Changes in hippocampal connectivity in the early stages of Alzheimer's disease: Evidence from resting state fMRI

CASIA OpenIR > 09年以前成果

	Changes in hippocampal connectivity in the early stages of Alzheimer's disease: Evidence from resting state fMRI
	Wang, Liang ; Zang, Yufeng ; He, Yong ; Liang, Meng ; Zhang, Xinqing ; Tian, Lixia ; Wu, Tao ; Jiang, Tianzi; Li, Kuncheng
发表期刊	NEUROIMAGE
	2006-06-01
卷号	31 期号:2 页码:496-504
文章类型	Article
摘要	A selective distribution of Alzheimer's disease (AD) pathological lesions in specific cortical layers isolates the hippocampus from the rest of the brain. However, functional connectivity between the hippocampus and other brain regions remains unclear in AD. Here, we employ a resting state functional NM (fMRI) to examine changes in hippocampal connectivity comparing 13 patients with mild AD versus 13 healthy age-matched controls. Hippocampal connectivity was investigated by examination of the correlation between low frequency fMRI signal fluctuations in the hippocampus and those in all other brain regions. We found that functional connectivity between the right hippocampus and a set of regions was disrupted in AD; these regions are: medial prefrontal cortex (MPFC), ventral anterior cingulate cortex (vACC), right inferotemporal cortex, right cuneus extending into precuneus, left cuneus, right superior and middle temporal gyros and posterior cingulate cortex (PCC). We also found increased functional connectivity between the left hippocampus and the right lateral prefrontal cortex in AD. In addition, rightward asymmetry of hippocampal connectivity observed in elderly controls was diminished in AD patients. The disrupted hippocampal connectivity to the MPFC, vACC and PCC provides further support for decreased activity in "default mode network" previously shown in AD. The decreased connectivity between the hippocampus and the visual cortices might indicate reduced integrity of hippocampus-related cortical networks in AD. Moreover, these findings suggest that resting-state fMRI might be an appropriate approach for studying pathophysiological changes in early AD. (c) 2005 Elsevier Inc. All rights reserved.
关键词	Alzheimer's Disease Hippocampus Functional Mri Functional Connectivity Resting State
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	MILD COGNITIVE IMPAIRMENT ; APOLIPOPROTEIN-E GENOTYPE ; ECHO-PLANAR MRI ; FUNCTIONAL CONNECTIVITY ; DEFAULT-MODE ; HUMAN BRAIN ; NETWORK ANALYSIS ; CEREBRAL-CORTEX ; MOTOR CORTEX ; MEMORY
收录类别	SCI
语种	英语
WOS研究方向	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000238232100004
引用统计	被引频次：627[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/9358
专题	09年以前成果
作者单位	1.Capital Univ Med Sci, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China 2.Capital Univ Med Sci, Xuanwu Hosp, Dept Neurol, Beijing 100053, Peoples R China 3.Beijing Inst Geriatr, Beijing 100053, Peoples R China 4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Wang, Liang,Zang, Yufeng,He, Yong,et al. Changes in hippocampal connectivity in the early stages of Alzheimer's disease: Evidence from resting state fMRI[J]. NEUROIMAGE,2006,31(2):496-504.
APA	Wang, Liang.,Zang, Yufeng.,He, Yong.,Liang, Meng.,Zhang, Xinqing.,...&Li, Kuncheng.(2006).Changes in hippocampal connectivity in the early stages of Alzheimer's disease: Evidence from resting state fMRI.NEUROIMAGE,31(2),496-504.
MLA	Wang, Liang,et al."Changes in hippocampal connectivity in the early stages of Alzheimer's disease: Evidence from resting state fMRI".NEUROIMAGE 31.2(2006):496-504.