CASIA OpenIR  > 09年以前成果
Structural and functional deficits in human amblyopia
Lv, Bin1; He, Huiguang1; Li, Xingfeng3; Zhang, Zhiqiang2; Huang, Wei2; Li, Meng1; Lu, Guangming2
Source PublicationNEUROSCIENCE LETTERS
2008-05-23
Volume437Issue:1Pages:5-9
SubtypeArticle
AbstractMany neuroimaging tools have been used to assess the site of the cortical deficits in human amblyopia. In this paper, we aimed at detecting the structural and functional deficits in humans with amblyopia, with the aid of anatomic magnetic resonance imaging (aMRI) and functional MRI (fMRI). We designed the visual stimulus to investigate the functional deficits, and delineated the V1/V2 areas by retinotopic mapping. Then we performed the brain parcellation to calculate the volume of the subcortical structure on each individual, and reconstructed the cortical surfaces to measure the cortical thickness. At last, the statistical comparison was carried out to find the structural abnormities and their relationship to the functional deficits. Compared with the normal controls, it is found that the hemisphere difference existed on the unilateral amblyopia subjects, and the functional deficit might come along with the changes in the cortical volume, especially in the occipital lobe. The examined results may provide insight to the study of the neural substrates of amblyopia. Crown Copyright (C) 2008 Published by Elsevier Ireland Ltd. All rights reserved.
KeywordAmblyopia Cortical Thickness Visual Cortex Retinotopic Fmri
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordVOXEL-BASED MORPHOMETRY ; ABNORMAL VISUAL-CORTEX ; STRABISMIC AMBLYOPIA ; CORTICAL THICKNESS ; MRI DATA ; CONTRAST ; ADULTS ; AREAS ; FMRI ; ACTIVATION
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000256201000002
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/9590
Collection09年以前成果
Affiliation1.Chinese Acad Sci, Key Lab Complex Syst & Intelligence Sci, Inst Automat, Beijing 100190, Peoples R China
2.Nanjing Univ, Dept Med Imaging, Nanjing Jinling Hosp, Nanjing 21002, Peoples R China
3.McGill Univ, McGill Vis Res, Dept Ophthalmol, Montreal, PQ H3A 1A1, Canada
Recommended Citation
GB/T 7714
Lv, Bin,He, Huiguang,Li, Xingfeng,et al. Structural and functional deficits in human amblyopia[J]. NEUROSCIENCE LETTERS,2008,437(1):5-9.
APA Lv, Bin.,He, Huiguang.,Li, Xingfeng.,Zhang, Zhiqiang.,Huang, Wei.,...&Lu, Guangming.(2008).Structural and functional deficits in human amblyopia.NEUROSCIENCE LETTERS,437(1),5-9.
MLA Lv, Bin,et al."Structural and functional deficits in human amblyopia".NEUROSCIENCE LETTERS 437.1(2008):5-9.
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