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An optimal permissible source region strategy for multispectral bioluminescence tomography
Feng, Jinchao1; Jia, Kebin1; Yan, Guorui2; Zhu, Shouping2; Qin, Chenghu2; Lv, Yujie2; Tian, Jie2,3
2008-09-29
发表期刊OPTICS EXPRESS
卷号16期号:20页码:15640-15654
文章类型Article
摘要Multispectral bioluminescence tomography (BLT) attracts increasing more attention in the area of small animal studies because multispectral data acquisition could help in the 3D location of bioluminescent sources. Generally, BLT problem is ill-posed and a priori information is indispensable to reconstruction bioluminescent source uniquely and quantitatively. In this paper, we propose a spectrally solved bioluminescence tomography algorithm with an optimal permissible source region strategy. Being the most different from earlier studies, an optimal permissible source region strategy which is automatically selected without human intervention is developed to reduce the ill-posedness of BLT and therefore improves the reconstruction quality. Furthermore, both numerical stability and computational efficiency benefit from the strategy. In the numerical experiments, a heterogeneous phantom is used to evaluate the proposed algorithm and the synthetic data is produced by Monte Carlo method for avoiding the inverse crime. The results demonstrate the feasibility and potential of our methodology for reconstructing the distribution of bioluminescent sources. (C) 2008 Optical Society of America
关键词Tomography Image Reconstruction Techniques Light Propagation In Tissues Spectroscopy Fluorescence Luminescence
WOS标题词Science & Technology ; Physical Sciences
关键词[WOS]OPTICAL TOMOGRAPHY ; RECONSTRUCTION METHOD ; SIMULATION ; LIGHT ; MOUSE ; MEDIA
收录类别SCI
语种英语
WOS研究方向Optics
WOS类目Optics
WOS记录号WOS:000260091300038
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/9621
专题09年以前成果
通讯作者Tian, Jie
作者单位1.Beijing Univ Technol, Coll Elect Informat & Control Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, Med Image Proc Grp, Beijing 100190, Peoples R China
3.Xidian Univ, Life Sci Res Ctr, Xian 710071, Peoples R China
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Feng, Jinchao,Jia, Kebin,Yan, Guorui,et al. An optimal permissible source region strategy for multispectral bioluminescence tomography[J]. OPTICS EXPRESS,2008,16(20):15640-15654.
APA Feng, Jinchao.,Jia, Kebin.,Yan, Guorui.,Zhu, Shouping.,Qin, Chenghu.,...&Tian, Jie.(2008).An optimal permissible source region strategy for multispectral bioluminescence tomography.OPTICS EXPRESS,16(20),15640-15654.
MLA Feng, Jinchao,et al."An optimal permissible source region strategy for multispectral bioluminescence tomography".OPTICS EXPRESS 16.20(2008):15640-15654.
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