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Quantitative analysis along the pyramidal tract by length-normalized parameterization based on diffusion tensor tractography: Application to patients with relapsing neuromyelitis optica
Lin, Fuchun; Yu, Chunshui; Jiang, Tianzi; Li, Kuncheng; Li, Xiaobo; Qin, Wen; Sun, Hong; Chan, Piu
Source PublicationNEUROIMAGE
2006-10-15
Volume33Issue:1Pages:154-160
SubtypeArticle
AbstractIn this study, we introduced a length-normalized parameterization method to establish anatomical correspondence of white matter fiber tracts across subjects and applied this method to investigate the presence of abnormal diffusion along the pyramidal tract (PYT) of relapsing neuromyelitis optica (RNMO) patients without visible brain lesions. In this approach, the part of the PYT between the lowest slice of the cerebral peduncle and the uppermost slice of the lateral ventricle was reconstructed to establish the anatomical correspondence across subjects using diffusion tensor tractography. Then it was parameterized by normalizing its length and dividing equally the normalized length into a certain number of segments, so that the comparability of each segment across subjects along the PYT was established. Tract-specific diffusion indices, including directionally averaged diffusivity (D-av), fractional anisotropy (FA), primary diffusivity (lambda(1)) and transverse diffusivity (lambda(23)), were obtained from each segment. Thus, the distribution maps of these indices along the PYT were obtained. The distribution maps of D-av, FA, and lambda(23) of RNMO patients were significantly different from those of healthy controls, especially in the lower part of the PYT. The differences may be caused by secondary degeneration to lesions in the spinal cord. In conclusion, a length-normalized parameterization method is proposed to establish anatomical correspondence for the PYT. Compared with existed methods, a major merit of our method is to provide comparability across subjects along the PYT on the basis of diffusion tensor tractography and to make it possible for the quantitative analysis along the fiber tract. This method can also be used to quantitatively analyze other white matter fiber tracts between two definite anatomic landmarks in many neurological or psychiatric diseases. (c) 2006 Elsevier Inc. All rights reserved.
KeywordTractography Length-normalized Parameterization Diffusion Indices Pyramidal Tract Relapsing Neuromyelitis Optica
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordAMYOTROPHIC-LATERAL-SCLEROSIS ; WHITE-MATTER TRACTS ; DT-MRI DATA ; WALLERIAN DEGENERATION ; CORTICOSPINAL TRACT ; MULTIPLE-SCLEROSIS ; WATER DIFFUSION ; FIBER TRACTOGRAPHY ; HUMAN BRAIN ; TRACKING
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000241209800017
Citation statistics
Cited Times:35[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/9377
Collection09年以前成果
Affiliation1.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100080, Peoples R China
2.Capital Univ Med Sci, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China
3.Capital Univ Med Sci, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Lin, Fuchun,Yu, Chunshui,Jiang, Tianzi,et al. Quantitative analysis along the pyramidal tract by length-normalized parameterization based on diffusion tensor tractography: Application to patients with relapsing neuromyelitis optica[J]. NEUROIMAGE,2006,33(1):154-160.
APA Lin, Fuchun.,Yu, Chunshui.,Jiang, Tianzi.,Li, Kuncheng.,Li, Xiaobo.,...&Chan, Piu.(2006).Quantitative analysis along the pyramidal tract by length-normalized parameterization based on diffusion tensor tractography: Application to patients with relapsing neuromyelitis optica.NEUROIMAGE,33(1),154-160.
MLA Lin, Fuchun,et al."Quantitative analysis along the pyramidal tract by length-normalized parameterization based on diffusion tensor tractography: Application to patients with relapsing neuromyelitis optica".NEUROIMAGE 33.1(2006):154-160.
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