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Classification of real and pseudo microRNA precursors using local structure-sequence features and support vector machine
Xue, CH; Li, F; He, T; Liu, GP; Li, YD; Zhang, XG
Source PublicationBMC BIOINFORMATICS
2005-12-29
Volume6
SubtypeArticle
AbstractBackground: MicroRNAs (miRNAs) are a group of short (similar to 22 nt) non-coding RNAs that play important regulatory roles. MiRNA precursors (pre-miRNAs) are characterized by their hairpin structures. However, a large amount of similar hairpins can be folded in many genomes. Almost all current methods for computational prediction of miRNAs use comparative genomic approaches to identify putative pre-miRNAs from candidate hairpins. Ab initio method for distinguishing pre-miRNAs from sequence segments with pre-miRNA-like hairpin structures is lacking. Being able to classify real vs. pseudo pre-miRNAs is important both for understanding of the nature of miRNAs and for developing ab initio prediction methods that can discovery new miRNAs without known homology.
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordCOMPUTATIONAL IDENTIFICATION ; PLANT MICRORNAS ; NUCLEAR EXPORT ; RNASE-III ; GENES ; ALIGNMENT ; KERNELS
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Mathematical & Computational Biology
WOS SubjectBiochemical Research Methods ; Biotechnology & Applied Microbiology ; Mathematical & Computational Biology
WOS IDWOS:000235080700001
Citation statistics
Cited Times:265[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/9113
Collection09年以前成果
Affiliation1.Tsing Hua Univ, Dept Automat, MOE Key Lab Bioinformat, Beijing 100084, Peoples R China
2.Chinese Acad Sci, Inst Automat, Lab Complex Syst & Intelligence Sci, Beijing 100080, Peoples R China
3.Univ Glamorgan, Sch Elect, Pontypridd CF37 1DL, M Glam, Wales
Recommended Citation
GB/T 7714
Xue, CH,Li, F,He, T,et al. Classification of real and pseudo microRNA precursors using local structure-sequence features and support vector machine[J]. BMC BIOINFORMATICS,2005,6.
APA Xue, CH,Li, F,He, T,Liu, GP,Li, YD,&Zhang, XG.(2005).Classification of real and pseudo microRNA precursors using local structure-sequence features and support vector machine.BMC BIOINFORMATICS,6.
MLA Xue, CH,et al."Classification of real and pseudo microRNA precursors using local structure-sequence features and support vector machine".BMC BIOINFORMATICS 6(2005).
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