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Alignment of two-dimensional electrophoresis gels
Shi, Guihua; Jiang, Tianzi; Zhu, Wanlin; Liu, Bing; Zhao, Huizhi
Source PublicationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2007-06-01
Volume357Issue:2Pages:427-432
SubtypeArticle
AbstractTwo-dimensional electrophoresis is a major separating technique for proteins in proteomics. Alignment of gel images is critical for intra-laboratory or even more difficult inter-laboratory gel comparisons. In the paper, we propose a novel iterative closest point (ICP) method for 2D-gel electrophoresis image alignment. The paper seeks to introduce an information theoretic measure as one part of distance metric to gel image alignment. We combine intensity information of spots with geometric information of landmarks by applying information potential idea. The proposed method has been applied to both synthetic and real gel images accessible in public 2D-electrophoresis gel protein databases. The high accuracy and robustness of the algorithm indicate that it is promising for gel image alignment. (c) 2007 Elsevier Inc. All rights reserved.
Keyword2d-gel Electrophoresis Image Image Alignment Icp Algorithm Informational Potential
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordELASTIC REGISTRATION ; IMAGE REGISTRATION ; INFORMATION
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Biophysics
WOS SubjectBiochemistry & Molecular Biology ; Biophysics
WOS IDWOS:000246253700017
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/9423
Collection09年以前成果
AffiliationChinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Shi, Guihua,Jiang, Tianzi,Zhu, Wanlin,et al. Alignment of two-dimensional electrophoresis gels[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2007,357(2):427-432.
APA Shi, Guihua,Jiang, Tianzi,Zhu, Wanlin,Liu, Bing,&Zhao, Huizhi.(2007).Alignment of two-dimensional electrophoresis gels.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,357(2),427-432.
MLA Shi, Guihua,et al."Alignment of two-dimensional electrophoresis gels".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 357.2(2007):427-432.
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