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Default-mode network activity distinguishes amnestic type mild cognitive impairment from healthy aging: A combined structural and resting-state functional MRI study
Bai, Feng1,2; Zhang, Zhijun1,2; Yu, Hui1,2; Shi, Yongmei1,2; Yuan, Yonggui2; Zhu, Wanlin3,4; Zhang, Xiangrong; Qian, Yun1,2
2008-06-13
发表期刊NEUROSCIENCE LETTERS
卷号438期号:1页码:111-115
文章类型Article
摘要Resting-state functional magnetic resonance imaging (MRI), have revealed coactivation in a distributed network that characterizes the default-mode in the human brain. However, details from resting-state imaging in amnestic type mild cognitive impairment (aMCI) is poorly understand. Regional homogeneity, which characterizes low-frequency blood oxygenation level dependent fluctuation, after statistically controlling for the regional atrophy and age in resting-state, were examined and compared between the two groups. When regional atrophy was controlled, decreased regional homogeneity in posterior cingulate cortex and precuneus still remained significant in aMCI patients. In addition the aMCI subjects displayed several regions of increased homogeneity, typically in right inferior parietal lobule, right fusiform gyrus and bilateral putamen. The impairment of posterior cingulate and precuneus could be an important marker to distinguish aMCI from healthy aging in the resting-state. Moreover, the increased regional homogeneity changes would be consistent with compensation for damage to the medial temporal regions and limbic structures, perhaps by recruitment of alternative regions. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
关键词Mild Cognitive Impairment Default-mode Resting-state Voxel-based Morphometry Low-frequency Fluctuation
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]VOXEL-BASED MORPHOMETRY ; GRAY-MATTER LOSS ; ALZHEIMERS-DISEASE ; MAGNETIC-RESONANCE ; REGIONAL HOMOGENEITY ; EPISODIC MEMORY ; HUMAN BRAIN ; CONNECTIVITY ; FMRI ; HYPOMETABOLISM
收录类别SCI
语种英语
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000257152000025
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文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/9629
专题09年以前成果
作者单位1.SE Univ, Affiliated ZhongDa Hosp, Dept Neurol, Nanjing 210009, Peoples R China
2.SE Univ, Sch Clin Med, Nanjing 210009, Peoples R China
3.Zhejiang Univ, Dept Math, Hangzhou 310027, Peoples R China
4.Chinese Acad Sci, Inst Automat, Beijing 100875, Peoples R China
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Bai, Feng,Zhang, Zhijun,Yu, Hui,et al. Default-mode network activity distinguishes amnestic type mild cognitive impairment from healthy aging: A combined structural and resting-state functional MRI study[J]. NEUROSCIENCE LETTERS,2008,438(1):111-115.
APA Bai, Feng.,Zhang, Zhijun.,Yu, Hui.,Shi, Yongmei.,Yuan, Yonggui.,...&Qian, Yun.(2008).Default-mode network activity distinguishes amnestic type mild cognitive impairment from healthy aging: A combined structural and resting-state functional MRI study.NEUROSCIENCE LETTERS,438(1),111-115.
MLA Bai, Feng,et al."Default-mode network activity distinguishes amnestic type mild cognitive impairment from healthy aging: A combined structural and resting-state functional MRI study".NEUROSCIENCE LETTERS 438.1(2008):111-115.
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