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Hippocampal Volume and Asymmetry in Mild Cognitive Impairment and Alzheimer's Disease: Meta-Analyses of MRI Studies
Shi, Feng1; Liu, Bing1; Zhou, Yuan1; Yu, Chunshui2; Jiang, Tianzi1
2009
发表期刊HIPPOCAMPUS
卷号19期号:11页码:1055-1064
文章类型Editorial Material
摘要Numerous studies have reported a smaller hippocampal volume in Alzheimer's disease (AD) patients than in aging controls. However, in mild cognitive impairment (MCI), the results are inconsistent. Moreover, the left-right asymmetry of the hippocampus receives less research attention. In this article, meta-analyses are designed to determine the extent of hippocampal atrophy in MCI and AD, and to evaluate the asymmetry pattern of the hippocampal volume in control, MCI, and AD groups. From 14 studies including 365 MCI patients and 382 controls, significant atrophy is found in both the left [Effect size (ES), 0.92; 95% confidence interval (CI), 0.72-1.11] and right (ES, 0.78, 95% CI, 0.57-0.98) hippocampus, which is lower than that in AD (ES, 1.60, 95% CI, 1.37-1.84, in left; ES, 1.52, 95% Cl, 1.31-1.72, in right). Comparing with aging controls, the average volume reduction weighted by sample size is 12.9% and 11.1% in left and right hippocampus in MCI, and 24.2% and 23.1% in left and right hippocampus in AD, respectively. The findings show a bilateral hippocampal volume loss in MCI and the extent of atrophy is less than that in AD. By comparing the left and right hippocampal volume, a consistent left-less-than-right asymmetry pattern is found, but with different extents in control (ES, 0.39), MCI (ES, 0.56), and AD (ES, 0.30) group. (C) 2009 Wiley-Liss, Inc.
关键词Magnetic Resonance Imaging Hippocampus Volumetric Analysis Asymmetry Meta-analysis
WOS标题词Science & Technology ; Life Sciences & Biomedicine
关键词[WOS]MEDIAL TEMPORAL-LOBE ; CEREBROVASCULAR-DISEASE ; MEMORY PERFORMANCE ; ENTORHINAL CORTEX ; AMYGDALAR VOLUME ; DELAYED RECALL ; SHAPE-ANALYSIS ; ATROPHY ; DEMENTIA ; SCHIZOPHRENIA
收录类别SCI
语种英语
WOS研究方向Neurosciences & Neurology
WOS类目Neurosciences
WOS记录号WOS:000271566100002
引用统计
被引频次:192[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/9976
专题脑网络组研究中心
作者单位1.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100080, Peoples R China
2.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China
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GB/T 7714
Shi, Feng,Liu, Bing,Zhou, Yuan,et al. Hippocampal Volume and Asymmetry in Mild Cognitive Impairment and Alzheimer's Disease: Meta-Analyses of MRI Studies[J]. HIPPOCAMPUS,2009,19(11):1055-1064.
APA Shi, Feng,Liu, Bing,Zhou, Yuan,Yu, Chunshui,&Jiang, Tianzi.(2009).Hippocampal Volume and Asymmetry in Mild Cognitive Impairment and Alzheimer's Disease: Meta-Analyses of MRI Studies.HIPPOCAMPUS,19(11),1055-1064.
MLA Shi, Feng,et al."Hippocampal Volume and Asymmetry in Mild Cognitive Impairment and Alzheimer's Disease: Meta-Analyses of MRI Studies".HIPPOCAMPUS 19.11(2009):1055-1064.
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