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Alignment of two-dimensional electrophoresis gels
Shi, Guihua; Jiang, Tianzi; Zhu, Wanlin; Liu, Bing; Zhao, Huizhi
2007-06-01
发表期刊BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷号357期号:2页码:427-432
文章类型Article
摘要Two-dimensional electrophoresis is a major separating technique for proteins in proteomics. Alignment of gel images is critical for intra-laboratory or even more difficult inter-laboratory gel comparisons. In the paper, we propose a novel iterative closest point (ICP) method for 2D-gel electrophoresis image alignment. The paper seeks to introduce an information theoretic measure as one part of distance metric to gel image alignment. We combine intensity information of spots with geometric information of landmarks by applying information potential idea. The proposed method has been applied to both synthetic and real gel images accessible in public 2D-electrophoresis gel protein databases. The high accuracy and robustness of the algorithm indicate that it is promising for gel image alignment. (c) 2007 Elsevier Inc. All rights reserved.
关键词2d-gel Electrophoresis Image Image Alignment Icp Algorithm Informational Potential
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]ELASTIC REGISTRATION ; IMAGE REGISTRATION ; INFORMATION
收录类别SCI
语种英语
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
WOS类目Biochemistry & Molecular Biology ; Biophysics
WOS记录号WOS:000246253700017
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被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/9423
专题09年以前成果
作者单位Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100080, Peoples R China
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Shi, Guihua,Jiang, Tianzi,Zhu, Wanlin,et al. Alignment of two-dimensional electrophoresis gels[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2007,357(2):427-432.
APA Shi, Guihua,Jiang, Tianzi,Zhu, Wanlin,Liu, Bing,&Zhao, Huizhi.(2007).Alignment of two-dimensional electrophoresis gels.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,357(2),427-432.
MLA Shi, Guihua,et al."Alignment of two-dimensional electrophoresis gels".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 357.2(2007):427-432.
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