Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophrenia

CASIA OpenIR > 09年以前成果

	Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophrenia
	Zhou, Yuan 3; Shu, Ni 3; Liu, Yong3 ; Song, Ming3 ; Hao, Yihui 1; Liu, Haihong 1; Yu, Chunshui 2; Liu, Zhening 1; Jiang, Tianzi3
发表期刊	SCHIZOPHRENIA RESEARCH
	2008-03-01
卷号	100 期号:1-3 页码:120-132
文章类型	Article
摘要	Hippocampus has been implicated in participating in the pathophysiology of schizophrenia. However, the functional and anatomical connectivities between hippocampus and other regions are rarely concurrently investigated in schizophrenia. In the present study, both functional magnetic resonance imaging (fMRI) during rest and diffusion tensor imaging (DTI) were performed on 17 patients with paranoid schizophrenia and 14 healthy subjects. Resting-state functional connectivities of the bilateral hippocampi were separately analyzed by selecting the anterior hippocampus as region of interest. The fornix body was reconstructed by diffusion tensor tractography, and the integrity of this tract was evaluated using fractional anisotropy (FA). In patients with schizophrenia, the bilateral hippocampi showed reduced functional connectivities to some regions which have been reported to be involved in episodic memory, such as posterior cingulate cortex, extrastriate cortex, medial prefrontal cortex, and parahippocampus gyrus. We speculated that these reduced connectivity may reflect the disconnectivity within a neural network related to the anterior hippocampus in schizophrenia. Meanwhile the mean FA of the fornix body was significantly reduced in patients, indicating the damage in the hippocampal anatomical connectivity in schizophrenia. The concurrence of the functional disconnectivity and damaged anatomical connectivity between the hippocampus and other regions in schizophrenia suggest that the functional-anatomical relationship need to be further investigated. (C) 2007 Elsevier B.V. All rights reserved.
关键词	Schizophrenia Hippocampus Fmri Diffusion Tensor Tractography Functional Connectivity Anatomical Connectivity
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]	POSITRON-EMISSION-TOMOGRAPHY ; WHITE-MATTER INTEGRITY ; 1ST-EPISODE SCHIZOPHRENIA ; HUMAN BRAIN ; EPISODIC MEMORY ; DEFAULT MODE ; VOLUME REDUCTIONS ; BOLD SIGNAL ; CORTEX ; FMRI
收录类别	SCI ; SSCI
语种	英语
WOS研究方向	Psychiatry
WOS类目	Psychiatry
WOS记录号	WOS:000254722400011
引用统计	被引频次：240[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/9692
专题	09年以前成果
作者单位	1.Cent S Univ, Xiangya Hosp 2, Inst Mental Hlth, Changsha 410011, Peoples R China 2.Capital Univ Med Sci, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China 3.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100080, Peoples R China
第一作者单位	模式识别国家重点实验室
推荐引用方式 GB/T 7714	Zhou, Yuan,Shu, Ni,Liu, Yong,et al. Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2008,100(1-3):120-132.
APA	Zhou, Yuan.,Shu, Ni.,Liu, Yong.,Song, Ming.,Hao, Yihui.,...&Jiang, Tianzi.(2008).Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophrenia.SCHIZOPHRENIA RESEARCH,100(1-3),120-132.
MLA	Zhou, Yuan,et al."Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophrenia".SCHIZOPHRENIA RESEARCH 100.1-3(2008):120-132.