Regional coherence changes in the early stages of Alzheimer's disease: A combined structural and resting-state functional MRI study

CASIA OpenIR > 09年以前成果

	Regional coherence changes in the early stages of Alzheimer's disease: A combined structural and resting-state functional MRI study
	He, Yong ; Wang, Liang ; Zang, Yufeng ; Tian, Lixia ; Zhang, Xinqing ; Li, Kuncheng ; Jiang, Tianzi
发表期刊	NEUROIMAGE
	2007-04-01
卷号	35 期号:2 页码:488-500
文章类型	Article
摘要	Recent functional imaging studies have indicated that the pathophysiology of Alzheimer's disease (AD) can be associated with the changes in spontaneous low-frequency (< 0.08 Hz) blood oxygenation level-dependent fluctuations (LFBF) measured during a resting state. The purpose of this study was to examine regional LFBF coherence patterns in early AD and the impact of regional brain atrophy on the functional results. Both structural MRI and resting-state functional MRI scans were collected from 14 AD subjects and 14 age-matched normal controls. We found significant regional coherence decreases in the posterior cingulate cortex/precuneus (PCC/PCu) in the AD patients when compared with the normal controls. Moreover, the decrease in the PCC/PCu coherence was correlated with the disease progression measured by the Mini-Mental State Exam scores. The changes in LFBF in the PCC/PCu may be related to the resting hypometabolism in this region commonly detected in previous positron emission tomography studies of early AD. When the regional PCC/ PCu atrophy was controlled, these results still remained significant but with a decrease in the statistical power, suggesting that the LFBF results are at least partly explained by the regional atrophy. In addition, we also found increased LFBF coherence in the bilateral cuneus, right lingual gyrus and left fusiform gyrus in the AD patients. These regions are consistent with previous findings of AD-related increased activation during cognitive tasks explained in terms of a compensatory- recruitment hypothesis. Finally, our study indicated that regional brain atrophy could be an important consideration in functional imaging studies of neurodegenerative diseases. (c) 2006 Elsevier Inc. All rights reserved.
关键词	Alzheimer's Disease Default Mode Functional Connectivity Morphometry Neuroimaging Posterior Cingulate Cortex Resting State Spectrum
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	VOXEL-BASED MORPHOMETRY ; GRAY-MATTER LOSS ; LEVEL-DEPENDENT FLUCTUATIONS ; MILD COGNITIVE IMPAIRMENT ; MAGNETIC-RESONANCE IMAGES ; EPISODIC MEMORY RETRIEVAL ; DEFAULT-MODE ; HUMAN BRAIN ; HIPPOCAMPAL CONNECTIVITY ; CEREBRAL ATROPHY
收录类别	SCI
语种	英语
WOS研究方向	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000245293100005
引用统计	被引频次：465[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/9413
专题	09年以前成果
作者单位	1.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100080, Peoples R China 2.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China 3.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China 4.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing 100053, Peoples R China
推荐引用方式 GB/T 7714	He, Yong,Wang, Liang,Zang, Yufeng,et al. Regional coherence changes in the early stages of Alzheimer's disease: A combined structural and resting-state functional MRI study[J]. NEUROIMAGE,2007,35(2):488-500.
APA	He, Yong.,Wang, Liang.,Zang, Yufeng.,Tian, Lixia.,Zhang, Xinqing.,...&Jiang, Tianzi.(2007).Regional coherence changes in the early stages of Alzheimer's disease: A combined structural and resting-state functional MRI study.NEUROIMAGE,35(2),488-500.
MLA	He, Yong,et al."Regional coherence changes in the early stages of Alzheimer's disease: A combined structural and resting-state functional MRI study".NEUROIMAGE 35.2(2007):488-500.