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Recovery of Sensorimotor Function after Experimental Stroke Correlates with Restoration of Resting-State Interhemispheric Functional Connectivity
van Meer, Maurits P. A.1,2; van der Marel, Kajo1; Wang, Kun3; Otte, Willem M.1; el Bouazati, Soufian1; Roeling, Tom A. P.4; Viergever, Max A.1; van der Sprenkel, Jan Willem Berkelbach2; Dijkhuizen, Rick M.1
2010-03-17
发表期刊JOURNAL OF NEUROSCIENCE
卷号30期号:11页码:3964-3972
文章类型Article
摘要Despite the success of functional imaging to map changes in brain activation patterns after stroke, spatiotemporal dynamics of cerebral reorganization in correlation with behavioral recovery remain incompletely characterized. Here, we applied resting-state functional magnetic resonance imaging (rs-fMRI) together with behavioral testing to longitudinally assess functional connectivity within neuronal networks, in relation to changes in associated function after unilateral stroke in rats. Our specific goals were (1) to identify temporal alterations in functional connectivity within the bilateral cortical sensorimotor system and (2) to elucidate the relationship between those alterations and changes in sensorimotor function. Our study revealed considerable loss of functional connectivity between ipsilesional and contralesional primary sensorimotor cortex regions, alongside significant sensorimotor function deficits in the first days after stroke. The interhemispheric functional connectivity restored in the following weeks, but remained significantly reduced up to 10 weeks after stroke in animals with lesions that comprised subcortical and cortical tissue, whereas transcallosal neuroanatomical connections were preserved. Intrahemispheric functional connectivity between primary somatosensory and motor cortex areas was preserved in the lesion border zone and moderately enhanced contralesionally. The temporal pattern of changes in functional connectivity between bilateral primary motor and somatosensory cortices correlated significantly with the evolution of sensorimotor function scores. Our study (1) demonstrates that poststroke loss and recovery of sensorimotor function is associated with acute deterioration and subsequent retrieval of interhemispheric functional connectivity within the sensorimotor system and (2) underscores the potential of rs-fMRI to assess spatiotemporal characteristics of functional brain reorganization that may underlie behavioral recovery after brain injury.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]FOCAL CEREBRAL-ISCHEMIA ; MANGANESE-ENHANCED MRI ; ECHO-PLANAR MRI ; MOTOR CORTEX ; RAT-BRAIN ; SPONTANEOUS FLUCTUATIONS ; ISOFLURANE ANESTHESIA ; GLUCOSE-UTILIZATION ; LONGITUDINAL FMRI ; CORTICAL AREAS
收录类别SCI
语种英语
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000275724800013
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/9971
专题中国科学院分子影像重点实验室
作者单位1.Univ Med Ctr Utrecht, Image Sci Inst, Biomed Magnet Resonance Imaging & Spect Grp, NL-3584 CX Utrecht, Netherlands
2.Univ Med Ctr Utrecht, Dept Neurosurg, Rudolf Magnus Inst Neurosci, NL-3584 CX Utrecht, Netherlands
3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
4.Univ Med Ctr Utrecht, Div Surg Specialties, Dept Anat, NL-3584 CX Utrecht, Netherlands
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van Meer, Maurits P. A.,van der Marel, Kajo,Wang, Kun,et al. Recovery of Sensorimotor Function after Experimental Stroke Correlates with Restoration of Resting-State Interhemispheric Functional Connectivity[J]. JOURNAL OF NEUROSCIENCE,2010,30(11):3964-3972.
APA van Meer, Maurits P. A..,van der Marel, Kajo.,Wang, Kun.,Otte, Willem M..,el Bouazati, Soufian.,...&Dijkhuizen, Rick M..(2010).Recovery of Sensorimotor Function after Experimental Stroke Correlates with Restoration of Resting-State Interhemispheric Functional Connectivity.JOURNAL OF NEUROSCIENCE,30(11),3964-3972.
MLA van Meer, Maurits P. A.,et al."Recovery of Sensorimotor Function after Experimental Stroke Correlates with Restoration of Resting-State Interhemispheric Functional Connectivity".JOURNAL OF NEUROSCIENCE 30.11(2010):3964-3972.
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