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DISCRIMINATIVE ANALYSIS OF FUNCTIONAL NEAR-INFRARED SPECTROSCOPY SIGNALS FOR DEVELOPMENT OF NEUROIMAGING BIOMARKERS OF ELDERLY DEPRESSION
Zhu, Ye1; Jiang, Tianzi1; Zhou, Yuan1; Zhao, Lisha2
2010
发表期刊JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES
卷号3期号:1页码:69-74
文章类型Article
摘要Functional near-infrared spectroscopy (fNIRS) is a neuroimaging technology which is suitable for psychiatric patients. Several fNIRS studies have found abnormal brain activations during cognitive tasks in elderly depression. In this paper, we proposed a discriminative model of multivariate pattern classification based on fNIRS signals to distinguish elderly depressed patients from healthy controls. This model used the brain activation patterns during a verbal fluency task as features of classification. Then Pseudo-Fisher Linear Discriminant Analysis was performed on the feature space to generate discriminative model. Using leave-one-out (LOO) cross-validation, our results showed a correct classification rate of 88%. The discriminative model showed its ability to identify people with elderly depression and suggested that fNIRS may be an efficient clinical tool for diagnosis of depression. This study may provide the first step for the development of neuroimaging biomarkers based on fNIRS in psychiatric disorders.
关键词Functional Near-infrared Spectroscopy (Fnirs) Fisher Linear Discriminant Analysis (Flda) Depression
WOS标题词Science & Technology ; Physical Sciences ; Life Sciences & Biomedicine
收录类别SCI
语种英语
WOS研究方向Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000208647600010
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/9945
专题脑网络组研究中心
作者单位1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100080, Peoples R China
2.Capital Univ Med Sci, Beijing Anding Hosp, Beijing 100088, Peoples R China
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GB/T 7714
Zhu, Ye,Jiang, Tianzi,Zhou, Yuan,et al. DISCRIMINATIVE ANALYSIS OF FUNCTIONAL NEAR-INFRARED SPECTROSCOPY SIGNALS FOR DEVELOPMENT OF NEUROIMAGING BIOMARKERS OF ELDERLY DEPRESSION[J]. JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES,2010,3(1):69-74.
APA Zhu, Ye,Jiang, Tianzi,Zhou, Yuan,&Zhao, Lisha.(2010).DISCRIMINATIVE ANALYSIS OF FUNCTIONAL NEAR-INFRARED SPECTROSCOPY SIGNALS FOR DEVELOPMENT OF NEUROIMAGING BIOMARKERS OF ELDERLY DEPRESSION.JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES,3(1),69-74.
MLA Zhu, Ye,et al."DISCRIMINATIVE ANALYSIS OF FUNCTIONAL NEAR-INFRARED SPECTROSCOPY SIGNALS FOR DEVELOPMENT OF NEUROIMAGING BIOMARKERS OF ELDERLY DEPRESSION".JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES 3.1(2010):69-74.
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