CASIA OpenIR  > 中国科学院分子影像重点实验室
Whole-Body Cerenkov Luminescence Tomography with the Finite Element SP3 Method
Zhong, Jianghong; Tian, Jie; Yang, Xin; Qin, Chenghu
Source PublicationANNALS OF BIOMEDICAL ENGINEERING
2011-06-01
Volume39Issue:6Pages:1728-1735
SubtypeArticle
AbstractGeneration of an accurate Cerenkov luminescence imaging model is a current issue of nuclear tomography with optical techniques. The article takes a pro-active approach toward whole-body Cerenkov luminescence tomography. The finite element framework employs the equation of radiative transfer via the third-order simplified spherical harmonics approximation to model Cerenkov photon propagation in a small animal. After this forward model is performed on a digital mouse with optical property heterogeneity and compared with the Monte Carlo method, we investigated the whole body reconstruction algorithm along a regularization path via coordinate descent. The endpoint of the follow-up study is the in vivo application, which provides three-dimensional biodistribution of the radiotracer uptake in the mouse from measured partial boundary currents. The combination of the forward and inverse model with elastic-net penalties is not only validated by numerical simulation, but it also effectively demonstrates in vivo imaging in small animals. Our exact reconstruction method enables optical molecular imaging to best utilize Cerenkov radiation emission from the decay of medical isotopes in tissues.
KeywordCerenkov Mathematical Model Light Propagation In Tissues Tomography Molecular Imaging
WOS HeadingsScience & Technology ; Technology
WOS KeywordSPHERICAL-HARMONICS APPROXIMATION ; POSITRON-EMITTING RADIOTRACERS ; BIOLUMINESCENCE TOMOGRAPHY ; RADIATION ; MODELS
Indexed BySCI
Language英语
WOS Research AreaEngineering
WOS SubjectEngineering, Biomedical
WOS IDWOS:000290724900012
Citation statistics
Cited Times:34[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/9753
Collection中国科学院分子影像重点实验室
Corresponding AuthorTian, Jie
AffiliationChinese Acad Sci, Med Image Proc Grp, Inst Automat, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhong, Jianghong,Tian, Jie,Yang, Xin,et al. Whole-Body Cerenkov Luminescence Tomography with the Finite Element SP3 Method[J]. ANNALS OF BIOMEDICAL ENGINEERING,2011,39(6):1728-1735.
APA Zhong, Jianghong,Tian, Jie,Yang, Xin,&Qin, Chenghu.(2011).Whole-Body Cerenkov Luminescence Tomography with the Finite Element SP3 Method.ANNALS OF BIOMEDICAL ENGINEERING,39(6),1728-1735.
MLA Zhong, Jianghong,et al."Whole-Body Cerenkov Luminescence Tomography with the Finite Element SP3 Method".ANNALS OF BIOMEDICAL ENGINEERING 39.6(2011):1728-1735.
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