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Regional coherence changes in the early stages of Alzheimer's disease: A combined structural and resting-state functional MRI study
He, Yong; Wang, Liang; Zang, Yufeng; Tian, Lixia; Zhang, Xinqing; Li, Kuncheng; Jiang, Tianzi
Source PublicationNEUROIMAGE
2007-04-01
Volume35Issue:2Pages:488-500
SubtypeArticle
AbstractRecent functional imaging studies have indicated that the pathophysiology of Alzheimer's disease (AD) can be associated with the changes in spontaneous low-frequency (< 0.08 Hz) blood oxygenation level-dependent fluctuations (LFBF) measured during a resting state. The purpose of this study was to examine regional LFBF coherence patterns in early AD and the impact of regional brain atrophy on the functional results. Both structural MRI and resting-state functional MRI scans were collected from 14 AD subjects and 14 age-matched normal controls. We found significant regional coherence decreases in the posterior cingulate cortex/precuneus (PCC/PCu) in the AD patients when compared with the normal controls. Moreover, the decrease in the PCC/PCu coherence was correlated with the disease progression measured by the Mini-Mental State Exam scores. The changes in LFBF in the PCC/PCu may be related to the resting hypometabolism in this region commonly detected in previous positron emission tomography studies of early AD. When the regional PCC/ PCu atrophy was controlled, these results still remained significant but with a decrease in the statistical power, suggesting that the LFBF results are at least partly explained by the regional atrophy. In addition, we also found increased LFBF coherence in the bilateral cuneus, right lingual gyrus and left fusiform gyrus in the AD patients. These regions are consistent with previous findings of AD-related increased activation during cognitive tasks explained in terms of a compensatory- recruitment hypothesis. Finally, our study indicated that regional brain atrophy could be an important consideration in functional imaging studies of neurodegenerative diseases. (c) 2006 Elsevier Inc. All rights reserved.
KeywordAlzheimer's Disease Default Mode Functional Connectivity Morphometry Neuroimaging Posterior Cingulate Cortex Resting State Spectrum
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordVOXEL-BASED MORPHOMETRY ; GRAY-MATTER LOSS ; LEVEL-DEPENDENT FLUCTUATIONS ; MILD COGNITIVE IMPAIRMENT ; MAGNETIC-RESONANCE IMAGES ; EPISODIC MEMORY RETRIEVAL ; DEFAULT-MODE ; HUMAN BRAIN ; HIPPOCAMPAL CONNECTIVITY ; CEREBRAL ATROPHY
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000245293100005
Citation statistics
Cited Times:361[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/9413
Collection09年以前成果
Affiliation1.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100080, Peoples R China
2.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China
3.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
4.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing 100053, Peoples R China
Recommended Citation
GB/T 7714
He, Yong,Wang, Liang,Zang, Yufeng,et al. Regional coherence changes in the early stages of Alzheimer's disease: A combined structural and resting-state functional MRI study[J]. NEUROIMAGE,2007,35(2):488-500.
APA He, Yong.,Wang, Liang.,Zang, Yufeng.,Tian, Lixia.,Zhang, Xinqing.,...&Jiang, Tianzi.(2007).Regional coherence changes in the early stages of Alzheimer's disease: A combined structural and resting-state functional MRI study.NEUROIMAGE,35(2),488-500.
MLA He, Yong,et al."Regional coherence changes in the early stages of Alzheimer's disease: A combined structural and resting-state functional MRI study".NEUROIMAGE 35.2(2007):488-500.
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