DISCRIMINATIVE ANALYSIS OF FUNCTIONAL NEAR-INFRARED SPECTROSCOPY SIGNALS FOR DEVELOPMENT OF NEUROIMAGING BIOMARKERS OF ELDERLY DEPRESSION

	DISCRIMINATIVE ANALYSIS OF FUNCTIONAL NEAR-INFRARED SPECTROSCOPY SIGNALS FOR DEVELOPMENT OF NEUROIMAGING BIOMARKERS OF ELDERLY DEPRESSION
	Zhu, Ye 1; Jiang, Tianzi1 ; Zhou, Yuan 1; Zhao, Lisha 2
发表期刊	JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES
	2010
卷号	3 期号:1 页码:69-74
文章类型	Article
摘要	Functional near-infrared spectroscopy (fNIRS) is a neuroimaging technology which is suitable for psychiatric patients. Several fNIRS studies have found abnormal brain activations during cognitive tasks in elderly depression. In this paper, we proposed a discriminative model of multivariate pattern classification based on fNIRS signals to distinguish elderly depressed patients from healthy controls. This model used the brain activation patterns during a verbal fluency task as features of classification. Then Pseudo-Fisher Linear Discriminant Analysis was performed on the feature space to generate discriminative model. Using leave-one-out (LOO) cross-validation, our results showed a correct classification rate of 88%. The discriminative model showed its ability to identify people with elderly depression and suggested that fNIRS may be an efficient clinical tool for diagnosis of depression. This study may provide the first step for the development of neuroimaging biomarkers based on fNIRS in psychiatric disorders.
关键词	Functional Near-infrared Spectroscopy (Fnirs) Fisher Linear Discriminant Analysis (Flda) Depression
WOS标题词	Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine
收录类别	SCI
语种	英语
WOS研究方向	Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目	Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:000208647600010
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.ia.ac.cn/handle/173211/9945
专题	脑图谱与类脑智能实验室_脑网络组研究
作者单位	1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China 2.Capital Univ Med Sci, Beijing Anding Hosp, Beijing 100088, Peoples R China
第一作者单位	模式识别国家重点实验室
推荐引用方式 GB/T 7714	Zhu, Ye,Jiang, Tianzi,Zhou, Yuan,et al. DISCRIMINATIVE ANALYSIS OF FUNCTIONAL NEAR-INFRARED SPECTROSCOPY SIGNALS FOR DEVELOPMENT OF NEUROIMAGING BIOMARKERS OF ELDERLY DEPRESSION[J]. JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES,2010,3(1):69-74.
APA	Zhu, Ye,Jiang, Tianzi,Zhou, Yuan,&Zhao, Lisha.(2010).DISCRIMINATIVE ANALYSIS OF FUNCTIONAL NEAR-INFRARED SPECTROSCOPY SIGNALS FOR DEVELOPMENT OF NEUROIMAGING BIOMARKERS OF ELDERLY DEPRESSION.JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES,3(1),69-74.
MLA	Zhu, Ye,et al."DISCRIMINATIVE ANALYSIS OF FUNCTIONAL NEAR-INFRARED SPECTROSCOPY SIGNALS FOR DEVELOPMENT OF NEUROIMAGING BIOMARKERS OF ELDERLY DEPRESSION".JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES 3.1(2010):69-74.