Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
| Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method | |
Liu, Haixiao1,2 ; Yang, Xin1,2; Song, Tianming1; Bao, Chengpeng1; Shi, Liangliang1,2; Hu, Zhenhua1,2; Wang, Kun1,2; Tian, Jie1,2
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| Source Publication | JOURNAL OF BIOMEDICAL OPTICS
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| 2015-08-01 | |
| Volume | 20Issue:8Pages:086007 |
| Subtype | Article |
| Abstract | Cerenkov luminescence tomography (CLT) is a promising tool that enables three-dimensional non-invasive in vivo detection of radiopharmaceuticals. Conventionally, multispectral information and diffusion theory were introduced to achieve whole-body tomographic reconstruction. However, the diffusion theory inevitably causes systematic error in blue bands of the electromagnetic spectrum due to high-tissue absorption, and CL has a blue-weighted broad spectrum. Therefore, it is challenging to improve the accuracy of CLT. The performance of the n-order simplified spherical harmonics approximation (SPn) in different spectra is evaluated, and a multispectral hybrid CLT based on the combination of different SPn models is proposed to handle the Cerenkov photon transport problem in complex media. The in vivo xenograft experiment shows that this approach can effectively improve the quality and accuracy of the reconstructed light source. We believe that the new reconstruction method will advance the development of CLT for more in vivo imaging applications. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE) |
| Keyword | Cerenkov Luminescence Tomography Spherical Harmonics Approximation Multispectral Diffusion Theory |
| WOS Headings | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| DOI | 10.1117/1.JBO.20.8.086007 |
| WOS Keyword | MOUSE MODEL ; LIGHT ; RADIOTRACERS ; PET |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS Subject | Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
| WOS ID | WOS:000362516700018 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ia.ac.cn/handle/173211/10040 |
| Collection | 中国科学院分子影像重点实验室 |
| Corresponding Author | Hu, Zhenhua; Wang, Kun; Tian, Jie |
| Affiliation | 1.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China 2.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China |
| First Author Affilication | Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China |
| Corresponding Author Affilication | Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Liu, Haixiao,Yang, Xin,Song, Tianming,et al. Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method[J]. JOURNAL OF BIOMEDICAL OPTICS,2015,20(8):086007. |
| APA | Liu, Haixiao.,Yang, Xin.,Song, Tianming.,Bao, Chengpeng.,Shi, Liangliang.,...&Tian, Jie.(2015).Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method.JOURNAL OF BIOMEDICAL OPTICS,20(8),086007. |
| MLA | Liu, Haixiao,et al."Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method".JOURNAL OF BIOMEDICAL OPTICS 20.8(2015):086007. |
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| Multispectral hybrid（617KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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