Whole-Body Cerenkov Luminescence Tomography with the Finite Element SP3 Method

	Whole-Body Cerenkov Luminescence Tomography with the Finite Element SP3 Method
	Zhong, Jianghong; Tian, Jie; Yang, Xin; Qin, Chenghu
发表期刊	ANNALS OF BIOMEDICAL ENGINEERING
	2011-06-01
卷号	39 期号:6 页码:1728-1735
文章类型	Article
摘要	Generation of an accurate Cerenkov luminescence imaging model is a current issue of nuclear tomography with optical techniques. The article takes a pro-active approach toward whole-body Cerenkov luminescence tomography. The finite element framework employs the equation of radiative transfer via the third-order simplified spherical harmonics approximation to model Cerenkov photon propagation in a small animal. After this forward model is performed on a digital mouse with optical property heterogeneity and compared with the Monte Carlo method, we investigated the whole body reconstruction algorithm along a regularization path via coordinate descent. The endpoint of the follow-up study is the in vivo application, which provides three-dimensional biodistribution of the radiotracer uptake in the mouse from measured partial boundary currents. The combination of the forward and inverse model with elastic-net penalties is not only validated by numerical simulation, but it also effectively demonstrates in vivo imaging in small animals. Our exact reconstruction method enables optical molecular imaging to best utilize Cerenkov radiation emission from the decay of medical isotopes in tissues.
关键词	Cerenkov Mathematical Model Light Propagation In Tissues Tomography Molecular Imaging
WOS标题词	Science & Technology ; Technology
关键词[WOS]	SPHERICAL-HARMONICS APPROXIMATION ; POSITRON-EMITTING RADIOTRACERS ; BIOLUMINESCENCE TOMOGRAPHY ; RADIATION ; MODELS
收录类别	SCI
语种	英语
WOS研究方向	Engineering
WOS类目	Engineering, Biomedical
WOS记录号	WOS:000290724900012
引用统计	被引频次：57[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/9753
专题	中国科学院分子影像重点实验室
通讯作者	Tian, Jie
作者单位	Chinese Acad Sci, Med Image Proc Grp, Inst Automat, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Zhong, Jianghong,Tian, Jie,Yang, Xin,et al. Whole-Body Cerenkov Luminescence Tomography with the Finite Element SP3 Method[J]. ANNALS OF BIOMEDICAL ENGINEERING,2011,39(6):1728-1735.
APA	Zhong, Jianghong,Tian, Jie,Yang, Xin,&Qin, Chenghu.(2011).Whole-Body Cerenkov Luminescence Tomography with the Finite Element SP3 Method.ANNALS OF BIOMEDICAL ENGINEERING,39(6),1728-1735.
MLA	Zhong, Jianghong,et al."Whole-Body Cerenkov Luminescence Tomography with the Finite Element SP3 Method".ANNALS OF BIOMEDICAL ENGINEERING 39.6(2011):1728-1735.

条目包含的文件		下载所有文件
文件名称/大小	文献类型	版本类型	开放类型	使用许可
163.Annals of Biomed（837KB）	期刊论文	作者接受稿	开放获取	CC BY-NC-SA	浏览下载