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Whole-Body Cerenkov Luminescence Tomography with the Finite Element SP3 Method
Zhong, Jianghong; Tian, Jie; Yang, Xin; Qin, Chenghu
2011-06-01
发表期刊ANNALS OF BIOMEDICAL ENGINEERING
卷号39期号:6页码:1728-1735
文章类型Article
摘要Generation of an accurate Cerenkov luminescence imaging model is a current issue of nuclear tomography with optical techniques. The article takes a pro-active approach toward whole-body Cerenkov luminescence tomography. The finite element framework employs the equation of radiative transfer via the third-order simplified spherical harmonics approximation to model Cerenkov photon propagation in a small animal. After this forward model is performed on a digital mouse with optical property heterogeneity and compared with the Monte Carlo method, we investigated the whole body reconstruction algorithm along a regularization path via coordinate descent. The endpoint of the follow-up study is the in vivo application, which provides three-dimensional biodistribution of the radiotracer uptake in the mouse from measured partial boundary currents. The combination of the forward and inverse model with elastic-net penalties is not only validated by numerical simulation, but it also effectively demonstrates in vivo imaging in small animals. Our exact reconstruction method enables optical molecular imaging to best utilize Cerenkov radiation emission from the decay of medical isotopes in tissues.
关键词Cerenkov Mathematical Model Light Propagation In Tissues Tomography Molecular Imaging
WOS标题词Science & Technology ; Technology
关键词[WOS]SPHERICAL-HARMONICS APPROXIMATION ; POSITRON-EMITTING RADIOTRACERS ; BIOLUMINESCENCE TOMOGRAPHY ; RADIATION ; MODELS
收录类别SCI
语种英语
WOS研究方向Engineering
WOS类目Engineering, Biomedical
WOS记录号WOS:000290724900012
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/9753
专题中国科学院分子影像重点实验室
通讯作者Tian, Jie
作者单位Chinese Acad Sci, Med Image Proc Grp, Inst Automat, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714
Zhong, Jianghong,Tian, Jie,Yang, Xin,et al. Whole-Body Cerenkov Luminescence Tomography with the Finite Element SP3 Method[J]. ANNALS OF BIOMEDICAL ENGINEERING,2011,39(6):1728-1735.
APA Zhong, Jianghong,Tian, Jie,Yang, Xin,&Qin, Chenghu.(2011).Whole-Body Cerenkov Luminescence Tomography with the Finite Element SP3 Method.ANNALS OF BIOMEDICAL ENGINEERING,39(6),1728-1735.
MLA Zhong, Jianghong,et al."Whole-Body Cerenkov Luminescence Tomography with the Finite Element SP3 Method".ANNALS OF BIOMEDICAL ENGINEERING 39.6(2011):1728-1735.
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