
WOS类目	Biochemical Research Methods ; Biotechnology & Applied Microbiology ; Mathematical & Computational Biology
WOS记录号	WOS:000235080700001
引用统计	被引频次：340[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/9113
专题	09年以前成果
作者单位	1.Tsing Hua Univ, Dept Automat, MOE Key Lab Bioinformat, Beijing 100084, Peoples R China 2.Chinese Acad Sci, Inst Automat, Lab Complex Syst & Intelligence Sci, Beijing 100080, Peoples R China 3.Univ Glamorgan, Sch Elect, Pontypridd CF37 1DL, M Glam, Wales
推荐引用方式 GB/T 7714	Xue, CH,Li, F,He, T,et al. Classification of real and pseudo microRNA precursors using local structure-sequence features and support vector machine[J]. BMC BIOINFORMATICS,2005,6.
APA	Xue, CH,Li, F,He, T,Liu, GP,Li, YD,&Zhang, XG.(2005).Classification of real and pseudo microRNA precursors using local structure-sequence features and support vector machine.BMC BIOINFORMATICS,6.
MLA	Xue, CH,et al."Classification of real and pseudo microRNA precursors using local structure-sequence features and support vector machine".BMC BIOINFORMATICS 6(2005).