Institutional Repository of Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method | |
Liu, Haixiao1,2; Yang, Xin1,2; Song, Tianming1; Bao, Chengpeng1; Shi, Liangliang1,2; Hu, Zhenhua1,2; Wang, Kun1,2; Tian, Jie1,2 | |
发表期刊 | JOURNAL OF BIOMEDICAL OPTICS |
2015-08-01 | |
卷号 | 20期号:8页码:086007 |
文章类型 | Article |
摘要 | Cerenkov luminescence tomography (CLT) is a promising tool that enables three-dimensional non-invasive in vivo detection of radiopharmaceuticals. Conventionally, multispectral information and diffusion theory were introduced to achieve whole-body tomographic reconstruction. However, the diffusion theory inevitably causes systematic error in blue bands of the electromagnetic spectrum due to high-tissue absorption, and CL has a blue-weighted broad spectrum. Therefore, it is challenging to improve the accuracy of CLT. The performance of the n-order simplified spherical harmonics approximation (SPn) in different spectra is evaluated, and a multispectral hybrid CLT based on the combination of different SPn models is proposed to handle the Cerenkov photon transport problem in complex media. The in vivo xenograft experiment shows that this approach can effectively improve the quality and accuracy of the reconstructed light source. We believe that the new reconstruction method will advance the development of CLT for more in vivo imaging applications. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE) |
关键词 | Cerenkov Luminescence Tomography Spherical Harmonics Approximation Multispectral Diffusion Theory |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
DOI | 10.1117/1.JBO.20.8.086007 |
关键词[WOS] | MOUSE MODEL ; LIGHT ; RADIOTRACERS ; PET |
收录类别 | SCI |
语种 | 英语 |
WOS研究方向 | Biochemistry & Molecular Biology ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
WOS类目 | Biochemical Research Methods ; Optics ; Radiology, Nuclear Medicine & Medical Imaging |
WOS记录号 | WOS:000362516700018 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ia.ac.cn/handle/173211/10040 |
专题 | 中国科学院分子影像重点实验室 |
通讯作者 | Hu, Zhenhua; Wang, Kun; Tian, Jie |
作者单位 | 1.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, Beijing 100190, Peoples R China 2.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China |
第一作者单位 | 中国科学院分子影像重点实验室 |
通讯作者单位 | 中国科学院分子影像重点实验室 |
推荐引用方式 GB/T 7714 | Liu, Haixiao,Yang, Xin,Song, Tianming,et al. Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method[J]. JOURNAL OF BIOMEDICAL OPTICS,2015,20(8):086007. |
APA | Liu, Haixiao.,Yang, Xin.,Song, Tianming.,Bao, Chengpeng.,Shi, Liangliang.,...&Tian, Jie.(2015).Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method.JOURNAL OF BIOMEDICAL OPTICS,20(8),086007. |
MLA | Liu, Haixiao,et al."Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method".JOURNAL OF BIOMEDICAL OPTICS 20.8(2015):086007. |
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