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Reduced Cortical Thickness in Mental Retardation
Zhang, Yuanchao1; Wu, Yan1; Zhu, Maohu2; Wang, Chao1; Wang, Jiaojian1; Zhang, Yun1; Yu, Chunshui3; Jiang, Tianzi1,2
发表期刊PLOS ONE
2011-12-27
卷号6期号:12
文章类型Article
摘要Mental retardation is a developmental disorder associated with impaired cognitive functioning and deficits in adaptive behaviors. Many studies have addressed white matter abnormalities in patients with mental retardation, while the changes of the cerebral cortex have been studied to a lesser extent. Quantitative analysis of cortical integrity using cortical thickness measurement may provide new insights into the gray matter pathology. In this study, cortical thickness was compared between 13 patients with mental retardation and 26 demographically matched healthy controls. We found that patients with mental retardation had significantly reduced cortical thickness in multiple brain regions compared with healthy controls. These regions include the bilateral lingual gyrus, the bilateral fusiform gyrus, the bilateral parahippocampal gyrus, the bilateral temporal pole, the left inferior temporal gyrus, the right lateral orbitofrontal cortex and the right precentral gyrus. The observed cortical thickness reductions might be the anatomical substrates for the impaired cognitive functioning and deficits in adaptive behaviors in patients with mental retardation. Cortical thickness measurement might provide a sensitive prospective surrogate marker for clinical trials of neuroprotective medications.
WOS标题词Science & Technology
关键词[WOS]VOXEL-BASED MORPHOMETRY ; SURFACE-BASED ANALYSIS ; HUMAN CEREBRAL-CORTEX ; FRAGILE-X-SYNDROME ; DENDRITIC SPINE ; WORKING-MEMORY ; LEARNING-DISABILITY ; INTELLECTUAL DISABILITY ; COMORBID SCHIZOPHRENIA ; DEVELOPMENTAL DELAY
收录类别SCI
语种英语
WOS研究方向Science & Technology - Other Topics
WOS类目Multidisciplinary Sciences
WOS记录号WOS:000300674900052
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/9732
专题脑网络组研究中心
作者单位1.Univ Elect Sci & Technol China, Key Lab NeuroInformat Minist Educ, Sch Life Sci & Technol, Chengdu 610054, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, LIAMA Ctr Computat Med, Beijing, Peoples R China
3.Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin, Peoples R China
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GB/T 7714
Zhang, Yuanchao,Wu, Yan,Zhu, Maohu,et al. Reduced Cortical Thickness in Mental Retardation[J]. PLOS ONE,2011,6(12).
APA Zhang, Yuanchao.,Wu, Yan.,Zhu, Maohu.,Wang, Chao.,Wang, Jiaojian.,...&Jiang, Tianzi.(2011).Reduced Cortical Thickness in Mental Retardation.PLOS ONE,6(12).
MLA Zhang, Yuanchao,et al."Reduced Cortical Thickness in Mental Retardation".PLOS ONE 6.12(2011).
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