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Structural and functional deficits in human amblyopia
Lv, Bin1; He, Huiguang1; Li, Xingfeng3; Zhang, Zhiqiang2; Huang, Wei2; Li, Meng1; Lu, Guangming2
2008-05-23
发表期刊NEUROSCIENCE LETTERS
卷号437期号:1页码:5-9
文章类型Article
摘要Many neuroimaging tools have been used to assess the site of the cortical deficits in human amblyopia. In this paper, we aimed at detecting the structural and functional deficits in humans with amblyopia, with the aid of anatomic magnetic resonance imaging (aMRI) and functional MRI (fMRI). We designed the visual stimulus to investigate the functional deficits, and delineated the V1/V2 areas by retinotopic mapping. Then we performed the brain parcellation to calculate the volume of the subcortical structure on each individual, and reconstructed the cortical surfaces to measure the cortical thickness. At last, the statistical comparison was carried out to find the structural abnormities and their relationship to the functional deficits. Compared with the normal controls, it is found that the hemisphere difference existed on the unilateral amblyopia subjects, and the functional deficit might come along with the changes in the cortical volume, especially in the occipital lobe. The examined results may provide insight to the study of the neural substrates of amblyopia. Crown Copyright (C) 2008 Published by Elsevier Ireland Ltd. All rights reserved.
关键词Amblyopia Cortical Thickness Visual Cortex Retinotopic Fmri
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]VOXEL-BASED MORPHOMETRY ; ABNORMAL VISUAL-CORTEX ; STRABISMIC AMBLYOPIA ; CORTICAL THICKNESS ; MRI DATA ; CONTRAST ; ADULTS ; AREAS ; FMRI ; ACTIVATION
收录类别SCI
语种英语
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000256201000002
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/9540
专题09年以前成果
作者单位1.Chinese Acad Sci, Key Lab Complex Syst & Intelligence Sci, Inst Automat, Beijing 100190, Peoples R China
2.Nanjing Univ, Dept Med Imaging, Nanjing Jinling Hosp, Nanjing 21002, Peoples R China
3.McGill Univ, McGill Vis Res, Dept Ophthalmol, Montreal, PQ H3A 1A1, Canada
推荐引用方式
GB/T 7714
Lv, Bin,He, Huiguang,Li, Xingfeng,et al. Structural and functional deficits in human amblyopia[J]. NEUROSCIENCE LETTERS,2008,437(1):5-9.
APA Lv, Bin.,He, Huiguang.,Li, Xingfeng.,Zhang, Zhiqiang.,Huang, Wei.,...&Lu, Guangming.(2008).Structural and functional deficits in human amblyopia.NEUROSCIENCE LETTERS,437(1),5-9.
MLA Lv, Bin,et al."Structural and functional deficits in human amblyopia".NEUROSCIENCE LETTERS 437.1(2008):5-9.
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