CASIA OpenIR  > 09年以前成果
Altered functional connectivity in early Alzheimer's disease: A resting-state fMRI study
Wang, Kun; Liang, Meng; Wang, Liang; Tian, Lixia; Zhang, Xinqing; Li, Kuncheng; Jiang, Tianzi
2007-10-01
发表期刊HUMAN BRAIN MAPPING
卷号28期号:10页码:967-978
文章类型Article
摘要Previous studies have led to the proposal that patients with Alzheimer's disease (AD) may have disturbed functional connectivity between different brain regions. Furthermore, recent resting-state functional magnetic resonance imaging (fMRI) studies have also shown that low-frequency (< 0.08 Hz) fluctuations (LFF) of the blood oxygenation level-dependent signals were abnormal in several brain areas of AD patients. However, few studies have investigated disturbed LFF connectivity in AD patients. By using resting-state fMRI, this study sought to investigate the abnormal functional connectivities throughout the entire brain of early AD patients, and analyze the global distribution of these abnormalities. For this purpose, the authors divided the whole brain into 116 regions and identified abnormal connectivities by comparing the correlation coefficients of each pair. Compared with healthy controls, AD patients had decreased positive correlations between the prefrontal and parietal lobes, but increased positive correlations within the prefrontal lobe, parietal lobe, and occipital lobe. The AD patients also had decreased negative correlations (closer to zero) between two intrinsically anti-correlated networks that had previously been found in the resting brain. By using resting-state FVRI, our results supported previous studies that have reported an anterior-posterior disconnection phenomenon and increased within-lobe functional connectivity in AD patients. In addition, the results also suggest that AD may disturb the correlation/anti-correlation effect in the two intrinsically anti-correlated networks.
关键词Alzheimer's Disease Fmri Resting-state Low-frequency Blood Oxygenation Level-dependent Fluctuations Functional Connectivity
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]MILD COGNITIVE IMPAIRMENT ; STAGE ALZHEIMER-DISEASE ; GLUCOSE METABOLIC RATES ; DEFAULT-MODE ; HUMAN BRAIN ; NETWORK ANALYSIS ; LOW-FREQUENCY ; DEMENTIA ; MRI ; TASK
收录类别SCI
语种英语
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000249990700006
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/9457
专题09年以前成果
作者单位1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China
2.Univ Med Sci, Xuanwu Hosp Capital, Dept Radiol, Beijing 100053, Peoples R China
3.Univ Med Sci, Xuanwu Hosp Capital, Dept Neurol, Beijing 100053, Peoples R China
推荐引用方式
GB/T 7714
Wang, Kun,Liang, Meng,Wang, Liang,et al. Altered functional connectivity in early Alzheimer's disease: A resting-state fMRI study[J]. HUMAN BRAIN MAPPING,2007,28(10):967-978.
APA Wang, Kun.,Liang, Meng.,Wang, Liang.,Tian, Lixia.,Zhang, Xinqing.,...&Jiang, Tianzi.(2007).Altered functional connectivity in early Alzheimer's disease: A resting-state fMRI study.HUMAN BRAIN MAPPING,28(10),967-978.
MLA Wang, Kun,et al."Altered functional connectivity in early Alzheimer's disease: A resting-state fMRI study".HUMAN BRAIN MAPPING 28.10(2007):967-978.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Kun]的文章
[Liang, Meng]的文章
[Wang, Liang]的文章
百度学术
百度学术中相似的文章
[Wang, Kun]的文章
[Liang, Meng]的文章
[Wang, Liang]的文章
必应学术
必应学术中相似的文章
[Wang, Kun]的文章
[Liang, Meng]的文章
[Wang, Liang]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。