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Exploring candidate genes for human brain diseases from a brain-specific gene network
Liu, Bing; Jiang, Tianzi; Ma, Songde; Zhao, Huizhi; Li, Jun; Jiang, Xingpeng; Zhang, Jing
2006-11-03
发表期刊BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷号349期号:4页码:1308-1314
文章类型Article
摘要It is believed that large numbers of genes are involved in common human brain diseases. Here, we propose a novel computational strategy for simultaneously identifying multiple candidate genes for genetic human brain diseases from a brain-specific gene network-level perspective. By integrating diverse genomic and proteomic datasets based on Bayesian statistical model, we built a large-scale human brain-specific gene network. Based on this network and minor prior knowledge of a specific brain disease, we can effectively identify multiple candidate genes for this disease. When four known Alzheimer's disease genes were used as the prior knowledge, among the top 46 high-scoring genes that we have found, 37 were previously reported to be associated with Alzheimer's disease. And the higher score a gene has, the more likely this gene is a disease-related one. The results suggest that the proposed method is effective, convenient, and applicable in the future genetic studies. (c) 2006 Elsevier Inc. All rights reserved.
关键词Bayesian Statistical Model Brain-specific Gene Network Subnetwork Candidate Genes
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]PROTEIN-PROTEIN INTERACTIONS ; ALZHEIMERS-DISEASE ; ASSOCIATION ; INTERACTOME ; MAP
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
WOS类目Biochemistry & Molecular Biology ; Biophysics
WOS记录号WOS:000241064800019
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被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/9242
专题09年以前成果
作者单位Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China
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GB/T 7714
Liu, Bing,Jiang, Tianzi,Ma, Songde,et al. Exploring candidate genes for human brain diseases from a brain-specific gene network[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,349(4):1308-1314.
APA Liu, Bing.,Jiang, Tianzi.,Ma, Songde.,Zhao, Huizhi.,Li, Jun.,...&Zhang, Jing.(2006).Exploring candidate genes for human brain diseases from a brain-specific gene network.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,349(4),1308-1314.
MLA Liu, Bing,et al."Exploring candidate genes for human brain diseases from a brain-specific gene network".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 349.4(2006):1308-1314.
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