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An optimal permissible source region strategy for multispectral bioluminescence tomography
Feng, Jinchao1; Jia, Kebin1; Yan, Guorui2; Zhu, Shouping2; Qin, Chenghu2; Lv, Yujie2; Tian, Jie2,3
Source PublicationOPTICS EXPRESS
2008-09-29
Volume16Issue:20Pages:15640-15654
SubtypeArticle
AbstractMultispectral bioluminescence tomography (BLT) attracts increasing more attention in the area of small animal studies because multispectral data acquisition could help in the 3D location of bioluminescent sources. Generally, BLT problem is ill-posed and a priori information is indispensable to reconstruction bioluminescent source uniquely and quantitatively. In this paper, we propose a spectrally solved bioluminescence tomography algorithm with an optimal permissible source region strategy. Being the most different from earlier studies, an optimal permissible source region strategy which is automatically selected without human intervention is developed to reduce the ill-posedness of BLT and therefore improves the reconstruction quality. Furthermore, both numerical stability and computational efficiency benefit from the strategy. In the numerical experiments, a heterogeneous phantom is used to evaluate the proposed algorithm and the synthetic data is produced by Monte Carlo method for avoiding the inverse crime. The results demonstrate the feasibility and potential of our methodology for reconstructing the distribution of bioluminescent sources. (C) 2008 Optical Society of America
KeywordTomography Image Reconstruction Techniques Light Propagation In Tissues Spectroscopy Fluorescence Luminescence
WOS HeadingsScience & Technology ; Physical Sciences
WOS KeywordOPTICAL TOMOGRAPHY ; RECONSTRUCTION METHOD ; SIMULATION ; LIGHT ; MOUSE ; MEDIA
Indexed BySCI
Language英语
WOS Research AreaOptics
WOS SubjectOptics
WOS IDWOS:000260091300038
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Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/9621
Collection09年以前成果
Corresponding AuthorTian, Jie
Affiliation1.Beijing Univ Technol, Coll Elect Informat & Control Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, Med Image Proc Grp, Beijing 100190, Peoples R China
3.Xidian Univ, Life Sci Res Ctr, Xian 710071, Peoples R China
Recommended Citation
GB/T 7714
Feng, Jinchao,Jia, Kebin,Yan, Guorui,et al. An optimal permissible source region strategy for multispectral bioluminescence tomography[J]. OPTICS EXPRESS,2008,16(20):15640-15654.
APA Feng, Jinchao.,Jia, Kebin.,Yan, Guorui.,Zhu, Shouping.,Qin, Chenghu.,...&Tian, Jie.(2008).An optimal permissible source region strategy for multispectral bioluminescence tomography.OPTICS EXPRESS,16(20),15640-15654.
MLA Feng, Jinchao,et al."An optimal permissible source region strategy for multispectral bioluminescence tomography".OPTICS EXPRESS 16.20(2008):15640-15654.
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