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The Structural Connectivity Pattern of the Default Mode Network and Its Association with Memory and Anxiety
Tao, Yan1,2; Liu, Bing1,2; Zhang, Xiaolong1,2; Li, Jin1,2; Qin, Wen3; Yu, Chunshui3; Jiang, Tianzi1,2,4,5
2015-11-26
发表期刊FRONTIERS IN NEUROANATOMY
卷号9期号:页码:152
文章类型Article
摘要The default mode network (DMN) is one of the most widely studied resting state functional networks. The structural basis for the DMN is of particular interest and has been studied by several researchers using diffusion tensor imaging (DTI). Most of these previous studies focused on a few regions or white matter tracts of the DMN so that the global structural connectivity pattern and network properties of the DMN remain unclear. Moreover, evidences indicate that the DMN is involved in both memory and emotion, but how the DMN regulates memory and anxiety from the perspective of the whole DMN structural network remains unknown. We used multimodal neuroimaging methods to investigate the structural connectivity pattern of the DMN and the association of its network properties with memory and anxiety in 205 young healthy subjects with age ranging from 18 to 29 years old. The Group ICA method was used to extract the DMN component from functional magnetic resonance imaging (fMRI) data and a probabilistic fiber tractography technique based on DTI data was applied to construct the global structural connectivity pattern of the DMN. Then we used the graph theory method to analyze the DMN structural network and found that memory quotient (MQ) score was significantly positively correlated with the global and local efficiency of the DMN whereas anxiety was found to be negatively correlated with the efficiency. The strong structural connectivity between multiple brain regions within DMN may reflect that the DMN has certain structural basis. Meanwhile, the results we found that the network efficiency of the DMN were related to memory and anxiety measures, indicated that the DMN may play a role in the memory and anxiety.
关键词Dti Default Mode Network Memory Anxiety Structural Network
WOS标题词Science & Technology ; Life Sciences & Biomedicine
DOI10.3389/fnana.2015.00152
关键词[WOS]MEDIAL PREFRONTAL CORTEX ; STATE FUNCTIONAL CONNECTIVITY ; POSTERIOR CINGULATE CORTEX ; MILD COGNITIVE IMPAIRMENT ; RESTING-STATE ; BIPOLAR DISORDER ; ALZHEIMERS-DISEASE ; VENTRAL HIPPOCAMPUS ; BRAIN-FUNCTION ; SCHIZOPHRENIA
收录类别SCI
语种英语
项目资助者National Key Basic Research and Development Program (973)(2011CB707800) ; Strategic Priority Research Program of the Chinese Academy of Sciences(XDB02030300) ; Natural Science Foundation of China(91232718 ; Youth Innovation Promotion Association, Chinese Academy of Science ; 91132301)
WOS研究方向Anatomy & Morphology ; Neurosciences & Neurology
WOS类目Anatomy & Morphology ; Neurosciences
WOS记录号WOS:000365850800001
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.ia.ac.cn/handle/173211/10532
专题脑网络组研究中心
通讯作者Liu, Bing
作者单位1.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China
2.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing, Peoples R China
3.Tianjin Med Univ, Dept Radiol, Gen Hosp, Tianjin, Peoples R China
4.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
5.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab Neuroinformat, Chengdu 610054, Peoples R China
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Tao, Yan,Liu, Bing,Zhang, Xiaolong,et al. The Structural Connectivity Pattern of the Default Mode Network and Its Association with Memory and Anxiety[J]. FRONTIERS IN NEUROANATOMY,2015,9(无):152.
APA Tao, Yan.,Liu, Bing.,Zhang, Xiaolong.,Li, Jin.,Qin, Wen.,...&Jiang, Tianzi.(2015).The Structural Connectivity Pattern of the Default Mode Network and Its Association with Memory and Anxiety.FRONTIERS IN NEUROANATOMY,9(无),152.
MLA Tao, Yan,et al."The Structural Connectivity Pattern of the Default Mode Network and Its Association with Memory and Anxiety".FRONTIERS IN NEUROANATOMY 9.无(2015):152.
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