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Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophrenia
Zhou, Yuan3; Shu, Ni3; Liu, Yong3; Song, Ming3; Hao, Yihui1; Liu, Haihong1; Yu, Chunshui2; Liu, Zhening1; Jiang, Tianzi3
Source PublicationSCHIZOPHRENIA RESEARCH
2008-03-01
Volume100Issue:1-3Pages:120-132
SubtypeArticle
AbstractHippocampus has been implicated in participating in the pathophysiology of schizophrenia. However, the functional and anatomical connectivities between hippocampus and other regions are rarely concurrently investigated in schizophrenia. In the present study, both functional magnetic resonance imaging (fMRI) during rest and diffusion tensor imaging (DTI) were performed on 17 patients with paranoid schizophrenia and 14 healthy subjects. Resting-state functional connectivities of the bilateral hippocampi were separately analyzed by selecting the anterior hippocampus as region of interest. The fornix body was reconstructed by diffusion tensor tractography, and the integrity of this tract was evaluated using fractional anisotropy (FA). In patients with schizophrenia, the bilateral hippocampi showed reduced functional connectivities to some regions which have been reported to be involved in episodic memory, such as posterior cingulate cortex, extrastriate cortex, medial prefrontal cortex, and parahippocampus gyrus. We speculated that these reduced connectivity may reflect the disconnectivity within a neural network related to the anterior hippocampus in schizophrenia. Meanwhile the mean FA of the fornix body was significantly reduced in patients, indicating the damage in the hippocampal anatomical connectivity in schizophrenia. The concurrence of the functional disconnectivity and damaged anatomical connectivity between the hippocampus and other regions in schizophrenia suggest that the functional-anatomical relationship need to be further investigated. (C) 2007 Elsevier B.V. All rights reserved.
KeywordSchizophrenia Hippocampus Fmri Diffusion Tensor Tractography Functional Connectivity Anatomical Connectivity
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordPOSITRON-EMISSION-TOMOGRAPHY ; WHITE-MATTER INTEGRITY ; 1ST-EPISODE SCHIZOPHRENIA ; HUMAN BRAIN ; EPISODIC MEMORY ; DEFAULT MODE ; VOLUME REDUCTIONS ; BOLD SIGNAL ; CORTEX ; FMRI
Indexed BySCI ; SSCI
Language英语
WOS Research AreaPsychiatry
WOS SubjectPsychiatry
WOS IDWOS:000254722400011
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Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/9692
Collection09年以前成果
Affiliation1.Cent S Univ, Xiangya Hosp 2, Inst Mental Hlth, Changsha 410011, Peoples R China
2.Capital Univ Med Sci, Xuanwu Hosp, Dept Radiol, Beijing 100053, Peoples R China
3.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100080, Peoples R China
First Author AffilicationChinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Yuan,Shu, Ni,Liu, Yong,et al. Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophrenia[J]. SCHIZOPHRENIA RESEARCH,2008,100(1-3):120-132.
APA Zhou, Yuan.,Shu, Ni.,Liu, Yong.,Song, Ming.,Hao, Yihui.,...&Jiang, Tianzi.(2008).Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophrenia.SCHIZOPHRENIA RESEARCH,100(1-3),120-132.
MLA Zhou, Yuan,et al."Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophrenia".SCHIZOPHRENIA RESEARCH 100.1-3(2008):120-132.
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