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Asymmetry of prefrontal cortical convolution complexity in males with attention-deficit/hyperactivity disorder using fractal information dimension
Li, Xiaobo; Jiang, Jiefeng; Zhu, Wanlin; Yu, Chunshui; Sui, Manqiu; Wang, Yufeng; Jiang, Tianzi
Source PublicationBRAIN & DEVELOPMENT
2007-11-01
Volume29Issue:10Pages:649-655
SubtypeArticle
AbstractBackground and purpose: Prefrontal cortex, known to be a crucial region for the function of attention, is generally thought to be largely associated with the pathogenesis of attention-deficit hyperactivity disorder (ADHD). Most previous structural imaging studies of ADHD reported abnormality of grey matter volume in prefrontal region. However, volume measure is affected by the size of the interrogated brain, which may cause the inconsistence of the volume based findings. The purpose of the current paper is to use a scale-free measure, fractal information dimension (FID), to assess the prefrontal cortical convolution complexity and asymmetry in ADHD patients. Methods: MRI scans from 12 boys with ADHD and 11 controls were carefully processed. Prefrontal cortex was outlined manually. FIDs of bilateral prefrontal cortical surface were examined in each case. Group differences of the bilateral prefrontal cortical convolution complexities and the asymmetry pattern were statistically tested. Results: We found a left-greater-than-right prefrontal cortical convolution complexity pattern in both groups. However, compared with healthy controls, the left prefrontal cortical convolution complexities of ADHD patients were significantly reduced, resulting in significant reduction of the normal left-greater-than-right cortical convolution complexity asymmetry pattern. Conclusion: This study confirms and extends the existing anatomical knowledge about the brains of people with ADHD. The cortical convolution analysis method may also be applied to quantitatively assess changes in other neuropsychiatric syndromes as well. (C) 2007 Elsevier B.V. All rights reserved.
KeywordAnatomic Mri Asymmetry Pattern Attention-deficit Hyperactivity Disorder Cortical Convolution Complexity Information Dimension Prefrontal Cortex
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordDEFICIT HYPERACTIVITY DISORDER ; MAGNETIC-RESONANCE ; FRONTAL-LOBE ; BRAIN-FUNCTION ; CHILDREN ; BOYS ; MRI ; ABNORMALITIES ; ADOLESCENTS ; VARIABILITY
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectClinical Neurology
WOS IDWOS:000250331800007
Citation statistics
Cited Times:31[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/9493
Collection09年以前成果
Affiliation1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China
2.Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China
3.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Li, Xiaobo,Jiang, Jiefeng,Zhu, Wanlin,et al. Asymmetry of prefrontal cortical convolution complexity in males with attention-deficit/hyperactivity disorder using fractal information dimension[J]. BRAIN & DEVELOPMENT,2007,29(10):649-655.
APA Li, Xiaobo.,Jiang, Jiefeng.,Zhu, Wanlin.,Yu, Chunshui.,Sui, Manqiu.,...&Jiang, Tianzi.(2007).Asymmetry of prefrontal cortical convolution complexity in males with attention-deficit/hyperactivity disorder using fractal information dimension.BRAIN & DEVELOPMENT,29(10),649-655.
MLA Li, Xiaobo,et al."Asymmetry of prefrontal cortical convolution complexity in males with attention-deficit/hyperactivity disorder using fractal information dimension".BRAIN & DEVELOPMENT 29.10(2007):649-655.
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