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Spectrally resolved bioluminescence tomography with adaptive finite element analysis: methodology and simulation
Lv, Yujie; Tian, Jie; Cong, Wenxiang; Wang, Ge; Yang, Wei; Qin, Chenghu; Xu, Min
2007-08-07
发表期刊PHYSICS IN MEDICINE AND BIOLOGY
卷号52期号:15页码:4497-4512
文章类型Article
摘要As a molecular imaging technique, bioluminescence tomography (BLT) withits highly sensitive detection and facile operation can significantly reveal molecular and cellular information in vivo at the whole-body small animal level. However, because of complex photon transportation in biological tissue and boundary detection data with high noise, bioluminescent sources in deeper positions generally cannot be localized. In our previous work, we used achromatic or monochromatic measurements and an a priori permissible source region strategy to develop a multilevel adaptive finite-element algorithm. In this paper, we propose a spectrally solved tomographic algorithm with a posteriori permissible source region selection. Multispectral measurements, and anatomical and optical information first deal with the nonuniqueness of BLT and constrain the possible solution of source reconstruction. The use of adaptive mesh refinement and permissible source region based on a posteriori measures not only avoids the dimension disaster arising from the multispectral measured data but also reduces the ill-posedness of BLT and therefore improves the reconstruction quality. Reconsideration of the optimization method and related modifications further enhance reconstruction robustness and efficiency. We also incorporate into the method some improvements for reducing computational burdens. Finally, using a whole-body virtual mouse phantom, we demonstrate the capability of the proposed BLT algorithm to reconstruct accurately bioluminescent sources in deeper positions. In terms of optical property errors and two sources of discernment in deeper positions, this BLT algorithm represents the unique predominance for BLT reconstruction.
关键词Bioluminescence
WOS标题词Science & Technology ; Technology ; Life Sciences & Biomedicine
关键词[WOS]DIFFUSE OPTICAL TOMOGRAPHY ; PET OPET SYSTEM ; IN-VIVO ; GENE-EXPRESSION ; TISSUE ; LIGHT ; GEOMETRIES ; ALGORITHM ; MOUSE
收录类别SCI
语种英语
WOS研究方向Engineering ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Engineering, Biomedical ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000249084000009
引用统计
被引频次:67[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/9488
专题09年以前成果
通讯作者Tian, Jie
作者单位1.Chinese Acad Sci, Inst Automat, Med Image Proc Grp, Beijing 100080, Peoples R China
2.Xidian Univ, Life Sci Ctr, Xian 710071, Peoples R China
3.Virginia Polytech Inst & State Univ, VT WFU Sch Biomed Engn & Sci, Div Biomed Imaging, Blacksburg, VA 24061 USA
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GB/T 7714
Lv, Yujie,Tian, Jie,Cong, Wenxiang,et al. Spectrally resolved bioluminescence tomography with adaptive finite element analysis: methodology and simulation[J]. PHYSICS IN MEDICINE AND BIOLOGY,2007,52(15):4497-4512.
APA Lv, Yujie.,Tian, Jie.,Cong, Wenxiang.,Wang, Ge.,Yang, Wei.,...&Xu, Min.(2007).Spectrally resolved bioluminescence tomography with adaptive finite element analysis: methodology and simulation.PHYSICS IN MEDICINE AND BIOLOGY,52(15),4497-4512.
MLA Lv, Yujie,et al."Spectrally resolved bioluminescence tomography with adaptive finite element analysis: methodology and simulation".PHYSICS IN MEDICINE AND BIOLOGY 52.15(2007):4497-4512.
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