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Hippocampal Volume and Asymmetry in Mild Cognitive Impairment and Alzheimer's Disease: Meta-Analyses of MRI Studies
Shi, Feng1; Liu, Bing1; Zhou, Yuan1; Yu, Chunshui2; Jiang, Tianzi1
Source PublicationHIPPOCAMPUS
2009
Volume19Issue:11Pages:1055-1064
SubtypeEditorial Material
AbstractNumerous studies have reported a smaller hippocampal volume in Alzheimer's disease (AD) patients than in aging controls. However, in mild cognitive impairment (MCI), the results are inconsistent. Moreover, the left-right asymmetry of the hippocampus receives less research attention. In this article, meta-analyses are designed to determine the extent of hippocampal atrophy in MCI and AD, and to evaluate the asymmetry pattern of the hippocampal volume in control, MCI, and AD groups. From 14 studies including 365 MCI patients and 382 controls, significant atrophy is found in both the left [Effect size (ES), 0.92; 95% confidence interval (CI), 0.72-1.11] and right (ES, 0.78, 95% CI, 0.57-0.98) hippocampus, which is lower than that in AD (ES, 1.60, 95% CI, 1.37-1.84, in left; ES, 1.52, 95% Cl, 1.31-1.72, in right). Comparing with aging controls, the average volume reduction weighted by sample size is 12.9% and 11.1% in left and right hippocampus in MCI, and 24.2% and 23.1% in left and right hippocampus in AD, respectively. The findings show a bilateral hippocampal volume loss in MCI and the extent of atrophy is less than that in AD. By comparing the left and right hippocampal volume, a consistent left-less-than-right asymmetry pattern is found, but with different extents in control (ES, 0.39), MCI (ES, 0.56), and AD (ES, 0.30) group. (C) 2009 Wiley-Liss, Inc.
KeywordMagnetic Resonance Imaging Hippocampus Volumetric Analysis Asymmetry Meta-analysis
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
WOS KeywordMEDIAL TEMPORAL-LOBE ; CEREBROVASCULAR-DISEASE ; MEMORY PERFORMANCE ; ENTORHINAL CORTEX ; AMYGDALAR VOLUME ; DELAYED RECALL ; SHAPE-ANALYSIS ; ATROPHY ; DEMENTIA ; SCHIZOPHRENIA
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000271566100002
Citation statistics
Cited Times:199[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/9976
Collection脑网络组研究中心
Affiliation1.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100080, Peoples R China
2.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Shi, Feng,Liu, Bing,Zhou, Yuan,et al. Hippocampal Volume and Asymmetry in Mild Cognitive Impairment and Alzheimer's Disease: Meta-Analyses of MRI Studies[J]. HIPPOCAMPUS,2009,19(11):1055-1064.
APA Shi, Feng,Liu, Bing,Zhou, Yuan,Yu, Chunshui,&Jiang, Tianzi.(2009).Hippocampal Volume and Asymmetry in Mild Cognitive Impairment and Alzheimer's Disease: Meta-Analyses of MRI Studies.HIPPOCAMPUS,19(11),1055-1064.
MLA Shi, Feng,et al."Hippocampal Volume and Asymmetry in Mild Cognitive Impairment and Alzheimer's Disease: Meta-Analyses of MRI Studies".HIPPOCAMPUS 19.11(2009):1055-1064.
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