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Phylogenetic analysis of Na+/K+ ATPase: Insight into the mechanism for the genesis of multi-isoforms of protein complex
Ma, F; Huang, HF; Lin, LP; Xue, CH; Li-Ling, J; Chen, LM; Wang, YQ; Li, QW; Li, YD
2005-09-01
发表期刊JOURNAL OF BIOLOGICAL SYSTEMS
卷号13期号:3页码:299-312
文章类型Article
摘要One most notable trend during the evolution is the substantial expansion of genomes along with dramatic expansion of protein diversity. It has been discovered that, whilst in prokaryotes subunits of many proteinases axe encoded by single genes, these are mostly encoded by multi-genes in eukaryotes. To understand the mechanism for the genesis of multi-isoforms of protein complex, we have analyzed amino acid sequences of Na+/K+ ATPase from various species ranging from archaea to vertebrates. Phylogenetic relationship between the selected species was considered from the perspective of important functional domains of Na+/K+ ATPase including cation ATPase N termination, E1-E2 ATPase, hydrolase, and cation ATPase C termination of the a subunit, Na+/K+ ATPase of the beta subunit, and ATP1G1_PLM_MAT8 of the gamma subunit. Coincident trees, obtained through comparison of aforementioned domains of the alpha and beta subunits, were used to examine the evolutionary divergence. By conservational and phylogenetic analyses, evolution of the Na+/K+ ATPase was outlined. Evidence was also found that essential domains of the Na+/K+ ATPase have been conserved during the evolution. These investigations seem to imply that various isoforms of alpha and beta subunits of vertebral Na+/K+ ATPases have evolved from single ancestral alpha and beta subunit genes through duplication events. In addition, our results seem to suggest a third fate for duplicated genes, e.g. the duplicate may have the same function as their ancestor gene. The results may also provide important clues to the underlying mechanisms of genesis of Na+/K+ ATPase multi-isoforms.
关键词na+/k+ Atpase Phylogenetic Analysis Functional Domain Evolution Gene Duplication
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]P-TYPE ATPASES ; EVOLUTION ; ORGANIZATION ; NA,K-ATPASE
收录类别SCI
语种英语
WOS研究方向Life Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology
WOS类目Biology ; Mathematical & Computational Biology
WOS记录号WOS:000232283500006
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/9169
专题09年以前成果
作者单位1.Liaoning Normal Univ, Coll Life Sci, Lab Comparat Genome & Bioinformat, Dalian 116029, Peoples R China
2.Xiamen Univ, Sch Life Sci, Xiamen 361005, Peoples R China
3.Tsinghua Univ, Dept Automat, MOE Key Lab Bioinformat, Beijing 100084, Peoples R China
4.Chinese Acad Sci, Inst Automat, Lab Complex Syst & Intelligence Sci, Beijing 100080, Peoples R China
5.China Med Univ, Dept Med Genet, Shenyang 110001, Peoples R China
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Ma, F,Huang, HF,Lin, LP,et al. Phylogenetic analysis of Na+/K+ ATPase: Insight into the mechanism for the genesis of multi-isoforms of protein complex[J]. JOURNAL OF BIOLOGICAL SYSTEMS,2005,13(3):299-312.
APA Ma, F.,Huang, HF.,Lin, LP.,Xue, CH.,Li-Ling, J.,...&Li, YD.(2005).Phylogenetic analysis of Na+/K+ ATPase: Insight into the mechanism for the genesis of multi-isoforms of protein complex.JOURNAL OF BIOLOGICAL SYSTEMS,13(3),299-312.
MLA Ma, F,et al."Phylogenetic analysis of Na+/K+ ATPase: Insight into the mechanism for the genesis of multi-isoforms of protein complex".JOURNAL OF BIOLOGICAL SYSTEMS 13.3(2005):299-312.
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