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Functional dysconnectivity of the dorsolateral prefrontal cortex in first-episode schizophrenia using resting-state fMRI
Zhou, Yuan; Liang, Meng; Jiang, Tianzi; Tian, Lixia; Liu, Yong; Liu, Zhening; Liu, Haihong; Kuang, Fan
2007-05-07
发表期刊NEUROSCIENCE LETTERS
卷号417期号:3页码:297-302
文章类型Article
摘要The known regional abnormality of the dorsolateral prefrontal cortex (DLPFC) and its role in various neural circuits in schizophrenia has given prominence to its importance in studies on the dysconnection associated with schizophrenia. Abnormal functional connectivities of the DLPFC have been found during various goal-directed tasks; however, the occurrence of the abnormality during rest in patients with schizophrenia has rarely been reported. In the present study, we selected bilateral Brodmann's area 46 as region of interest and analyzed the differences in the DLPFC functional connectivity pattern between 17 patients with first-episode schizophrenia (FES) and 17 matched controls using resting-state fmRI. We found that the bilateral DLPFC showed reduced functional connectivities to the parietal lobe, posterior cingulate cortex, thalamus and striatum in FES patients. We also found enhanced functional connectivity between the left DLPFC and the left mid-posterior temporal lobe and the paralimbic regions in FES patients. Our results suggest that functional dysconnectivity associated with the DLPFC exists in schizophrenia during rest. This may be partially related to disturbance in the intrinsic brain activity. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
关键词Schizophrenia Fmri Dorsolateral Prefrontal Cortex Connectivity Resting State
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]LOW-FREQUENCY ; DEFAULT MODE ; HUMAN BRAIN ; CONNECTIVITY ; DISCONNECTIVITY ; FLUCTUATIONS ; HYPOTHESIS ; HYPOFRONTALITY ; NETWORK
收录类别SCI
语种英语
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000246666500016
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/9408
专题09年以前成果
作者单位1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China
2.Cent S Univ, Xiangya Hosp 2, Inst Mental Hlth, Changsha 410011, Hunan, Peoples R China
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Zhou, Yuan,Liang, Meng,Jiang, Tianzi,et al. Functional dysconnectivity of the dorsolateral prefrontal cortex in first-episode schizophrenia using resting-state fMRI[J]. NEUROSCIENCE LETTERS,2007,417(3):297-302.
APA Zhou, Yuan.,Liang, Meng.,Jiang, Tianzi.,Tian, Lixia.,Liu, Yong.,...&Kuang, Fan.(2007).Functional dysconnectivity of the dorsolateral prefrontal cortex in first-episode schizophrenia using resting-state fMRI.NEUROSCIENCE LETTERS,417(3),297-302.
MLA Zhou, Yuan,et al."Functional dysconnectivity of the dorsolateral prefrontal cortex in first-episode schizophrenia using resting-state fMRI".NEUROSCIENCE LETTERS 417.3(2007):297-302.
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