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Structural insights into aberrant cortical morphometry and network organization in psychogenic erectile dysfunction
Zhao, Lu1; Guan, Min2; Zhang, Xiangsheng3; Karama, Sherif1,4; Khundrakpam, Budhachandra1; Wang, Meiyun2; Dong, Minghao5; Qin, Wei5; Tian, Jie5,6; Evans, Alan C.1; Shi, Dapeng2
2015-11-01
发表期刊HUMAN BRAIN MAPPING
卷号36期号:11页码:4469-4482
文章类型Article
摘要Functional neuroimaging studies have revealed abnormal brain dynamics of male sexual arousal (SA) in psychogenic erectile dysfunction (pED). However, the neuroanatomical correlates of pED are still unclear. In this work, we obtained cortical thickness (CTh) measurements from structural magnetic resonance images of 40 pED patients and 39 healthy control subjects. Abnormalities in CTh related to pED were explored using a scale space search based brain morphometric analysis. Organizations of brain structural covariance networks were analyzed as well. Compared with healthy men, pED patients showed significantly decreased CTh in widespread cortical regions, most of which were previously reported to show abnormal dynamics of male SA in pED, such as the medial prefrontal, orbitofrontal, cingulate, inferotemporal, and insular cortices. CTh reductions in these areas were found to be significantly correlated with male sexual functioning degradation. Moreover, pED patients showed decreased interregional CTh correlations from the right lateral orbitofrontal cortex to the right supramarginal gyrus and the left angular cortex, implying disassociations between the cognitive, motivational, and inhibitory networks of male SA in pED. This work provides structural insights on the complex phenomenon of psychogenic sexual dysfunction in men, and suggests a specific vulnerability factor, possibly as an extra organic factor, that may play an important role in pED. Hum Brain Mapp 36:4469-4482, 2015. (c) 2015 Wiley Periodicals, Inc.
关键词Magnetic Resonance Imaging Cortical Thickness Scale Space Search Structural Covariance Network Psychogenic Erectile Dysfunction
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.1002/hbm.22925
关键词[WOS]VISUAL SEXUAL STIMULI ; ANTERIOR CINGULATE CORTEX ; HUMAN CEREBRAL-CORTEX ; BRAIN ACTIVATION ; PENILE ERECTION ; HEALTHY-MEN ; HUMAN MALES ; NEUROPSYCHIATRIC DISORDERS ; INTERNATIONAL INDEX ; DISTINCT COMPONENTS
收录类别SCI
语种英语
项目资助者Canadian Institutes of Health Research(CIHR-MOP 37754) ; Chinese Nature Science Foundation(81271534)
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS类目Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号WOS:000364219500017
引用统计
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/10503
专题中国科学院分子影像重点实验室
通讯作者Tian, Jie
作者单位1.McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ, Canada
2.Henan Prov Peoples Hosp, Dept Radiol, Zhengzhou 450003, Henan, Peoples R China
3.Henan Prov Peoples Hosp, Dept Urol, Zhengzhou 450003, Henan, Peoples R China
4.McGill Univ, Douglas Mental Hlth Univ Inst, Montreal, PQ, Canada
5.Xidian Univ, Sch Life Sci & Technol, Xian, Shaanxi, Peoples R China
6.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
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Zhao, Lu,Guan, Min,Zhang, Xiangsheng,et al. Structural insights into aberrant cortical morphometry and network organization in psychogenic erectile dysfunction[J]. HUMAN BRAIN MAPPING,2015,36(11):4469-4482.
APA Zhao, Lu.,Guan, Min.,Zhang, Xiangsheng.,Karama, Sherif.,Khundrakpam, Budhachandra.,...&Shi, Dapeng.(2015).Structural insights into aberrant cortical morphometry and network organization in psychogenic erectile dysfunction.HUMAN BRAIN MAPPING,36(11),4469-4482.
MLA Zhao, Lu,et al."Structural insights into aberrant cortical morphometry and network organization in psychogenic erectile dysfunction".HUMAN BRAIN MAPPING 36.11(2015):4469-4482.
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