Fisher discriminative analysis of resting-state brain function for attention-deficit/hyperactivity disorder

CASIA OpenIR > 09年以前成果

	Fisher discriminative analysis of resting-state brain function for attention-deficit/hyperactivity disorder
	Zhu, Chao-Zhe 1,2; Zang, Yu-Feng 1,2; Cao, Qing-Jiu 3; Yan, Chao-Gan 1; He, Yong 4; Jiang, Tian-Zi2 ; Sui, Man-Qiu 3; Wang, Yu-Feng 3
发表期刊	NEUROIMAGE
	2008-03-01
卷号	40 期号:1 页码:110-120
文章类型	Article
摘要	In this study a resting-state fMRI based classifier, for the first time, was proposed and applied to discriminate children with attention-deficit/hyperactivity disorder (ADHD) from normal controls. On the basis of regional homogeneity (ReHo), a mapping of brain function at resting state, PCA-based Fisher discriminative analysis (PC-FDA) was trained to build a linear classifier. Permutation test was then conducted to identify the brain areas with the most significant contribution to the final discrimination. Experimental results showed a correct classification rate of 85% using a leave-one-out cross-validation. Moreover, some highly discriminative brain regions, like the prefrontal cortex and anterior cingulate cortex, well confirmed the previous findings on ADHD. Interestingly, some important but less reported regions such as the thalamus were also identified. We conclude that the classifier, using resting-state brain function as classification feature, has potential ability to improve current diagnosis and treatment evaluation of ADHD. (c) 2007 Published by Elsevier Inc.
关键词	Fisher Discriminative Analysis Adhd Reho Resting State Fmri
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	DEFICIT HYPERACTIVITY DISORDER ; ANTERIOR CINGULATE CORTEX ; REGIONAL HOMOGENEITY ; PERFORMANCE METRICS ; ACTIVATION PATTERNS ; ALZHEIMERS-DISEASE ; CONNECTIVITY ; MRI ; CLASSIFICATION ; CHILDREN
收录类别	SCI
语种	英语
WOS研究方向	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000253362100012
引用统计	被引频次：189[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/9654
专题	09年以前成果
作者单位	1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100875, Peoples R China 3.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China 4.McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging, Montreal, PQ H3A 2B4, Canada
第一作者单位	模式识别国家重点实验室
推荐引用方式 GB/T 7714	Zhu, Chao-Zhe,Zang, Yu-Feng,Cao, Qing-Jiu,et al. Fisher discriminative analysis of resting-state brain function for attention-deficit/hyperactivity disorder[J]. NEUROIMAGE,2008,40(1):110-120.
APA	Zhu, Chao-Zhe.,Zang, Yu-Feng.,Cao, Qing-Jiu.,Yan, Chao-Gan.,He, Yong.,...&Wang, Yu-Feng.(2008).Fisher discriminative analysis of resting-state brain function for attention-deficit/hyperactivity disorder.NEUROIMAGE,40(1),110-120.
MLA	Zhu, Chao-Zhe,et al."Fisher discriminative analysis of resting-state brain function for attention-deficit/hyperactivity disorder".NEUROIMAGE 40.1(2008):110-120.