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Altered functional connectivity in early Alzheimer's disease: A resting-state fMRI study
Wang, Kun; Liang, Meng; Wang, Liang; Tian, Lixia; Zhang, Xinqing; Li, Kuncheng; Jiang, Tianzi
Source PublicationHUMAN BRAIN MAPPING
2007-10-01
Volume28Issue:10Pages:967-978
SubtypeArticle
AbstractPrevious studies have led to the proposal that patients with Alzheimer's disease (AD) may have disturbed functional connectivity between different brain regions. Furthermore, recent resting-state functional magnetic resonance imaging (fMRI) studies have also shown that low-frequency (< 0.08 Hz) fluctuations (LFF) of the blood oxygenation level-dependent signals were abnormal in several brain areas of AD patients. However, few studies have investigated disturbed LFF connectivity in AD patients. By using resting-state fMRI, this study sought to investigate the abnormal functional connectivities throughout the entire brain of early AD patients, and analyze the global distribution of these abnormalities. For this purpose, the authors divided the whole brain into 116 regions and identified abnormal connectivities by comparing the correlation coefficients of each pair. Compared with healthy controls, AD patients had decreased positive correlations between the prefrontal and parietal lobes, but increased positive correlations within the prefrontal lobe, parietal lobe, and occipital lobe. The AD patients also had decreased negative correlations (closer to zero) between two intrinsically anti-correlated networks that had previously been found in the resting brain. By using resting-state FVRI, our results supported previous studies that have reported an anterior-posterior disconnection phenomenon and increased within-lobe functional connectivity in AD patients. In addition, the results also suggest that AD may disturb the correlation/anti-correlation effect in the two intrinsically anti-correlated networks.
KeywordAlzheimer's Disease Fmri Resting-state Low-frequency Blood Oxygenation Level-dependent Fluctuations Functional Connectivity
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordMILD COGNITIVE IMPAIRMENT ; STAGE ALZHEIMER-DISEASE ; GLUCOSE METABOLIC RATES ; DEFAULT-MODE ; HUMAN BRAIN ; NETWORK ANALYSIS ; LOW-FREQUENCY ; DEMENTIA ; MRI ; TASK
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectNeurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000249990700006
Citation statistics
Cited Times:429[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/9457
Collection09年以前成果
Affiliation1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China
2.Univ Med Sci, Xuanwu Hosp Capital, Dept Radiol, Beijing 100053, Peoples R China
3.Univ Med Sci, Xuanwu Hosp Capital, Dept Neurol, Beijing 100053, Peoples R China
Recommended Citation
GB/T 7714
Wang, Kun,Liang, Meng,Wang, Liang,et al. Altered functional connectivity in early Alzheimer's disease: A resting-state fMRI study[J]. HUMAN BRAIN MAPPING,2007,28(10):967-978.
APA Wang, Kun.,Liang, Meng.,Wang, Liang.,Tian, Lixia.,Zhang, Xinqing.,...&Jiang, Tianzi.(2007).Altered functional connectivity in early Alzheimer's disease: A resting-state fMRI study.HUMAN BRAIN MAPPING,28(10),967-978.
MLA Wang, Kun,et al."Altered functional connectivity in early Alzheimer's disease: A resting-state fMRI study".HUMAN BRAIN MAPPING 28.10(2007):967-978.
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