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The Structural Connectivity Pattern of the Default Mode Network and Its Association with Memory and Anxiety
Tao, Yan1,2; Liu, Bing1,2; Zhang, Xiaolong1,2; Li, Jin1,2; Qin, Wen3; Yu, Chunshui3; Jiang, Tianzi1,2,4,5
Source PublicationFRONTIERS IN NEUROANATOMY
2015-11-26
Volume9Issue:Pages:152
SubtypeArticle
AbstractThe default mode network (DMN) is one of the most widely studied resting state functional networks. The structural basis for the DMN is of particular interest and has been studied by several researchers using diffusion tensor imaging (DTI). Most of these previous studies focused on a few regions or white matter tracts of the DMN so that the global structural connectivity pattern and network properties of the DMN remain unclear. Moreover, evidences indicate that the DMN is involved in both memory and emotion, but how the DMN regulates memory and anxiety from the perspective of the whole DMN structural network remains unknown. We used multimodal neuroimaging methods to investigate the structural connectivity pattern of the DMN and the association of its network properties with memory and anxiety in 205 young healthy subjects with age ranging from 18 to 29 years old. The Group ICA method was used to extract the DMN component from functional magnetic resonance imaging (fMRI) data and a probabilistic fiber tractography technique based on DTI data was applied to construct the global structural connectivity pattern of the DMN. Then we used the graph theory method to analyze the DMN structural network and found that memory quotient (MQ) score was significantly positively correlated with the global and local efficiency of the DMN whereas anxiety was found to be negatively correlated with the efficiency. The strong structural connectivity between multiple brain regions within DMN may reflect that the DMN has certain structural basis. Meanwhile, the results we found that the network efficiency of the DMN were related to memory and anxiety measures, indicated that the DMN may play a role in the memory and anxiety.
KeywordDti Default Mode Network Memory Anxiety Structural Network
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.3389/fnana.2015.00152
WOS KeywordMEDIAL PREFRONTAL CORTEX ; STATE FUNCTIONAL CONNECTIVITY ; POSTERIOR CINGULATE CORTEX ; MILD COGNITIVE IMPAIRMENT ; RESTING-STATE ; BIPOLAR DISORDER ; ALZHEIMERS-DISEASE ; VENTRAL HIPPOCAMPUS ; BRAIN-FUNCTION ; SCHIZOPHRENIA
Indexed BySCI
Language英语
Funding OrganizationNational Key Basic Research and Development Program (973)(2011CB707800) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(91232718 ; Youth Innovation Promotion Association, Chinese Academy of Science ; 91132301)
WOS Research AreaAnatomy & Morphology ; Neurosciences & Neurology
WOS SubjectAnatomy & Morphology ; Neurosciences
WOS IDWOS:000365850800001
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ia.ac.cn/handle/173211/10532
Collection脑网络组研究中心
Corresponding AuthorLiu, Bing
Affiliation1.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China
2.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing, Peoples R China
3.Tianjin Med Univ, Dept Radiol, Gen Hosp, Tianjin, Peoples R China
4.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
5.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab Neuroinformat, Chengdu 610054, Peoples R China
Recommended Citation
GB/T 7714
Tao, Yan,Liu, Bing,Zhang, Xiaolong,et al. The Structural Connectivity Pattern of the Default Mode Network and Its Association with Memory and Anxiety[J]. FRONTIERS IN NEUROANATOMY,2015,9(无):152.
APA Tao, Yan.,Liu, Bing.,Zhang, Xiaolong.,Li, Jin.,Qin, Wen.,...&Jiang, Tianzi.(2015).The Structural Connectivity Pattern of the Default Mode Network and Its Association with Memory and Anxiety.FRONTIERS IN NEUROANATOMY,9(无),152.
MLA Tao, Yan,et al."The Structural Connectivity Pattern of the Default Mode Network and Its Association with Memory and Anxiety".FRONTIERS IN NEUROANATOMY 9.无(2015):152.
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