CASIA OpenIR  > 09年以前成果
Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophrenia
Zhou, Yuan3; Shu, Ni3; Liu, Yong3; Song, Ming3; Hao, Yihui1; Liu, Haihong1; Yu, Chunshui2; Liu, Zhening1; Jiang, Tianzi3
2008-03-01
发表期刊SCHIZOPHRENIA RESEARCH
卷号100期号:1-3页码:120-132
文章类型Article
摘要Hippocampus has been implicated in participating in the pathophysiology of schizophrenia. However, the functional and anatomical connectivities between hippocampus and other regions are rarely concurrently investigated in schizophrenia. In the present study, both functional magnetic resonance imaging (fMRI) during rest and diffusion tensor imaging (DTI) were performed on 17 patients with paranoid schizophrenia and 14 healthy subjects. Resting-state functional connectivities of the bilateral hippocampi were separately analyzed by selecting the anterior hippocampus as region of interest. The fornix body was reconstructed by diffusion tensor tractography, and the integrity of this tract was evaluated using fractional anisotropy (FA). In patients with schizophrenia, the bilateral hippocampi showed reduced functional connectivities to some regions which have been reported to be involved in episodic memory, such as posterior cingulate cortex, extrastriate cortex, medial prefrontal cortex, and parahippocampus gyrus. We speculated that these reduced connectivity may reflect the disconnectivity within a neural network related to the anterior hippocampus in schizophrenia. Meanwhile the mean FA of the fornix body was significantly reduced in patients, indicating the damage in the hippocampal anatomical connectivity in schizophrenia. The concurrence of the functional disconnectivity and damaged anatomical connectivity between the hippocampus and other regions in schizophrenia suggest that the functional-anatomical relationship need to be further investigated. (C) 2007 Elsevier B.V. All rights reserved.
关键词Schizophrenia Hippocampus Fmri Diffusion Tensor Tractography Functional Connectivity Anatomical Connectivity
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]POSITRON-EMISSION-TOMOGRAPHY ; WHITE-MATTER INTEGRITY ; 1ST-EPISODE SCHIZOPHRENIA ; HUMAN BRAIN ; EPISODIC MEMORY ; DEFAULT MODE ; VOLUME REDUCTIONS ; BOLD SIGNAL ; CORTEX ; FMRI
收录类别SCI ; SSCI
语种英语
WOS研究方向Psychiatry
WOS类目Psychiatry
WOS记录号WOS:000254722400011
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/9692
专题09年以前成果
作者单位1.Cent S Univ, Xiangya Hosp 2, Inst Mental Hlth, Changsha 410011, Peoples R China
2.Capital Univ Med Sci, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China
3.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100080, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Yuan,Shu, Ni,Liu, Yong,et al. Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2008,100(1-3):120-132.
APA Zhou, Yuan.,Shu, Ni.,Liu, Yong.,Song, Ming.,Hao, Yihui.,...&Jiang, Tianzi.(2008).Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophrenia.SCHIZOPHRENIA RESEARCH,100(1-3),120-132.
MLA Zhou, Yuan,et al."Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophrenia".SCHIZOPHRENIA RESEARCH 100.1-3(2008):120-132.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhou, Yuan]的文章
[Shu, Ni]的文章
[Liu, Yong]的文章
百度学术
百度学术中相似的文章
[Zhou, Yuan]的文章
[Shu, Ni]的文章
[Liu, Yong]的文章
必应学术
必应学术中相似的文章
[Zhou, Yuan]的文章
[Shu, Ni]的文章
[Liu, Yong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。