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Spectrally resolved bioluminescence tomography with adaptive finite element analysis: methodology and simulation
Lv, Yujie; Tian, Jie; Cong, Wenxiang; Wang, Ge; Yang, Wei; Qin, Chenghu; Xu, Min
Source PublicationPHYSICS IN MEDICINE AND BIOLOGY
2007-08-07
Volume52Issue:15Pages:4497-4512
SubtypeArticle
AbstractAs a molecular imaging technique, bioluminescence tomography (BLT) withits highly sensitive detection and facile operation can significantly reveal molecular and cellular information in vivo at the whole-body small animal level. However, because of complex photon transportation in biological tissue and boundary detection data with high noise, bioluminescent sources in deeper positions generally cannot be localized. In our previous work, we used achromatic or monochromatic measurements and an a priori permissible source region strategy to develop a multilevel adaptive finite-element algorithm. In this paper, we propose a spectrally solved tomographic algorithm with a posteriori permissible source region selection. Multispectral measurements, and anatomical and optical information first deal with the nonuniqueness of BLT and constrain the possible solution of source reconstruction. The use of adaptive mesh refinement and permissible source region based on a posteriori measures not only avoids the dimension disaster arising from the multispectral measured data but also reduces the ill-posedness of BLT and therefore improves the reconstruction quality. Reconsideration of the optimization method and related modifications further enhance reconstruction robustness and efficiency. We also incorporate into the method some improvements for reducing computational burdens. Finally, using a whole-body virtual mouse phantom, we demonstrate the capability of the proposed BLT algorithm to reconstruct accurately bioluminescent sources in deeper positions. In terms of optical property errors and two sources of discernment in deeper positions, this BLT algorithm represents the unique predominance for BLT reconstruction.
KeywordBioluminescence
WOS HeadingsScience & Technology ; Technology ; Life Sciences & Biomedicine
WOS KeywordDIFFUSE OPTICAL TOMOGRAPHY ; PET OPET SYSTEM ; IN-VIVO ; GENE-EXPRESSION ; TISSUE ; LIGHT ; GEOMETRIES ; ALGORITHM ; MOUSE
Indexed BySCI
Language英语
WOS Research AreaEngineering ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectEngineering, Biomedical ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000249084000009
Citation statistics
Cited Times:67[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/9488
Collection09年以前成果
Corresponding AuthorTian, Jie
Affiliation1.Chinese Acad Sci, Inst Automat, Med Image Proc Grp, Beijing 100080, Peoples R China
2.Xidian Univ, Life Sci Ctr, Xian 710071, Peoples R China
3.Virginia Polytech Inst & State Univ, VT WFU Sch Biomed Engn & Sci, Div Biomed Imaging, Blacksburg, VA 24061 USA
Recommended Citation
GB/T 7714
Lv, Yujie,Tian, Jie,Cong, Wenxiang,et al. Spectrally resolved bioluminescence tomography with adaptive finite element analysis: methodology and simulation[J]. PHYSICS IN MEDICINE AND BIOLOGY,2007,52(15):4497-4512.
APA Lv, Yujie.,Tian, Jie.,Cong, Wenxiang.,Wang, Ge.,Yang, Wei.,...&Xu, Min.(2007).Spectrally resolved bioluminescence tomography with adaptive finite element analysis: methodology and simulation.PHYSICS IN MEDICINE AND BIOLOGY,52(15),4497-4512.
MLA Lv, Yujie,et al."Spectrally resolved bioluminescence tomography with adaptive finite element analysis: methodology and simulation".PHYSICS IN MEDICINE AND BIOLOGY 52.15(2007):4497-4512.
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