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Quantitative analysis along the pyramidal tract by length-normalized parameterization based on diffusion tensor tractography: Application to patients with relapsing neuromyelitis optica
Lin, Fuchun; Yu, Chunshui; Jiang, Tianzi; Li, Kuncheng; Li, Xiaobo; Qin, Wen; Sun, Hong; Chan, Piu
2006-10-15
发表期刊NEUROIMAGE
卷号33期号:1页码:154-160
文章类型Article
摘要In this study, we introduced a length-normalized parameterization method to establish anatomical correspondence of white matter fiber tracts across subjects and applied this method to investigate the presence of abnormal diffusion along the pyramidal tract (PYT) of relapsing neuromyelitis optica (RNMO) patients without visible brain lesions. In this approach, the part of the PYT between the lowest slice of the cerebral peduncle and the uppermost slice of the lateral ventricle was reconstructed to establish the anatomical correspondence across subjects using diffusion tensor tractography. Then it was parameterized by normalizing its length and dividing equally the normalized length into a certain number of segments, so that the comparability of each segment across subjects along the PYT was established. Tract-specific diffusion indices, including directionally averaged diffusivity (D-av), fractional anisotropy (FA), primary diffusivity (lambda(1)) and transverse diffusivity (lambda(23)), were obtained from each segment. Thus, the distribution maps of these indices along the PYT were obtained. The distribution maps of D-av, FA, and lambda(23) of RNMO patients were significantly different from those of healthy controls, especially in the lower part of the PYT. The differences may be caused by secondary degeneration to lesions in the spinal cord. In conclusion, a length-normalized parameterization method is proposed to establish anatomical correspondence for the PYT. Compared with existed methods, a major merit of our method is to provide comparability across subjects along the PYT on the basis of diffusion tensor tractography and to make it possible for the quantitative analysis along the fiber tract. This method can also be used to quantitatively analyze other white matter fiber tracts between two definite anatomic landmarks in many neurological or psychiatric diseases. (c) 2006 Elsevier Inc. All rights reserved.
关键词Tractography Length-normalized Parameterization Diffusion Indices Pyramidal Tract Relapsing Neuromyelitis Optica
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]AMYOTROPHIC-LATERAL-SCLEROSIS ; WHITE-MATTER TRACTS ; DT-MRI DATA ; WALLERIAN DEGENERATION ; CORTICOSPINAL TRACT ; MULTIPLE-SCLEROSIS ; WATER DIFFUSION ; FIBER TRACTOGRAPHY ; HUMAN BRAIN ; TRACKING
收录类别SCI
语种英语
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000241209800017
引用统计
被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/9377
专题09年以前成果
作者单位1.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100080, Peoples R China
2.Capital Univ Med Sci, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China
3.Capital Univ Med Sci, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China
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GB/T 7714
Lin, Fuchun,Yu, Chunshui,Jiang, Tianzi,et al. Quantitative analysis along the pyramidal tract by length-normalized parameterization based on diffusion tensor tractography: Application to patients with relapsing neuromyelitis optica[J]. NEUROIMAGE,2006,33(1):154-160.
APA Lin, Fuchun.,Yu, Chunshui.,Jiang, Tianzi.,Li, Kuncheng.,Li, Xiaobo.,...&Chan, Piu.(2006).Quantitative analysis along the pyramidal tract by length-normalized parameterization based on diffusion tensor tractography: Application to patients with relapsing neuromyelitis optica.NEUROIMAGE,33(1),154-160.
MLA Lin, Fuchun,et al."Quantitative analysis along the pyramidal tract by length-normalized parameterization based on diffusion tensor tractography: Application to patients with relapsing neuromyelitis optica".NEUROIMAGE 33.1(2006):154-160.
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