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Reduced Cortical Thickness in Mental Retardation
Zhang, Yuanchao1; Wu, Yan1; Zhu, Maohu2; Wang, Chao1; Wang, Jiaojian1; Zhang, Yun1; Yu, Chunshui3; Jiang, Tianzi1,2
Source PublicationPLOS ONE
2011-12-27
Volume6Issue:12
SubtypeArticle
AbstractMental retardation is a developmental disorder associated with impaired cognitive functioning and deficits in adaptive behaviors. Many studies have addressed white matter abnormalities in patients with mental retardation, while the changes of the cerebral cortex have been studied to a lesser extent. Quantitative analysis of cortical integrity using cortical thickness measurement may provide new insights into the gray matter pathology. In this study, cortical thickness was compared between 13 patients with mental retardation and 26 demographically matched healthy controls. We found that patients with mental retardation had significantly reduced cortical thickness in multiple brain regions compared with healthy controls. These regions include the bilateral lingual gyrus, the bilateral fusiform gyrus, the bilateral parahippocampal gyrus, the bilateral temporal pole, the left inferior temporal gyrus, the right lateral orbitofrontal cortex and the right precentral gyrus. The observed cortical thickness reductions might be the anatomical substrates for the impaired cognitive functioning and deficits in adaptive behaviors in patients with mental retardation. Cortical thickness measurement might provide a sensitive prospective surrogate marker for clinical trials of neuroprotective medications.
WOS HeadingsScience & Technology
WOS KeywordVOXEL-BASED MORPHOMETRY ; SURFACE-BASED ANALYSIS ; HUMAN CEREBRAL-CORTEX ; FRAGILE-X-SYNDROME ; DENDRITIC SPINE ; WORKING-MEMORY ; LEARNING-DISABILITY ; INTELLECTUAL DISABILITY ; COMORBID SCHIZOPHRENIA ; DEVELOPMENTAL DELAY
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000300674900052
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/9732
Collection脑网络组研究中心
Affiliation1.Univ Elect Sci & Technol China, Key Lab NeuroInformat Minist Educ, Sch Life Sci & Technol, Chengdu 610054, Peoples R China
2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, LIAMA Ctr Computat Med, Beijing, Peoples R China
3.Tianjin Med Univ Gen Hosp, Dept Radiol, Tianjin, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Yuanchao,Wu, Yan,Zhu, Maohu,et al. Reduced Cortical Thickness in Mental Retardation[J]. PLOS ONE,2011,6(12).
APA Zhang, Yuanchao.,Wu, Yan.,Zhu, Maohu.,Wang, Chao.,Wang, Jiaojian.,...&Jiang, Tianzi.(2011).Reduced Cortical Thickness in Mental Retardation.PLOS ONE,6(12).
MLA Zhang, Yuanchao,et al."Reduced Cortical Thickness in Mental Retardation".PLOS ONE 6.12(2011).
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