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DISCRIMINATIVE ANALYSIS OF FUNCTIONAL NEAR-INFRARED SPECTROSCOPY SIGNALS FOR DEVELOPMENT OF NEUROIMAGING BIOMARKERS OF ELDERLY DEPRESSION
Zhu, Ye1; Jiang, Tianzi1; Zhou, Yuan1; Zhao, Lisha2
Source PublicationJOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES
2010
Volume3Issue:1Pages:69-74
SubtypeArticle
AbstractFunctional near-infrared spectroscopy (fNIRS) is a neuroimaging technology which is suitable for psychiatric patients. Several fNIRS studies have found abnormal brain activations during cognitive tasks in elderly depression. In this paper, we proposed a discriminative model of multivariate pattern classification based on fNIRS signals to distinguish elderly depressed patients from healthy controls. This model used the brain activation patterns during a verbal fluency task as features of classification. Then Pseudo-Fisher Linear Discriminant Analysis was performed on the feature space to generate discriminative model. Using leave-one-out (LOO) cross-validation, our results showed a correct classification rate of 88%. The discriminative model showed its ability to identify people with elderly depression and suggested that fNIRS may be an efficient clinical tool for diagnosis of depression. This study may provide the first step for the development of neuroimaging biomarkers based on fNIRS in psychiatric disorders.
KeywordFunctional Near-infrared Spectroscopy (Fnirs) Fisher Linear Discriminant Analysis (Flda) Depression
WOS HeadingsScience & Technology ; Physical Sciences ; Life Sciences & Biomedicine
Indexed BySCI
Language英语
WOS Research AreaOptics ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectOptics ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000208647600010
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/9945
Collection脑网络组研究中心
Affiliation1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China
2.Capital Univ Med Sci, Beijing Anding Hosp, Beijing 100088, Peoples R China
Recommended Citation
GB/T 7714
Zhu, Ye,Jiang, Tianzi,Zhou, Yuan,et al. DISCRIMINATIVE ANALYSIS OF FUNCTIONAL NEAR-INFRARED SPECTROSCOPY SIGNALS FOR DEVELOPMENT OF NEUROIMAGING BIOMARKERS OF ELDERLY DEPRESSION[J]. JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES,2010,3(1):69-74.
APA Zhu, Ye,Jiang, Tianzi,Zhou, Yuan,&Zhao, Lisha.(2010).DISCRIMINATIVE ANALYSIS OF FUNCTIONAL NEAR-INFRARED SPECTROSCOPY SIGNALS FOR DEVELOPMENT OF NEUROIMAGING BIOMARKERS OF ELDERLY DEPRESSION.JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES,3(1),69-74.
MLA Zhu, Ye,et al."DISCRIMINATIVE ANALYSIS OF FUNCTIONAL NEAR-INFRARED SPECTROSCOPY SIGNALS FOR DEVELOPMENT OF NEUROIMAGING BIOMARKERS OF ELDERLY DEPRESSION".JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES 3.1(2010):69-74.
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